TY - JOUR
T1 - Mesial temporal tau is related to worse cognitive performance and greater neocortical tau load in amyloid-β–negative cognitively normal individuals
AU - Groot, Colin
AU - Doré, Vincent
AU - Robertson, Joanne
AU - Burnham, Samantha C.
AU - Savage, Greg
AU - Ossenkoppele, Rik
AU - Rowe, Christopher C.
AU - Villemagne, Victor L.
N1 - Funding Information: C.C.R. reports speaker honoraria from GE Healthcare and Avid Radiopharmaceuticals, consulting fees from Avid Radiopharmaceuticals, AstraZeneca, and Piramal Imaging, and research grants from Avid Radiopharmaceuticals, GE Healthcare, and Piramal Imaging all outside the scope of the submitted work. V.L.V. reports speaker honoraria from GE Healthcare, Piramal Imaging, and Avid Radiopharmaceuticals, and consulting fees from Lundbeck, AbbVie, Shanghai Green Valley Co, IXICO, and Hoffmann La Roche, all outside the scope of the submitted work. C.G., V.D., J.R., S.B., G.S., and R.O. report no disclosures. Funding Information: Funding: The study received a research fellowship grant from Alzheimer Nederland ( WE.15-2018-02 , CG), and research support from the National Health and Medical Research Council (NHMRC), Avid Radiopharmaceuticals (Eli Lilly) and the National Institute on Aging of the National Institutes of Health within the Department of Health and Human Services in the United States of America ( R01 AG029672 , RO). The funding sources did not have any involvement or influence in study design, data production, data analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2020 Elsevier Inc. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - We examined whether mesial temporal (Me) tau relates to cognitive performance in 47 amyloid-β (Aβ)-negative, cognitively normal older adults (>60 years old). Me-tau was measured using [18F]flortaucipir–positron emission tomography standardized uptake value ratio. The effect of continuous and categorical (stratified at standardized uptake value ratio = 1.2 [21% Me-positive]) Me-tau on cognition (mini-mental state examination, pre-Alzheimer's cognitive composite, a memory composite, and a nonmemory composite score) was examined using general linear models, and associations between Me-tau and [18F]flortaucipir signal in the neocortex were assessed using voxelwise regressions (continuous) and voxelwise contrasts (categorical). In addition, we assessed the effect of age and Aβ burden on Me-tau. Both continuous and categorical Me-tau was associated with worse cognitive performance across all tests and with higher lateral temporal and parietal [18F]flortaucipir signal. Furthermore, we observed a marginal association between Me-tau and age, whereas there was no association with Aβ burden. Our findings indicate that Me-tau in Aβ-negative cognitively normal individuals, which is likely age-related (i.e., primary age-related tauopathy), might not be as benign as commonly thought.
AB - We examined whether mesial temporal (Me) tau relates to cognitive performance in 47 amyloid-β (Aβ)-negative, cognitively normal older adults (>60 years old). Me-tau was measured using [18F]flortaucipir–positron emission tomography standardized uptake value ratio. The effect of continuous and categorical (stratified at standardized uptake value ratio = 1.2 [21% Me-positive]) Me-tau on cognition (mini-mental state examination, pre-Alzheimer's cognitive composite, a memory composite, and a nonmemory composite score) was examined using general linear models, and associations between Me-tau and [18F]flortaucipir signal in the neocortex were assessed using voxelwise regressions (continuous) and voxelwise contrasts (categorical). In addition, we assessed the effect of age and Aβ burden on Me-tau. Both continuous and categorical Me-tau was associated with worse cognitive performance across all tests and with higher lateral temporal and parietal [18F]flortaucipir signal. Furthermore, we observed a marginal association between Me-tau and age, whereas there was no association with Aβ burden. Our findings indicate that Me-tau in Aβ-negative cognitively normal individuals, which is likely age-related (i.e., primary age-related tauopathy), might not be as benign as commonly thought.
KW - Mesial temporal lobe
KW - PART
KW - PET
KW - Tau
UR - http://www.scopus.com/inward/record.url?scp=85094187018&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.neurobiolaging.2020.09.017
DO - https://doi.org/10.1016/j.neurobiolaging.2020.09.017
M3 - Article
C2 - 33130455
SN - 0197-4580
VL - 97
SP - 41
EP - 48
JO - Neurobiology of Aging
JF - Neurobiology of Aging
ER -