Mechanisms linking depression to cardiovascular disease: What do epidemiological studies tell us?

Brenda W.J.H. Penninx

doi:https://doi.org/10.1007/978-3-319-32480-7_4

Mechanisms linking depression to cardiovascular disease: What do epidemiological studies tell us?

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Abstract

The burden of disease for depression goes beyond functioning and quality of life and extends to somatic health. Depression has shown to subsequently increase the risk of cardiovascular morbidity and mortality. These somatic consequences can be partly explained by mediating mechanisms such as unhealthy lifestyle (smoking, excessive alcohol use, physical inactivity, unhealthy diet) or unfavorable pathophysiological disturbances (metabolic, immuno-inflammatory, autonomic, and HPA-axis dysregulations). This chapter presents epidemiological evidence for the existence of these plausible underlying mechanisms that link depression to cardiovascular disease. However, alternative explanations for an increased cardiovascular risk in depressed persons are also discussed, namely, the confounding hypothesis, iatrogenic effects, or noncausal "third factors."

Original language	English
Title of host publication	Cardiovascular Diseases and Depression
Subtitle of host publication	Treatment and Prevention in Psychocardiology
Editors	B. Baune, P. Tully
Place of Publication	Cham
Publisher	Springer International Publishing Switzerland
Pages	37-52
Number of pages	16
ISBN (Electronic)	9783319324807
ISBN (Print)	9783319324784
DOIs	https://doi.org/10.1007/978-3-319-32480-7_4
Publication status	Published - 1 Jan 2016

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Mechanisms linking depression to cardiovascular disease: What do epidemiological studies tell us? / Penninx, Brenda W.J.H.
Cardiovascular Diseases and Depression: Treatment and Prevention in Psychocardiology. ed. / B. Baune; P. Tully. Cham: Springer International Publishing Switzerland, 2016. p. 37-52.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

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Mechanisms linking depression to cardiovascular disease: What do epidemiological studies tell us?

Abstract

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