Management of granulomatous lobular mastitis: an international multidisciplinary consensus (2021 edition)

Qian Qian Yuan, Shu Xuan Xiao, Omar Farouk, Yu Tang Du, Fereshte Sheybani, Qing Ting Tan, Sami Akbulut, Kenan Cetin, Afsaneh Alikhassi, Rami Jalal Yaghan, Irmak Durur-Subasi, Fatih Altintoprak, Tae Ik Eom, Fatih Alper, Mustafa Hasbahceci, David Martínez-Ramos, Pelin Seher Oztekin, Ava Kwong, Cedric W. Pluguez-Turull, Kirstyn E. BrownsonShirish Chandanwale, Mehran Habibi, Liu Yi Lan, Rui Zhou, Xian Tao Zeng, Jiao Bai, Jun Wen Bai, Qiong Rong Chen, Xing Chen, Xiao Ming Zha, Wen Jie Dai, Zhi Jun Dai, Qin Yu Feng, Qing Jun Gao, Run Fang Gao, Bao San Han, Jin Xuan Hou, Wei Hou, Hai Ying Liao, Hong Luo, Zheng Ren Liu, Jing Hua Lu, Bin Luo, Xiao Peng Ma, Jun Qian, Jian Yong Qin, Wei Wei, Gang Wei, Li Ying Xu, Hui Chao Xue, Hua Wei Yang, Wei Ge Yang, Chao Jie Zhang, Fan Zhang, Guan Xin Zhang, Shao Kun Zhang, Shu Qun Zhang, Ye Qiang Zhang, Yue Peng Zhang, Sheng Chu Zhang, Dai Wei Zhao, Xiang Min Zheng, Le Wei Zheng, Gao Ran Xu, Wen Bo Zhou, Gao Song Wu

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3 Citations (Scopus)

Abstract

Granulomatous lobular mastitis (GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care for patients with inflammatory disorders of the breast. This consensus is summarized to establish evidence-based recommendations for the management of GLM. Literature was reviewed using PubMed from January 1, 1971 to July 31, 2020. Sixty-six international experienced multidisciplinary experts from 11 countries or regions were invited to review the evidence. Levels of evidence were determined using the American College of Physicians grading system, and recommendations were discussed until consensus. Experts discussed and concluded 30 recommendations on historical definitions, etiology and predisposing factors, diagnosis criteria, treatment, clinical stages, relapse and recurrence of GLM. GLM was recommended as a widely accepted definition. In addition, this consensus introduced a new clinical stages and management algorithm for GLM to provide individual treatment strategies. In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and pathology. The approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidence-based consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM.

Original languageEnglish
Article number20
JournalMilitary Medical Research
Volume9
Issue number1
DOIs
Publication statusPublished - Dec 2022

Keywords

  • Diagnosis
  • Granulomatous lobular mastitis
  • Granulomatous mastitis
  • Idiopathic granulomatous mastitis
  • Treatment

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