TY - JOUR
T1 - Metabolism and Metabolic Disorders and the Microbiome: The Intestinal Microbiota Associated With Obesity, Lipid Metabolism, and Metabolic Health—Pathophysiology and Therapeutic Strategies
T2 - The Intestinal Microbiota Associated With Obesity, Lipid Metabolism, and Metabolic Health: Pathophysiology and Therapeutic Strategies
AU - Aron-Wisnewsky, Judith
AU - Warmbrunn, Moritz V.
AU - Nieuwdorp, Max
AU - Clément, Karine
N1 - Copyright © 2020 AGA Institute. Published by Elsevier Inc. All rights reserved.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - Changes in the intestinal microbiome have been associated with obesity and type 2 diabetes, in epidemiological studies and studies of the effects of fecal transfer in germ-free mice. We review the mechanisms by which alterations in the intestinal microbiome contribute to development of metabolic diseases, and recent advances, such as the effects of the microbiome on lipid metabolism. Strategies have been developed to modify the intestinal microbiome and reverse metabolic alterations, which might be used as therapies. We discuss approaches that have shown effects in mouse models of obesity and metabolic disorders, and how these might be translated to humans to improve metabolic health.
AB - Changes in the intestinal microbiome have been associated with obesity and type 2 diabetes, in epidemiological studies and studies of the effects of fecal transfer in germ-free mice. We review the mechanisms by which alterations in the intestinal microbiome contribute to development of metabolic diseases, and recent advances, such as the effects of the microbiome on lipid metabolism. Strategies have been developed to modify the intestinal microbiome and reverse metabolic alterations, which might be used as therapies. We discuss approaches that have shown effects in mouse models of obesity and metabolic disorders, and how these might be translated to humans to improve metabolic health.
KW - Insulin Resistance
KW - Intestinal Microbiome
KW - Lipids
KW - Microbial-Derived Metabolites
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=85099694558&partnerID=8YFLogxK
U2 - https://doi.org/10.1053/j.gastro.2020.10.057
DO - https://doi.org/10.1053/j.gastro.2020.10.057
M3 - Article
C2 - 33253685
SN - 0016-5085
VL - 160
SP - 573
EP - 599
JO - Gastroenterology
JF - Gastroenterology
IS - 2
ER -