Mechanisms of bone resorption

Vincent Everts; Ineke D.C. Jansen; Teun J. de Vries

doi:https://doi.org/10.1016/j.bone.2022.116499

Mechanisms of bone resorption

Vincent Everts, Ineke D.C. Jansen, Teun J. de Vries

Internal Medicine (VUmc)

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Resorption of mineralized tissues like bone is accomplished by a unique cell type: the osteoclast. This multinucleated cell has the capacity to dissolve the mineral by lowering the pH. Subsequently, the release of certain proteolytic enzymes, in particular cathepsin K, results in the digestion of the organic matrix mainly consisting of collagen. In this short review we will describe the unique features of the osteoclast making it possible for the cell to resorb mineralized tissues.

Original language	English
Article number	116499
Number of pages	7
Journal	Bone
Early online date	21 Jul 2022
DOIs	https://doi.org/10.1016/j.bone.2022.116499
Publication status	E-pub ahead of print - 21 Jul 2022

Keywords

Demineralization
Osteoclast
Osteoclast heterogeneity
Protein degradation
Resorption

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https://doi.org/10.1016/j.bone.2022.116499

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abstract = "Resorption of mineralized tissues like bone is accomplished by a unique cell type: the osteoclast. This multinucleated cell has the capacity to dissolve the mineral by lowering the pH. Subsequently, the release of certain proteolytic enzymes, in particular cathepsin K, results in the digestion of the organic matrix mainly consisting of collagen. In this short review we will describe the unique features of the osteoclast making it possible for the cell to resorb mineralized tissues.",

keywords = "Demineralization, Osteoclast, Osteoclast heterogeneity, Protein degradation, Resorption",

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AU - de Vries, Teun J.

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N2 - Resorption of mineralized tissues like bone is accomplished by a unique cell type: the osteoclast. This multinucleated cell has the capacity to dissolve the mineral by lowering the pH. Subsequently, the release of certain proteolytic enzymes, in particular cathepsin K, results in the digestion of the organic matrix mainly consisting of collagen. In this short review we will describe the unique features of the osteoclast making it possible for the cell to resorb mineralized tissues.

AB - Resorption of mineralized tissues like bone is accomplished by a unique cell type: the osteoclast. This multinucleated cell has the capacity to dissolve the mineral by lowering the pH. Subsequently, the release of certain proteolytic enzymes, in particular cathepsin K, results in the digestion of the organic matrix mainly consisting of collagen. In this short review we will describe the unique features of the osteoclast making it possible for the cell to resorb mineralized tissues.

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KW - Protein degradation

KW - Resorption

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Mechanisms of bone resorption

Abstract

Keywords

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