TY - JOUR
T1 - Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: A comparative study
AU - Dirix, Marc
AU - van Becelaere, Tine
AU - Berkenbosch, Lizanne
AU - van Baren, Robertine
AU - Wijnen, Rene M.
AU - Wijnen, Marc H.
AU - van der Zee, David C.
AU - Heij, Hugo A.
AU - Derikx, Joep P. M.
AU - van Heurn, L. W. Ernest
PY - 2015
Y1 - 2015
N2 - Background/purpose: The risk of malignant transformation of sacrococcygeal teratoma (SCT) and of presacral teratoma in Currarino syndrome (CS) may differ despite the similar position and appearance. Methods: Malignant transformation and teratoma recurrence were assessed in a national retrospective comparative analysis of 205 SCT and 16 CS patients treated in one of the six pediatric surgical centers in the Netherlands between January 1981 and December 2010. Results: The malignancy free survival of patients with SCT was lower than for patients with a presacral teratoma associated with CS (80% and 58% after one and two years in SCT versus 100% after two years in CS, p = 0.017) Conclusions: In SCT, malignancy and recurrence risk are high. Therefore, early and complete resection is mandatory. Our data show that the risk of malignant transformation of a presacral teratoma in CS is small. (C) 2015 Elsevier Inc. All rights reserved
AB - Background/purpose: The risk of malignant transformation of sacrococcygeal teratoma (SCT) and of presacral teratoma in Currarino syndrome (CS) may differ despite the similar position and appearance. Methods: Malignant transformation and teratoma recurrence were assessed in a national retrospective comparative analysis of 205 SCT and 16 CS patients treated in one of the six pediatric surgical centers in the Netherlands between January 1981 and December 2010. Results: The malignancy free survival of patients with SCT was lower than for patients with a presacral teratoma associated with CS (80% and 58% after one and two years in SCT versus 100% after two years in CS, p = 0.017) Conclusions: In SCT, malignancy and recurrence risk are high. Therefore, early and complete resection is mandatory. Our data show that the risk of malignant transformation of a presacral teratoma in CS is small. (C) 2015 Elsevier Inc. All rights reserved
U2 - https://doi.org/10.1016/j.jpedsurg.2014.07.014
DO - https://doi.org/10.1016/j.jpedsurg.2014.07.014
M3 - Article
C2 - 25746708
SN - 0022-3468
VL - 50
SP - 462
EP - 464
JO - Journal of Pediatric Surgery
JF - Journal of Pediatric Surgery
IS - 3
ER -