Metabolic Alterations in Aging Macrophages: Ingredients for Inflammaging?

Adriaan A. van Beek, Jan van den Bossche, Pier G. Mastroberardino, Menno P. J. de Winther, Pieter J. M. Leenen

Research output: Contribution to journalReview articleAcademicpeer-review

127 Citations (Scopus)


Aging is a complex process with an impact on essentially all organs. Declined cellular repair causes increased damage at genomic and proteomic levels upon aging. This can lead to systemic changes in metabolism and pro-inflammatory cytokine production, resulting in low-grade inflammation, or ‘inflammaging’. Tissue macrophages, gatekeepers of parenchymal homeostasis and integrity, are prime inflammatory cytokine producers, as well as initiators and regulators of inflammation. In this opinion piece, we summarize intrinsic alterations in macrophage phenotype and function with age. We propose that alternatively activated macrophages (M2-like), which are yet pro-inflammatory, can accumulate in tissues and promote inflammaging. Age-related increases in endoplasmic reticulum stress and mitochondrial dysfunction might be cell-intrinsic forces driving this unusual phenotype.
Original languageEnglish
Pages (from-to)113-127
Number of pages15
JournalTrends in immunology
Issue number2
Publication statusPublished - 1 Feb 2019


  • aging
  • cell metabolism
  • epigenetics
  • inflammation
  • macrophages

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