Medication reviews and deprescribing as a single intervention in falls prevention: a systematic review and meta-analysis

Lotta J. Seppala; Nellie Kamkar; Eveline P. van Poelgeest; Katja Thomsen; Joost G. Daams; Jesper Ryg; Tahir Masud; Manuel Montero-Odasso; Sirpa Hartikainen; Mirko Petrovic; Nathalie van der Velde; Mirko Petrovic; Alice Nieuwboer; Ellen Vlaeyen; Koen Milisen; Jesper Ryg; Rose Anne Kenny; Robert Bourke; Sirpa Hartikainen; Tischa van der Cammen; Nathalie van der Velde; Eveline Poelgeest; Anton Jellema; Lotta J. Seppala; Tahir Masud; Chris Todd; Finbarr C. Martin; David R. Marsh; Sallie Lamb; James Frith; Pip Logan; Dawn Skelton; Hubert Blain; Cedric Anweiller; Ellen Freiberger; Clemens Becker; Lorenzo Chiari; Matteo Cesari; Alvaro Casas-Herrero; Javier Perez Jara; Christina Alonzo Bouzòn; Ana-Karim Welmer; Stephanie Birnghebuam; Reto Kressig; Manuel Montero-Odasso; Mark Speechley; Bill Mcilroy; Frederico Faria; Munira Sultana; Susan Muir-Hunter; Richard Camicioli; Kenneth Madden; Mireille Norris; Jennifer Watt; Louise Mallet; David Hogan; Joe Verghese; Ervin Sejdic; Luigi Ferruci; Lewis Lipsitz; David A. Ganz; Neil B. Alexander; Nancy Kathryn Latham; Fabiana Giber; Marcelo Schapira; Ricardo Jauregui; Felipe Melgar-Cuellar; Roberto Alves Lourenço; Daniela Cristina Carvalho de Abreu; Monica Perracini; Alejandro Ceriani; Pedro Marín-Larraín; Homero Gac Espinola; Jose Fernando Gómez-Montes; Carlos Alberto Cano-Gutierrez; Xinia Ramirez Ulate; Jose Ernesto Picado Ovares; Patricio Gabriel Buendia; Susana Lucia Tito; Diego Martínez Padilla; Sara G. Aguilar-Navarro; Alberto Mimenza; Rogelio Moctezum; Alberto Avila-Funes; Luis Miguel Gutierrez-Robledo; Luis Manuel Cornejo Alemán; Edgar Aguilera Caona; Juan Carlos Carbajal; Jose F. Parodi; Aldo Sgaravatti; Stephen Lord; Cathie Sherrington; Cathy Said; Ian Cameron; Meg Morris; Gustavo Duque; Jacqueline Close; Ngaire Kerse; Maw Pin Tan; Leilei Duan; Ryota Sakurai; Chek Hooi Wong; Irfan Muneeb; Hossein Negahban; Canan Birimoglu; Chang Won Won; Jeffrey Huasdorff; Sebastiana Kalula; Olive Kobusingye

doi:https://doi.org/10.1093/ageing/afac191

Medication reviews and deprescribing as a single intervention in falls prevention: a systematic review and meta-analysis

Lotta J. Seppala, Nellie Kamkar, Eveline P. van Poelgeest, Katja Thomsen, Joost G. Daams, Jesper Ryg, Tahir Masud, Manuel Montero-Odasso, Sirpa Hartikainen, Mirko Petrovic, Nathalie van der Velde, Mirko Petrovic, Alice Nieuwboer, Ellen Vlaeyen, Koen Milisen, Jesper Ryg, Rose Anne Kenny, Robert Bourke, Sirpa Hartikainen, Tischa van der CammenNathalie van der Velde, Eveline Poelgeest, Anton Jellema, Lotta J. Seppala, Tahir Masud, Chris Todd, Finbarr C. Martin, David R. Marsh, Sallie Lamb, James Frith, Pip Logan, Dawn Skelton, Hubert Blain, Cedric Anweiller, Ellen Freiberger, Clemens Becker, Lorenzo Chiari, Matteo Cesari, Alvaro Casas-Herrero, Javier Perez Jara, Christina Alonzo Bouzòn, Ana-Karim Welmer, Stephanie Birnghebuam, Reto Kressig, Manuel Montero-Odasso, Mark Speechley, Bill Mcilroy, Frederico Faria, Munira Sultana, Susan Muir-Hunter, Richard Camicioli, Kenneth Madden, Mireille Norris, Jennifer Watt, Louise Mallet, David Hogan, Joe Verghese, Ervin Sejdic, Luigi Ferruci, Lewis Lipsitz, David A. Ganz, Neil B. Alexander, Nancy Kathryn Latham, Fabiana Giber, Marcelo Schapira, Ricardo Jauregui, Felipe Melgar-Cuellar, Roberto Alves Lourenço, Daniela Cristina Carvalho de Abreu, Monica Perracini, Alejandro Ceriani, Pedro Marín-Larraín, Homero Gac Espinola, Jose Fernando Gómez-Montes, Carlos Alberto Cano-Gutierrez, Xinia Ramirez Ulate, Jose Ernesto Picado Ovares, Patricio Gabriel Buendia, Susana Lucia Tito, Diego Martínez Padilla, Sara G. Aguilar-Navarro, Alberto Mimenza, Rogelio Moctezum, Alberto Avila-Funes, Luis Miguel Gutierrez-Robledo, Luis Manuel Cornejo Alemán, Edgar Aguilera Caona, Juan Carlos Carbajal, Jose F. Parodi, Aldo Sgaravatti, Stephen Lord, Cathie Sherrington, Cathy Said, Ian Cameron, Meg Morris, Gustavo Duque, Jacqueline Close, Ngaire Kerse, Maw Pin Tan, Leilei Duan, Ryota Sakurai, Chek Hooi Wong, Irfan Muneeb, Hossein Negahban, Canan Birimoglu, Chang Won Won, Jeffrey Huasdorff, Sebastiana Kalula, Olive Kobusingye

Research output: Contribution to journal › Article › Academic › peer-review

9 Citations (Scopus)

Abstract

BACKGROUND: our aim was to assess the effectiveness of medication review and deprescribing interventions as a single intervention in falls prevention.

METHODS:

DESIGN: systematic review and meta-analysis.

DATA SOURCES: Medline, Embase, Cochrane CENTRAL, PsycINFO until 28 March 2022.

ELIGIBILITY CRITERIA: randomised controlled trials of older participants comparing any medication review or deprescribing intervention with usual care and reporting falls as an outcome.

STUDY RECORDS: title/abstract and full-text screening by two reviewers.

RISK OF BIAS: Cochrane Collaboration revised tool.

DATA SYNTHESIS: results reported separately for different settings and sufficiently comparable studies meta-analysed.

RESULTS: forty-nine heterogeneous studies were included.

COMMUNITY: meta-analyses of medication reviews resulted in a risk ratio (RR) of 1.05 (95% confidence interval, 0.85-1.29, I2 = 0%, 3 studies(s)) for number of fallers, in an RR = 0.95 (0.70-1.27, I2 = 37%, 3 s) for number of injurious fallers and in a rate ratio (RaR) of 0.89 (0.69-1.14, I2 = 0%, 2 s) for injurious falls.

HOSPITAL: meta-analyses assessing medication reviews resulted in an RR = 0.97 (0.74-1.28, I2 = 15%, 2 s) and in an RR = 0.50 (0.07-3.50, I2 = 72% %, 2 s) for number of fallers after and during admission, respectively.

LONG-TERM CARE: meta-analyses investigating medication reviews or deprescribing plans resulted in an RR = 0.86 (0.72-1.02, I2 = 0%, 5 s) for number of fallers and in an RaR = 0.93 (0.64-1.35, I2 = 92%, 7 s) for number of falls.

CONCLUSIONS: the heterogeneity of the interventions precluded us to estimate the exact effect of medication review and deprescribing as a single intervention. For future studies, more comparability is warranted. These interventions should not be implemented as a stand-alone strategy in falls prevention but included in multimodal strategies due to the multifactorial nature of falls.PROSPERO registration number: CRD42020218231.

Original language	English
Article number	afac191
Journal	Age and ageing
Volume	51
Issue number	9
DOIs	https://doi.org/10.1093/ageing/afac191
Publication status	Published - 1 Sept 2022

Keywords

Deprescriptions
Exercise
Hospitals
Humans
Medication Review

Access to Document

https://doi.org/10.1093/ageing/afac191

Cite this

Seppala, L. J., Kamkar, N., van Poelgeest, E. P., Thomsen, K., Daams, J. G., Ryg, J., Masud, T., Montero-Odasso, M., Hartikainen, S., Petrovic, M., van der Velde, N., Petrovic, M., Nieuwboer, A., Vlaeyen, E., Milisen, K., Ryg, J., Kenny, R. A., Bourke, R., Hartikainen, S., ... Kobusingye, O. (2022). Medication reviews and deprescribing as a single intervention in falls prevention: a systematic review and meta-analysis. Age and ageing, 51(9), Article afac191. https://doi.org/10.1093/ageing/afac191

@article{2604e1aa6de743628abaf557e934b64a,

title = "Medication reviews and deprescribing as a single intervention in falls prevention: a systematic review and meta-analysis",

abstract = "BACKGROUND: our aim was to assess the effectiveness of medication review and deprescribing interventions as a single intervention in falls prevention.METHODS: DESIGN: systematic review and meta-analysis.DATA SOURCES: Medline, Embase, Cochrane CENTRAL, PsycINFO until 28 March 2022.ELIGIBILITY CRITERIA: randomised controlled trials of older participants comparing any medication review or deprescribing intervention with usual care and reporting falls as an outcome.STUDY RECORDS: title/abstract and full-text screening by two reviewers.RISK OF BIAS: Cochrane Collaboration revised tool.DATA SYNTHESIS: results reported separately for different settings and sufficiently comparable studies meta-analysed.RESULTS: forty-nine heterogeneous studies were included.COMMUNITY: meta-analyses of medication reviews resulted in a risk ratio (RR) of 1.05 (95% confidence interval, 0.85-1.29, I2 = 0%, 3 studies(s)) for number of fallers, in an RR = 0.95 (0.70-1.27, I2 = 37%, 3 s) for number of injurious fallers and in a rate ratio (RaR) of 0.89 (0.69-1.14, I2 = 0%, 2 s) for injurious falls.HOSPITAL: meta-analyses assessing medication reviews resulted in an RR = 0.97 (0.74-1.28, I2 = 15%, 2 s) and in an RR = 0.50 (0.07-3.50, I2 = 72% %, 2 s) for number of fallers after and during admission, respectively.LONG-TERM CARE: meta-analyses investigating medication reviews or deprescribing plans resulted in an RR = 0.86 (0.72-1.02, I2 = 0%, 5 s) for number of fallers and in an RaR = 0.93 (0.64-1.35, I2 = 92%, 7 s) for number of falls.CONCLUSIONS: the heterogeneity of the interventions precluded us to estimate the exact effect of medication review and deprescribing as a single intervention. For future studies, more comparability is warranted. These interventions should not be implemented as a stand-alone strategy in falls prevention but included in multimodal strategies due to the multifactorial nature of falls.PROSPERO registration number: CRD42020218231.",

keywords = "Deprescriptions, Exercise, Hospitals, Humans, Medication Review",

author = "Seppala, {Lotta J.} and Nellie Kamkar and {van Poelgeest}, {Eveline P.} and Katja Thomsen and Daams, {Joost G.} and Jesper Ryg and Tahir Masud and Manuel Montero-Odasso and Sirpa Hartikainen and Mirko Petrovic and {van der Velde}, Nathalie and Mirko Petrovic and Alice Nieuwboer and Ellen Vlaeyen and Koen Milisen and Jesper Ryg and Kenny, {Rose Anne} and Robert Bourke and Sirpa Hartikainen and {van der Cammen}, Tischa and {van der Velde}, Nathalie and Eveline Poelgeest and Anton Jellema and Seppala, {Lotta J.} and Tahir Masud and Chris Todd and Martin, {Finbarr C.} and Marsh, {David R.} and Sallie Lamb and James Frith and Pip Logan and Dawn Skelton and Hubert Blain and Cedric Anweiller and Ellen Freiberger and Clemens Becker and Lorenzo Chiari and Matteo Cesari and Alvaro Casas-Herrero and {Perez Jara}, Javier and {Alonzo Bouz{\`o}n}, Christina and Ana-Karim Welmer and Stephanie Birnghebuam and Reto Kressig and Manuel Montero-Odasso and Mark Speechley and Bill Mcilroy and Frederico Faria and Munira Sultana and Susan Muir-Hunter and Richard Camicioli and Kenneth Madden and Mireille Norris and Jennifer Watt and Louise Mallet and David Hogan and Joe Verghese and Ervin Sejdic and Luigi Ferruci and Lewis Lipsitz and Ganz, {David A.} and Alexander, {Neil B.} and Latham, {Nancy Kathryn} and Fabiana Giber and Marcelo Schapira and Ricardo Jauregui and Felipe Melgar-Cuellar and {Alves Louren{\c c}o}, Roberto and {Carvalho de Abreu}, {Daniela Cristina} and Monica Perracini and Alejandro Ceriani and Pedro Mar{\'i}n-Larra{\'i}n and Espinola, {Homero Gac} and G{\'o}mez-Montes, {Jose Fernando} and Cano-Gutierrez, {Carlos Alberto} and Ulate, {Xinia Ramirez} and {Picado Ovares}, {Jose Ernesto} and {Gabriel Buendia}, Patricio and Tito, {Susana Lucia} and Padilla, {Diego Mart{\'i}nez} and Aguilar-Navarro, {Sara G.} and Alberto Mimenza and Rogelio Moctezum and Alberto Avila-Funes and Gutierrez-Robledo, {Luis Miguel} and {Cornejo Alem{\'a}n}, {Luis Manuel} and Caona, {Edgar Aguilera} and Carbajal, {Juan Carlos} and Parodi, {Jose F.} and Aldo Sgaravatti and Stephen Lord and Cathie Sherrington and Cathy Said and Ian Cameron and Meg Morris and Gustavo Duque and Jacqueline Close and Ngaire Kerse and Tan, {Maw Pin} and Leilei Duan and Ryota Sakurai and Wong, {Chek Hooi} and Irfan Muneeb and Hossein Negahban and Canan Birimoglu and Won, {Chang Won} and Jeffrey Huasdorff and Sebastiana Kalula and Olive Kobusingye",

note = "{\textcopyright} The Author(s) 2022. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissions@oup.com.",

year = "2022",

month = sep,

day = "1",

doi = "https://doi.org/10.1093/ageing/afac191",

language = "English",

volume = "51",

journal = "Age and ageing",

issn = "0002-0729",

publisher = "Oxford University Press",

number = "9",

}

Seppala, LJ, Kamkar, N, van Poelgeest, EP, Thomsen, K, Daams, JG, Ryg, J, Masud, T, Montero-Odasso, M, Hartikainen, S, Petrovic, M, van der Velde, N, Petrovic, M, Nieuwboer, A, Vlaeyen, E, Milisen, K, Ryg, J, Kenny, RA, Bourke, R, Hartikainen, S, van der Cammen, T, van der Velde, N, Poelgeest, E, Jellema, A, Seppala, LJ, Masud, T, Todd, C, Martin, FC, Marsh, DR, Lamb, S, Frith, J, Logan, P, Skelton, D, Blain, H, Anweiller, C, Freiberger, E, Becker, C, Chiari, L, Cesari, M, Casas-Herrero, A, Perez Jara, J, Alonzo Bouzòn, C, Welmer, A-K, Birnghebuam, S, Kressig, R, Montero-Odasso, M, Speechley, M, Mcilroy, B, Faria, F, Sultana, M, Muir-Hunter, S, Camicioli, R, Madden, K, Norris, M, Watt, J, Mallet, L, Hogan, D, Verghese, J, Sejdic, E, Ferruci, L, Lipsitz, L, Ganz, DA, Alexander, NB, Latham, NK, Giber, F, Schapira, M, Jauregui, R, Melgar-Cuellar, F, Alves Lourenço, R, Carvalho de Abreu, DC, Perracini, M, Ceriani, A, Marín-Larraín, P, Espinola, HG, Gómez-Montes, JF, Cano-Gutierrez, CA, Ulate, XR, Picado Ovares, JE, Gabriel Buendia, P, Tito, SL, Padilla, DM, Aguilar-Navarro, SG, Mimenza, A, Moctezum, R, Avila-Funes, A, Gutierrez-Robledo, LM, Cornejo Alemán, LM, Caona, EA, Carbajal, JC, Parodi, JF, Sgaravatti, A, Lord, S, Sherrington, C, Said, C, Cameron, I, Morris, M, Duque, G, Close, J, Kerse, N, Tan, MP, Duan, L, Sakurai, R, Wong, CH, Muneeb, I, Negahban, H, Birimoglu, C, Won, CW, Huasdorff, J, Kalula, S & Kobusingye, O 2022, 'Medication reviews and deprescribing as a single intervention in falls prevention: a systematic review and meta-analysis', Age and ageing, vol. 51, no. 9, afac191. https://doi.org/10.1093/ageing/afac191

TY - JOUR

T1 - Medication reviews and deprescribing as a single intervention in falls prevention

T2 - a systematic review and meta-analysis

AU - Seppala, Lotta J.

AU - Kamkar, Nellie

AU - van Poelgeest, Eveline P.

AU - Thomsen, Katja

AU - Daams, Joost G.

AU - Ryg, Jesper

AU - Masud, Tahir

AU - Montero-Odasso, Manuel

AU - Hartikainen, Sirpa

AU - Petrovic, Mirko

AU - van der Velde, Nathalie

AU - Petrovic, Mirko

AU - Nieuwboer, Alice

AU - Vlaeyen, Ellen

AU - Milisen, Koen

AU - Ryg, Jesper

AU - Kenny, Rose Anne

AU - Bourke, Robert

AU - Hartikainen, Sirpa

AU - van der Cammen, Tischa

AU - van der Velde, Nathalie

AU - Poelgeest, Eveline

AU - Jellema, Anton

AU - Seppala, Lotta J.

AU - Masud, Tahir

AU - Todd, Chris

AU - Martin, Finbarr C.

AU - Marsh, David R.

AU - Lamb, Sallie

AU - Frith, James

AU - Logan, Pip

AU - Skelton, Dawn

AU - Blain, Hubert

AU - Anweiller, Cedric

AU - Freiberger, Ellen

AU - Becker, Clemens

AU - Chiari, Lorenzo

AU - Cesari, Matteo

AU - Casas-Herrero, Alvaro

AU - Perez Jara, Javier

AU - Alonzo Bouzòn, Christina

AU - Welmer, Ana-Karim

AU - Birnghebuam, Stephanie

AU - Kressig, Reto

AU - Montero-Odasso, Manuel

AU - Speechley, Mark

AU - Mcilroy, Bill

AU - Faria, Frederico

AU - Sultana, Munira

AU - Muir-Hunter, Susan

AU - Camicioli, Richard

AU - Madden, Kenneth

AU - Norris, Mireille

AU - Watt, Jennifer

AU - Mallet, Louise

AU - Hogan, David

AU - Verghese, Joe

AU - Sejdic, Ervin

AU - Ferruci, Luigi

AU - Lipsitz, Lewis

AU - Ganz, David A.

AU - Alexander, Neil B.

AU - Latham, Nancy Kathryn

AU - Giber, Fabiana

AU - Schapira, Marcelo

AU - Jauregui, Ricardo

AU - Melgar-Cuellar, Felipe

AU - Alves Lourenço, Roberto

AU - Carvalho de Abreu, Daniela Cristina

AU - Perracini, Monica

AU - Ceriani, Alejandro

AU - Marín-Larraín, Pedro

AU - Espinola, Homero Gac

AU - Gómez-Montes, Jose Fernando

AU - Cano-Gutierrez, Carlos Alberto

AU - Ulate, Xinia Ramirez

AU - Picado Ovares, Jose Ernesto

AU - Gabriel Buendia, Patricio

AU - Tito, Susana Lucia

AU - Padilla, Diego Martínez

AU - Aguilar-Navarro, Sara G.

AU - Mimenza, Alberto

AU - Moctezum, Rogelio

AU - Avila-Funes, Alberto

AU - Gutierrez-Robledo, Luis Miguel

AU - Cornejo Alemán, Luis Manuel

AU - Caona, Edgar Aguilera

AU - Carbajal, Juan Carlos

AU - Parodi, Jose F.

AU - Sgaravatti, Aldo

AU - Lord, Stephen

AU - Sherrington, Cathie

AU - Said, Cathy

AU - Cameron, Ian

AU - Morris, Meg

AU - Duque, Gustavo

AU - Close, Jacqueline

AU - Kerse, Ngaire

AU - Tan, Maw Pin

AU - Duan, Leilei

AU - Sakurai, Ryota

AU - Wong, Chek Hooi

AU - Muneeb, Irfan

AU - Negahban, Hossein

AU - Birimoglu, Canan

AU - Won, Chang Won

AU - Huasdorff, Jeffrey

AU - Kalula, Sebastiana

AU - Kobusingye, Olive

PY - 2022/9/1

Y1 - 2022/9/1

N2 - BACKGROUND: our aim was to assess the effectiveness of medication review and deprescribing interventions as a single intervention in falls prevention.METHODS: DESIGN: systematic review and meta-analysis.DATA SOURCES: Medline, Embase, Cochrane CENTRAL, PsycINFO until 28 March 2022.ELIGIBILITY CRITERIA: randomised controlled trials of older participants comparing any medication review or deprescribing intervention with usual care and reporting falls as an outcome.STUDY RECORDS: title/abstract and full-text screening by two reviewers.RISK OF BIAS: Cochrane Collaboration revised tool.DATA SYNTHESIS: results reported separately for different settings and sufficiently comparable studies meta-analysed.RESULTS: forty-nine heterogeneous studies were included.COMMUNITY: meta-analyses of medication reviews resulted in a risk ratio (RR) of 1.05 (95% confidence interval, 0.85-1.29, I2 = 0%, 3 studies(s)) for number of fallers, in an RR = 0.95 (0.70-1.27, I2 = 37%, 3 s) for number of injurious fallers and in a rate ratio (RaR) of 0.89 (0.69-1.14, I2 = 0%, 2 s) for injurious falls.HOSPITAL: meta-analyses assessing medication reviews resulted in an RR = 0.97 (0.74-1.28, I2 = 15%, 2 s) and in an RR = 0.50 (0.07-3.50, I2 = 72% %, 2 s) for number of fallers after and during admission, respectively.LONG-TERM CARE: meta-analyses investigating medication reviews or deprescribing plans resulted in an RR = 0.86 (0.72-1.02, I2 = 0%, 5 s) for number of fallers and in an RaR = 0.93 (0.64-1.35, I2 = 92%, 7 s) for number of falls.CONCLUSIONS: the heterogeneity of the interventions precluded us to estimate the exact effect of medication review and deprescribing as a single intervention. For future studies, more comparability is warranted. These interventions should not be implemented as a stand-alone strategy in falls prevention but included in multimodal strategies due to the multifactorial nature of falls.PROSPERO registration number: CRD42020218231.

AB - BACKGROUND: our aim was to assess the effectiveness of medication review and deprescribing interventions as a single intervention in falls prevention.METHODS: DESIGN: systematic review and meta-analysis.DATA SOURCES: Medline, Embase, Cochrane CENTRAL, PsycINFO until 28 March 2022.ELIGIBILITY CRITERIA: randomised controlled trials of older participants comparing any medication review or deprescribing intervention with usual care and reporting falls as an outcome.STUDY RECORDS: title/abstract and full-text screening by two reviewers.RISK OF BIAS: Cochrane Collaboration revised tool.DATA SYNTHESIS: results reported separately for different settings and sufficiently comparable studies meta-analysed.RESULTS: forty-nine heterogeneous studies were included.COMMUNITY: meta-analyses of medication reviews resulted in a risk ratio (RR) of 1.05 (95% confidence interval, 0.85-1.29, I2 = 0%, 3 studies(s)) for number of fallers, in an RR = 0.95 (0.70-1.27, I2 = 37%, 3 s) for number of injurious fallers and in a rate ratio (RaR) of 0.89 (0.69-1.14, I2 = 0%, 2 s) for injurious falls.HOSPITAL: meta-analyses assessing medication reviews resulted in an RR = 0.97 (0.74-1.28, I2 = 15%, 2 s) and in an RR = 0.50 (0.07-3.50, I2 = 72% %, 2 s) for number of fallers after and during admission, respectively.LONG-TERM CARE: meta-analyses investigating medication reviews or deprescribing plans resulted in an RR = 0.86 (0.72-1.02, I2 = 0%, 5 s) for number of fallers and in an RaR = 0.93 (0.64-1.35, I2 = 92%, 7 s) for number of falls.CONCLUSIONS: the heterogeneity of the interventions precluded us to estimate the exact effect of medication review and deprescribing as a single intervention. For future studies, more comparability is warranted. These interventions should not be implemented as a stand-alone strategy in falls prevention but included in multimodal strategies due to the multifactorial nature of falls.PROSPERO registration number: CRD42020218231.

KW - Deprescriptions

KW - Exercise

KW - Hospitals

KW - Humans

KW - Medication Review

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85153116481&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/36153749

U2 - https://doi.org/10.1093/ageing/afac191

DO - https://doi.org/10.1093/ageing/afac191

M3 - Article

C2 - 36153749

SN - 0002-0729

VL - 51

JO - Age and ageing

JF - Age and ageing

IS - 9

M1 - afac191

ER -

Medication reviews and deprescribing as a single intervention in falls prevention: a systematic review and meta-analysis

Abstract

Keywords

Access to Document

Other files and links

Cite this