@article{cd3100efd26a4b4fa6e7a71d0c44b8a2,
title = "Mediastinal large B cell lymphoma and surrounding gray areas: a report of the lymphoma workshop of the 20th meeting of the European Association for Haematopathology",
abstract = "Session 3 of the 2021 European Association for Haematopathology/Society for Hematopathology Workshop focused on mediastinal large B cell lymphomas and surrounding gray areas. One half of the session was dedicated to primary mediastinal large B cell lymphoma (PMBL) and included cases with classic clinicopathologic features, as well as cases with either morphologic or immunophenotypic variation, and PMBL-like cases with primary extramediastinal disease. The role of additional immunophenotyping and/or molecular testing to aid in the diagnosis of PMBL was discussed. The second half of the session focused on mediastinal and non-mediastinal gray zone lymphomas (GZL) with features intermediate between diffuse large B cell lymphoma (DLBCL) and classic Hodgkin lymphoma (CHL). Several cases illustrating the current challenges in separating this entity from PMBL/DLBCL and CHL were presented. There was discussion regarding the clinical and genetic differences between mediastinal and non-mediastinal GZLs. Rare cases of PMBL and GZL associated with EBV or follicular lymphoma were reviewed. Finally, several cases included in the session highlighted composite or sequential CHL and PMBL/DLBCL and/or GZL, highlighting challenges in separating such cases from GZL.",
keywords = "B cell lymphoma, Unclassifiable, with features intermediate between diffuse large B cell lymphoma and classic Hodgkin lymphoma, Classic Hodgkin lymphoma, Composite lymphoma, Gray zone lymphoma, Mediastinal gray zone lymphoma, Primary mediastinal large B cell lymphoma",
author = "Gibson, {Sarah E.} and Stefan Docjinov and Snjezana Dotlic and Sylvia Hartmann and Hsi, {Eric D.} and Monika Klimkowska and Federica Melle and Pileri, {Stefano A.} and Ramsower, {Colleen A.} and Karen Rech and Rimsza, {Lisa M.} and Rodriguez-Pinilla, {Socorro Maria} and Tousseyn, {Thomas A.} and {de Jong}, Daphne and Elena Sabattini",
note = "Funding Information: This study was partially supported by the Associazione Italiana Ricerca sul Cancro (AIRC) grant no. 21198 (attributed to SAP), Associazione Italiana Linfomi-Leucemie e Mielomi di Bologna, Italy (Haematopathology Unit, Bologna). Funding Information: The authors gratefully acknowledge the case submitters for contributing materials and information for the cases in this session. The large collection of cases covering the differential diagnostic spectrum around PMBL that were submitted to this Workshop provided the unique opportunity for in depth analysis using state-of-the-art laboratory techniques. We would also like to thank the multiple colleagues who enabled and performed additional immunophenotyping and genomic analysis of selected cases: Lymph3Cx analysis performed by Dr. Lisa Rimsza and Colleen Ramsower, Mayo Clinic, Scottsdale, AZ, USA; immunohistochemistry performed by Dr. Karen Rech, Mayo Clinic, Rochester, AZ, UAS; immunohistochemistry, fluorescence in situ hybridization, and B cell clonality analysis performed by Dr. Simona Righi, University of Bologna, Bologna, Italy; next-generation sequencing performed by Dr. Giovanna Motta and Dr. Federica Melle, Institute of European Oncology, Milan, Italy; bioinformatic support by Andrea Franceschini. Publisher Copyright: {\textcopyright} 2023, The Author(s).",
year = "2023",
month = dec,
doi = "https://doi.org/10.1007/s00428-023-03550-5",
language = "English",
volume = "483",
pages = "733--749",
journal = "Virchows Archiv",
issn = "0945-6317",
publisher = "Springer Verlag",
number = "6",
}