TY - JOUR
T1 - Magnetic Resonance Enterography and Histology in Patients With Fibrostenotic Crohn's Disease
T2 - A Multicenter Study
AU - Coimbra, Alexandre
AU - Rimola, Jordi
AU - Cuatrecasas, Miriam
AU - de Hertogh, Gert
AU - van Assche, Gert
AU - Vanslembrouck, Ragna
AU - Glerup, Henning
AU - Nielsen, Agnete Hedemann
AU - Hagemann-Madsen, Rikke
AU - Bouhnik, Yoram
AU - Zappa, Magaly
AU - Cazals-Hatem, Dominique
AU - D'Haens, Geert
AU - Stoker, Jaap
AU - Meijer, Sybren
AU - Rogler, Gerhard
AU - Boss, Andreas
AU - Weber, Achim
AU - Zhao, Rui
AU - Keir, Mary E.
AU - Scherl, Alexis
AU - de Crespigny, Alex
AU - Lu, Timothy T.
AU - Panés, Julián
N1 - Publisher Copyright: © 2022 Lippincott Williams and Wilkins. All rights reserved.
PY - 2022/7/1
Y1 - 2022/7/1
N2 - Introduction:Magnetic resonance enterography (MRE) is useful for detecting bowel strictures, while a number of imaging biomarkers may reflect severity of fibrosis burden in Crohn's disease (CD). This study aimed to verify association of MRE metrics with histologic fibrosis independent of inflammation.Methods:This prospective European multicenter study performed MRE imaging on 60 CD patients with bowel strictures prior to surgical resection. Locations of 61 histological samples were annotated on MRE examinations, followed by central readings using the Chiorean score and measurement of delayed gain of enhancement (DGE), magnetization transfer ratio (MTR), T2-weighted magnetic resonance imaging sequences (T2R), apparent diffusion coefficient (ADC), and the magnetic resonance index of activity (MaRIA). Correlations of histology and MRE metrics were assessed. Least Absolute Shrinkage and Selection Operator (LASSO) and receiver operator characteristic (ROC) curve analyses were used to select composite MRE scores predictive of histology and to estimate their predictive value.Results:ADC and MaRIA correlated with fibrosis (R=-0.71, P<0.0001, and 0.59, P<0.001) and more moderately with inflammation (R=-0.35, P<0.01, and R=0.53, P<0.001). Lower or no correlations of fibrosis or inflammation were found with DGE, MTR, or T2R. LASSO and ROC identified a composite score of MaRIA, ADC, and DGE as a very good predictor of histologic fibrosis (ROCAUC=0.910). MaRIA alone was the best predictor of histologic inflammation with excellent performance in identifying active histologic inflammation (ROCAUC=0.966).Discussion:MRE-based scores for histologic fibrosis and inflammation may assist in the characterization of CD stenosis and enable development of fibrosis-targeted therapies and clinical treatment of stenotic patients.
AB - Introduction:Magnetic resonance enterography (MRE) is useful for detecting bowel strictures, while a number of imaging biomarkers may reflect severity of fibrosis burden in Crohn's disease (CD). This study aimed to verify association of MRE metrics with histologic fibrosis independent of inflammation.Methods:This prospective European multicenter study performed MRE imaging on 60 CD patients with bowel strictures prior to surgical resection. Locations of 61 histological samples were annotated on MRE examinations, followed by central readings using the Chiorean score and measurement of delayed gain of enhancement (DGE), magnetization transfer ratio (MTR), T2-weighted magnetic resonance imaging sequences (T2R), apparent diffusion coefficient (ADC), and the magnetic resonance index of activity (MaRIA). Correlations of histology and MRE metrics were assessed. Least Absolute Shrinkage and Selection Operator (LASSO) and receiver operator characteristic (ROC) curve analyses were used to select composite MRE scores predictive of histology and to estimate their predictive value.Results:ADC and MaRIA correlated with fibrosis (R=-0.71, P<0.0001, and 0.59, P<0.001) and more moderately with inflammation (R=-0.35, P<0.01, and R=0.53, P<0.001). Lower or no correlations of fibrosis or inflammation were found with DGE, MTR, or T2R. LASSO and ROC identified a composite score of MaRIA, ADC, and DGE as a very good predictor of histologic fibrosis (ROCAUC=0.910). MaRIA alone was the best predictor of histologic inflammation with excellent performance in identifying active histologic inflammation (ROCAUC=0.966).Discussion:MRE-based scores for histologic fibrosis and inflammation may assist in the characterization of CD stenosis and enable development of fibrosis-targeted therapies and clinical treatment of stenotic patients.
KW - Crohn's Disease
KW - fibrosis
KW - magnetic resonance
KW - strictures
UR - http://www.scopus.com/inward/record.url?scp=85135218010&partnerID=8YFLogxK
U2 - https://doi.org/10.14309/ctg.0000000000000505
DO - https://doi.org/10.14309/ctg.0000000000000505
M3 - Article
C2 - 35905415
SN - 2155-384X
VL - 13
SP - e00505
JO - Clinical and translational gastroenterology
JF - Clinical and translational gastroenterology
IS - 7
ER -