TY - JOUR
T1 - Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium
AU - ENIGMA OCD Working Group
AU - Kong, Xiang-Zhen
AU - Boedhoe, Premika S. W.
AU - Abe, Yoshinari
AU - Alonso, Pino
AU - Ameis, Stephanie H.
AU - Arnold, Paul D.
AU - Assogna, Francesca
AU - Baker, Justin T.
AU - Batistuzzo, Marcelo C.
AU - Benedetti, Francesco
AU - Beucke, Jan C.
AU - Bollettini, Irene
AU - Bose, Anushree
AU - Brem, Silvia
AU - Brennan, Brian P.
AU - Buitelaar, Jan
AU - Calvo, Rosa
AU - Cheng, Yuqi
AU - Cho, Kang Ik K.
AU - Dallaspezia, Sara
AU - Denys, Damiaan
AU - Ely, Benjamin A.
AU - Feusner, Jamie
AU - Fitzgerald, Kate D.
AU - Fouche, Jean-Paul
AU - Fridgeirsson, Egill A.
AU - Glahn, David C.
AU - Gruner, Patricia
AU - Gürsel, Deniz A.
AU - Hauser, Tobias U.
AU - Hirano, Yoshiyuki
AU - Hoexter, Marcelo Q.
AU - Hu, Hao
AU - Huyser, Chaim
AU - James, Anthony
AU - Jaspers-Fayer, Fern
AU - Kathmann, Norbert
AU - Kaufmann, Christian
AU - Koch, Kathrin
AU - Kuno, Masaru
AU - Kvale, Gerd
AU - Kwon, Jun Soo
AU - Schmaal, Lianne
AU - de Vries, Froukje E.
AU - de Wit, Stella J.
AU - Figee, Martijn
AU - Thorsen, Anders Lillevik
AU - van der Werf, Ysbrand D.
AU - Veltman, Dick J.
AU - van den Heuvel, Odile A.
AU - Lazaro, Luisa
AU - Liu, Yanni
AU - Lochner, Christine
AU - Marques, Paulo
AU - Marsh, Rachel
AU - van Wingen, Guido A.
PY - 2020/6/15
Y1 - 2020/6/15
N2 - Background: Lateralized dysfunction has been suggested in obsessive-compulsive disorder (OCD). However, it is currently unclear whether OCD is characterized by abnormal patterns of brain structural asymmetry. Here we carried out what is by far the largest study of brain structural asymmetry in OCD. Methods: We studied a collection of 16 pediatric datasets (501 patients with OCD and 439 healthy control subjects), as well as 30 adult datasets (1777 patients and 1654 control subjects) from the OCD Working Group within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium. Asymmetries of the volumes of subcortical structures, and of measures of regional cortical thickness and surface areas, were assessed based on T1-weighted magnetic resonance imaging scans, using harmonized image analysis and quality control protocols. We investigated possible alterations of brain asymmetry in patients with OCD. We also explored potential associations of asymmetry with specific aspects of the disorder and medication status. Results: In the pediatric datasets, the largest case-control differences were observed for volume asymmetry of the thalamus (more leftward; Cohen's d = 0.19) and the pallidum (less leftward; d = −0.21). Additional analyses suggested putative links between these asymmetry patterns and medication status, OCD severity, or anxiety and depression comorbidities. No significant case-control differences were found in the adult datasets. Conclusions: The results suggest subtle changes of the average asymmetry of subcortical structures in pediatric OCD, which are not detectable in adults with the disorder. These findings may reflect altered neurodevelopmental processes in OCD.
AB - Background: Lateralized dysfunction has been suggested in obsessive-compulsive disorder (OCD). However, it is currently unclear whether OCD is characterized by abnormal patterns of brain structural asymmetry. Here we carried out what is by far the largest study of brain structural asymmetry in OCD. Methods: We studied a collection of 16 pediatric datasets (501 patients with OCD and 439 healthy control subjects), as well as 30 adult datasets (1777 patients and 1654 control subjects) from the OCD Working Group within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium. Asymmetries of the volumes of subcortical structures, and of measures of regional cortical thickness and surface areas, were assessed based on T1-weighted magnetic resonance imaging scans, using harmonized image analysis and quality control protocols. We investigated possible alterations of brain asymmetry in patients with OCD. We also explored potential associations of asymmetry with specific aspects of the disorder and medication status. Results: In the pediatric datasets, the largest case-control differences were observed for volume asymmetry of the thalamus (more leftward; Cohen's d = 0.19) and the pallidum (less leftward; d = −0.21). Additional analyses suggested putative links between these asymmetry patterns and medication status, OCD severity, or anxiety and depression comorbidities. No significant case-control differences were found in the adult datasets. Conclusions: The results suggest subtle changes of the average asymmetry of subcortical structures in pediatric OCD, which are not detectable in adults with the disorder. These findings may reflect altered neurodevelopmental processes in OCD.
UR - http://www.scopus.com/inward/record.url?scp=85066780035&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.biopsych.2019.04.022
DO - https://doi.org/10.1016/j.biopsych.2019.04.022
M3 - Article
C2 - 31178097
SN - 0006-3223
VL - 87
SP - 1022
EP - 1034
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 12
ER -