Mechanisms of bone resorption

Vincent Everts, Ineke D.C. Jansen, Teun J. de Vries

Research output: Contribution to JournalArticleAcademicpeer-review


Resorption of mineralized tissues like bone is accomplished by a unique cell type: the osteoclast. This multinucleated cell has the capacity to dissolve the mineral by lowering the pH. Subsequently, the release of certain proteolytic enzymes, in particular cathepsin K, results in the digestion of the organic matrix mainly consisting of collagen. In this short review we will describe the unique features of the osteoclast making it possible for the cell to resorb mineralized tissues.

Original languageEnglish
Article number116499
Number of pages7
Early online date21 Jul 2022
Publication statusE-pub ahead of print - 21 Jul 2022


  • Demineralization
  • Osteoclast
  • Osteoclast heterogeneity
  • Protein degradation
  • Resorption

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