Mice lacking the multidrug resistance protein 1 have a transiently impaired immune response during tuberculosis

A. Verbon; J. C. Leemans; S. Weijer; S. Florquin; T. van der Poll

doi:https://doi.org/10.1046/j.1365-2249.2002.01952.x

Mice lacking the multidrug resistance protein 1 have a transiently impaired immune response during tuberculosis

A. Verbon, J. C. Leemans, S. Weijer, S. Florquin, T. van der Poll

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

A T helper (Th) 1 immune response is important for host defense against tuberculosis. The multidrug resistance protein (Mrp) 1 is constitutively present at low levels on Th2 lymphocytes, and is expressed on Th1 lymphocytes upon activation. To determine the role of Mrp1 in the pathogenesis of tuberculosis, Mrp1 deficient (-/-) and normal wild type mice were intranasally infected with Mycobacterium tuberculosis . At 2 weeks after infection, Mrp1(-/-) mice had reduced levels of the Th1 cytokine interferon-gamma and an impaired granuloma formation in their lungs. At 5 weeks postinfection, M. tuberculosis outgrowth was enhanced in lungs and livers of Mrp1(-/-) mice. A more prolonged observation of these mice, up to 4 months, revealed no differences in survival or mycobacterial outgrowth. These data suggest that Mrp1 plays an early but dispensable role in the protective immune response to pulmonary tuberculosis

Original language	English
Pages (from-to)	32-36
Journal	Clinical and experimental immunology
Volume	130
Issue number	1
DOIs	https://doi.org/10.1046/j.1365-2249.2002.01952.x
Publication status	Published - 2002

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https://doi.org/10.1046/j.1365-2249.2002.01952.x

Cite this

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title = "Mice lacking the multidrug resistance protein 1 have a transiently impaired immune response during tuberculosis",

abstract = "A T helper (Th) 1 immune response is important for host defense against tuberculosis. The multidrug resistance protein (Mrp) 1 is constitutively present at low levels on Th2 lymphocytes, and is expressed on Th1 lymphocytes upon activation. To determine the role of Mrp1 in the pathogenesis of tuberculosis, Mrp1 deficient (-/-) and normal wild type mice were intranasally infected with Mycobacterium tuberculosis . At 2 weeks after infection, Mrp1(-/-) mice had reduced levels of the Th1 cytokine interferon-gamma and an impaired granuloma formation in their lungs. At 5 weeks postinfection, M. tuberculosis outgrowth was enhanced in lungs and livers of Mrp1(-/-) mice. A more prolonged observation of these mice, up to 4 months, revealed no differences in survival or mycobacterial outgrowth. These data suggest that Mrp1 plays an early but dispensable role in the protective immune response to pulmonary tuberculosis",

author = "A. Verbon and Leemans, {J. C.} and S. Weijer and S. Florquin and {van der Poll}, T.",

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T1 - Mice lacking the multidrug resistance protein 1 have a transiently impaired immune response during tuberculosis

AU - Verbon, A.

AU - Leemans, J. C.

AU - Weijer, S.

AU - Florquin, S.

AU - van der Poll, T.

PY - 2002

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AB - A T helper (Th) 1 immune response is important for host defense against tuberculosis. The multidrug resistance protein (Mrp) 1 is constitutively present at low levels on Th2 lymphocytes, and is expressed on Th1 lymphocytes upon activation. To determine the role of Mrp1 in the pathogenesis of tuberculosis, Mrp1 deficient (-/-) and normal wild type mice were intranasally infected with Mycobacterium tuberculosis . At 2 weeks after infection, Mrp1(-/-) mice had reduced levels of the Th1 cytokine interferon-gamma and an impaired granuloma formation in their lungs. At 5 weeks postinfection, M. tuberculosis outgrowth was enhanced in lungs and livers of Mrp1(-/-) mice. A more prolonged observation of these mice, up to 4 months, revealed no differences in survival or mycobacterial outgrowth. These data suggest that Mrp1 plays an early but dispensable role in the protective immune response to pulmonary tuberculosis

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DO - https://doi.org/10.1046/j.1365-2249.2002.01952.x

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