TY - JOUR
T1 - Measurement tools for assessment of older age bipolar disorder: A systematic review of the recent global literature
AU - Rej, Soham
AU - Quayle, William
AU - Forester, Brent P.
AU - Dols, Annemiek
AU - Gatchel, Jennifer
AU - Chen, Peijun
AU - Gough, Sarah
AU - Fox, Rebecca
AU - Sajatovic, Martha
AU - Strejilevich, Sergio A.
AU - Eyler, Lisa T.
PY - 2018
Y1 - 2018
N2 - Objectives: More than 50% of people with bipolar disorder will be age 60 years or older by 2030. There is a need for more data to guide assessment and treatment in older age bipolar disorder (OABD); however, interpretation of findings from small, single-site studies may not be generalizable and there are few large trials. As a step in the direction of coordinated large-scale OABD data collection, it is critical to identify which measurements are currently used and identify potential gaps in domains typically assessed. Methods: An international group of OABD experts performed a systematic literature review to identify studies examining OABD in the past 6 years. Relevant articles were assessed to categorize the types of clinical, cognitive, biomarker, and neuroimaging OABD tools routinely used in OABD studies. Results: A total of 53 papers were identified, with a broad range of assessments. Most studies evaluated demographic and clinical domains, with fewer studies assessing cognition. There are relatively few biomarker and neuroimaging data, and data collection methods were less comprehensively covered. Conclusion: Assessment tools used in the recent OABD literature may help to identify both a minimum and a comprehensive dataset that should be evaluated in OABD. Our review also highlights gaps where key clinical outcomes have not been routinely assessed. Biomarker and neuroimaging assessment could be further developed and standardized. Clinical data could be combined with neuroimaging, genetic, and other biomarkers in large-scale coordinated data collection to further improve our understanding of OABD phenomenology and biology, thereby contributing to research that advances care.
AB - Objectives: More than 50% of people with bipolar disorder will be age 60 years or older by 2030. There is a need for more data to guide assessment and treatment in older age bipolar disorder (OABD); however, interpretation of findings from small, single-site studies may not be generalizable and there are few large trials. As a step in the direction of coordinated large-scale OABD data collection, it is critical to identify which measurements are currently used and identify potential gaps in domains typically assessed. Methods: An international group of OABD experts performed a systematic literature review to identify studies examining OABD in the past 6 years. Relevant articles were assessed to categorize the types of clinical, cognitive, biomarker, and neuroimaging OABD tools routinely used in OABD studies. Results: A total of 53 papers were identified, with a broad range of assessments. Most studies evaluated demographic and clinical domains, with fewer studies assessing cognition. There are relatively few biomarker and neuroimaging data, and data collection methods were less comprehensively covered. Conclusion: Assessment tools used in the recent OABD literature may help to identify both a minimum and a comprehensive dataset that should be evaluated in OABD. Our review also highlights gaps where key clinical outcomes have not been routinely assessed. Biomarker and neuroimaging assessment could be further developed and standardized. Clinical data could be combined with neuroimaging, genetic, and other biomarkers in large-scale coordinated data collection to further improve our understanding of OABD phenomenology and biology, thereby contributing to research that advances care.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85032946934&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29108106
U2 - https://doi.org/10.1111/bdi.12566
DO - https://doi.org/10.1111/bdi.12566
M3 - Article
C2 - 29108106
SN - 1398-5647
VL - 20
SP - 359
EP - 369
JO - Bipolar disorders
JF - Bipolar disorders
IS - 4
ER -