Microarray techniques in pathology: Tool or toy?

A. M. Snijders; G. A. Meijer; R. H. Brakenhoff; A. J.C. Van den Brule; P. J. Van Diest

doi:https://doi.org/10.1136/mp.53.6.289

Microarray techniques in pathology: Tool or toy?

A. M. Snijders, G. A. Meijer, R. H. Brakenhoff, A. J.C. Van den Brule, P. J. Van Diest

Research output: Contribution to journal › Review article › Academic › peer-review

1 Citation (Scopus)

Abstract

Microarray technology allows the simultaneous analysis of up to thousands of different genes in histological or cytological specimens. Although microarray technology has so far mainly been applied in the research setting, its clinical application in pathology is expected in the foreseeable future. This paper presents an overview of the technical 'ins and outs' of microarray technology, and discusses several putative applications in diagnostic pathology, which include tumour classification, the prediction of responses to certain chemotherapeutical or hormonal agents, the biological staging of tumours, the risk assessment of premalignant lesions, and the detection of microorganisms.

Original language	English
Pages (from-to)	289-294
Number of pages	6
Journal	Journal of Clinical Pathology - Molecular Pathology
Volume	53
Issue number	6
DOIs	https://doi.org/10.1136/mp.53.6.289
Publication status	Published - 2000

Keywords

Comparative genomic hybridisation
Diagnostic pathology
Gene expression
Gene sequencing
Microarray technology

Access to Document

https://doi.org/10.1136/mp.53.6.289

Cite this

@article{3329aa7cc4ba4daea7dc259ae8447411,

title = "Microarray techniques in pathology: Tool or toy?",

abstract = "Microarray technology allows the simultaneous analysis of up to thousands of different genes in histological or cytological specimens. Although microarray technology has so far mainly been applied in the research setting, its clinical application in pathology is expected in the foreseeable future. This paper presents an overview of the technical 'ins and outs' of microarray technology, and discusses several putative applications in diagnostic pathology, which include tumour classification, the prediction of responses to certain chemotherapeutical or hormonal agents, the biological staging of tumours, the risk assessment of premalignant lesions, and the detection of microorganisms.",

keywords = "Comparative genomic hybridisation, Diagnostic pathology, Gene expression, Gene sequencing, Microarray technology",

author = "Snijders, {A. M.} and Meijer, {G. A.} and Brakenhoff, {R. H.} and {Van den Brule}, {A. J.C.} and {Van Diest}, {P. J.}",

year = "2000",

doi = "https://doi.org/10.1136/mp.53.6.289",

language = "English",

volume = "53",

pages = "289--294",

journal = "Modern pathology",

issn = "0893-3952",

publisher = "Nature Publishing Group",

number = "6",

}

TY - JOUR

T1 - Microarray techniques in pathology

T2 - Tool or toy?

AU - Snijders, A. M.

AU - Meijer, G. A.

AU - Brakenhoff, R. H.

AU - Van den Brule, A. J.C.

AU - Van Diest, P. J.

PY - 2000

Y1 - 2000

N2 - Microarray technology allows the simultaneous analysis of up to thousands of different genes in histological or cytological specimens. Although microarray technology has so far mainly been applied in the research setting, its clinical application in pathology is expected in the foreseeable future. This paper presents an overview of the technical 'ins and outs' of microarray technology, and discusses several putative applications in diagnostic pathology, which include tumour classification, the prediction of responses to certain chemotherapeutical or hormonal agents, the biological staging of tumours, the risk assessment of premalignant lesions, and the detection of microorganisms.

AB - Microarray technology allows the simultaneous analysis of up to thousands of different genes in histological or cytological specimens. Although microarray technology has so far mainly been applied in the research setting, its clinical application in pathology is expected in the foreseeable future. This paper presents an overview of the technical 'ins and outs' of microarray technology, and discusses several putative applications in diagnostic pathology, which include tumour classification, the prediction of responses to certain chemotherapeutical or hormonal agents, the biological staging of tumours, the risk assessment of premalignant lesions, and the detection of microorganisms.

KW - Comparative genomic hybridisation

KW - Diagnostic pathology

KW - Gene expression

KW - Gene sequencing

KW - Microarray technology

UR - http://www.scopus.com/inward/record.url?scp=0033664021&partnerID=8YFLogxK

U2 - https://doi.org/10.1136/mp.53.6.289

DO - https://doi.org/10.1136/mp.53.6.289

M3 - Review article

C2 - 11193046

SN - 0893-3952

VL - 53

SP - 289

EP - 294

JO - Modern pathology

JF - Modern pathology

IS - 6

ER -

Microarray techniques in pathology: Tool or toy?

Abstract

Keywords

Access to Document

Other files and links

Cite this