TY - JOUR
T1 - Mapping of T1-Values and Gadolinium-Concentrations in MRI as Indicator of Disease Activity in Luminal Crohn's Disease: A Feasibility Study
AU - Horsthuis, Karin
AU - Nederveen, Aart J.
AU - de Feiter, Marijn-Willem
AU - Lavini, Cristina
AU - Stokkers, Pieter C. F.
AU - Stoker, Jaap
PY - 2009
Y1 - 2009
N2 - Purpose: To determine the feasibility of T1-mapping and calculation of Gadolinium-values in luminal Crohn's Disease (CD). Materials and Methods: Nine patients with active CD were included. For each patient disease activity was determined, based on endoscopic and histopathological results. The Crohn's Disease Endoscopic Index of Severity (CDEIS), the Harvey-Bradshaw index (HBI) and C-reactive protein (CRP) were also determined as reference standards. T1-measurements were performed before and after intravenous administration of Gadodiamide in 14 slices in a single breath-hold using the Look-Locker (LL) sequence in combination with a segmented three-dimensional Turbo Field Echo sequence. A Region of Interest (ROI) was drawn around inflamed bowel loops and the mean Gadolinium-concentration within the ROI was calculated. Gadolinium-concentrations were compared between patients with mild and marked disease, as determined by the reference standards. Results: Mean Gadolinium-concentrations were higher in bowel loops of patients with more active disease, as defined by endoscopic and histopathological examination, CRP, and HBI. Conclusion: By using a breath-hold LL sequence in the bowel quantitative assessment of contrast agent concentration is possible, thus permitting objective evaluation of physiological changes in actively inflamed tissue in an area that suffers from motion problems
AB - Purpose: To determine the feasibility of T1-mapping and calculation of Gadolinium-values in luminal Crohn's Disease (CD). Materials and Methods: Nine patients with active CD were included. For each patient disease activity was determined, based on endoscopic and histopathological results. The Crohn's Disease Endoscopic Index of Severity (CDEIS), the Harvey-Bradshaw index (HBI) and C-reactive protein (CRP) were also determined as reference standards. T1-measurements were performed before and after intravenous administration of Gadodiamide in 14 slices in a single breath-hold using the Look-Locker (LL) sequence in combination with a segmented three-dimensional Turbo Field Echo sequence. A Region of Interest (ROI) was drawn around inflamed bowel loops and the mean Gadolinium-concentration within the ROI was calculated. Gadolinium-concentrations were compared between patients with mild and marked disease, as determined by the reference standards. Results: Mean Gadolinium-concentrations were higher in bowel loops of patients with more active disease, as defined by endoscopic and histopathological examination, CRP, and HBI. Conclusion: By using a breath-hold LL sequence in the bowel quantitative assessment of contrast agent concentration is possible, thus permitting objective evaluation of physiological changes in actively inflamed tissue in an area that suffers from motion problems
U2 - https://doi.org/10.1002/jmri.21535
DO - https://doi.org/10.1002/jmri.21535
M3 - Article
C2 - 19161209
SN - 1053-1807
VL - 29
SP - 488
EP - 493
JO - Journal of magnetic resonance imaging
JF - Journal of magnetic resonance imaging
IS - 2
ER -