Measurement of biofilm growth and local hydrodynamics using optical coherence tomography

Nicolas Weiss, Khalid El Tayeb El Obied, Jeroen Kalkman, Rob G. H. Lammertink, Ton G. van Leeuwen

Research output: Contribution to JournalArticleAcademicpeer-review

13 Citations (Scopus)


We report on localized and simultaneous measurement of biofilm growth and local hydrodynamics in a microfluidic channel using optical coherence tomography. We measure independently with high spatio-temporal resolution the longitudinal flow velocity component parallel to the imaging beam and the transverse flow velocity component perpendicular to the imaging beam. Based on the measured velocities we calculate the shear-rates in the flow channel. We show the relation between the measured biofilm structure and flow velocities as biofilm growth progresses over the course of 48 hours. (C) 2016 Optical Society of America
Original languageEnglish
Pages (from-to)3508-3518
JournalBiomedical Optics Express
Issue number9
Publication statusPublished - 2016

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