MicroRNAs: role and therapeutic targets in viral hepatitis

Meike H. van der Ree; Joep de Bruijne; Neeltje A. Kootstra; Peter Lm Jansen; Hendrik W. Reesink

doi:https://doi.org/10.3851/IMP2766

MicroRNAs: role and therapeutic targets in viral hepatitis

Meike H. van der Ree, Joep de Bruijne, Neeltje A. Kootstra, Peter Lm Jansen, Hendrik W. Reesink

Research output: Contribution to journal › Review article › Academic › peer-review

10 Citations (Scopus)

Abstract

MicroRNAs regulate gene expression by binding to the 3'-untranslated region (UTR) of target messenger RNAs (mRNAs). The importance of microRNAs has been shown for several liver diseases, for example, viral hepatitis. MicroRNA-122 is highly abundant in the liver and is involved in the regulation of lipid metabolism. MicroRNA-122 is also an important host factor for the HCV and promotes HCV replication. In contrast to HCV, microRNA-122 inhibits replication of the HBV. MicroRNA-122 acts as a tumour suppressor and reduced levels of microRNA-122 are associated with hepatocellular carcinoma. MicroRNAs other than microRNA-122 have been linked to viral hepatitis, fibrosis and inflammation. In this review, we discuss function and clinical implications of microRNA-122 and other microRNAs in liver diseases, especially viral hepatitis

Original language	English
Pages (from-to)	533-541
Journal	Antiviral therapy
Volume	19
Issue number	6
DOIs	https://doi.org/10.3851/IMP2766
Publication status	Published - 2014

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https://doi.org/10.3851/IMP2766

Cite this

@article{1042e1f83aa8492baa46b74eb2d02154,

title = "MicroRNAs: role and therapeutic targets in viral hepatitis",

abstract = "MicroRNAs regulate gene expression by binding to the 3'-untranslated region (UTR) of target messenger RNAs (mRNAs). The importance of microRNAs has been shown for several liver diseases, for example, viral hepatitis. MicroRNA-122 is highly abundant in the liver and is involved in the regulation of lipid metabolism. MicroRNA-122 is also an important host factor for the HCV and promotes HCV replication. In contrast to HCV, microRNA-122 inhibits replication of the HBV. MicroRNA-122 acts as a tumour suppressor and reduced levels of microRNA-122 are associated with hepatocellular carcinoma. MicroRNAs other than microRNA-122 have been linked to viral hepatitis, fibrosis and inflammation. In this review, we discuss function and clinical implications of microRNA-122 and other microRNAs in liver diseases, especially viral hepatitis",

author = "{van der Ree}, {Meike H.} and {de Bruijne}, Joep and Kootstra, {Neeltje A.} and Jansen, {Peter Lm} and Reesink, {Hendrik W.}",

year = "2014",

doi = "https://doi.org/10.3851/IMP2766",

language = "English",

volume = "19",

pages = "533--541",

journal = "Antiviral therapy",

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publisher = "International Medical Press Ltd",

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TY - JOUR

T1 - MicroRNAs: role and therapeutic targets in viral hepatitis

AU - van der Ree, Meike H.

AU - de Bruijne, Joep

AU - Kootstra, Neeltje A.

AU - Jansen, Peter Lm

AU - Reesink, Hendrik W.

PY - 2014

Y1 - 2014

N2 - MicroRNAs regulate gene expression by binding to the 3'-untranslated region (UTR) of target messenger RNAs (mRNAs). The importance of microRNAs has been shown for several liver diseases, for example, viral hepatitis. MicroRNA-122 is highly abundant in the liver and is involved in the regulation of lipid metabolism. MicroRNA-122 is also an important host factor for the HCV and promotes HCV replication. In contrast to HCV, microRNA-122 inhibits replication of the HBV. MicroRNA-122 acts as a tumour suppressor and reduced levels of microRNA-122 are associated with hepatocellular carcinoma. MicroRNAs other than microRNA-122 have been linked to viral hepatitis, fibrosis and inflammation. In this review, we discuss function and clinical implications of microRNA-122 and other microRNAs in liver diseases, especially viral hepatitis

AB - MicroRNAs regulate gene expression by binding to the 3'-untranslated region (UTR) of target messenger RNAs (mRNAs). The importance of microRNAs has been shown for several liver diseases, for example, viral hepatitis. MicroRNA-122 is highly abundant in the liver and is involved in the regulation of lipid metabolism. MicroRNA-122 is also an important host factor for the HCV and promotes HCV replication. In contrast to HCV, microRNA-122 inhibits replication of the HBV. MicroRNA-122 acts as a tumour suppressor and reduced levels of microRNA-122 are associated with hepatocellular carcinoma. MicroRNAs other than microRNA-122 have been linked to viral hepatitis, fibrosis and inflammation. In this review, we discuss function and clinical implications of microRNA-122 and other microRNAs in liver diseases, especially viral hepatitis

U2 - https://doi.org/10.3851/IMP2766

DO - https://doi.org/10.3851/IMP2766

M3 - Review article

C2 - 24642660

SN - 1359-6535

VL - 19

SP - 533

EP - 541

JO - Antiviral therapy

JF - Antiviral therapy

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