Microvascular dysfunction in obesity: A potential mechanism in the pathogenesis of obesity-associated insulin resistance and hypertension

Amy M. Jonk, Alfons J.H.M. Houben, Renate T. De Jongh, Erik H. Serné, Nicoloaas C. Schaper, Coen D.A. Stehouwer

Research output: Contribution to journalReview articleAcademicpeer-review

215 Citations (Scopus)


Obesity is an important risk factor for insulin resistance and hypertension and plays a central role in the metabolic syndrome. Insight into the pathophysiology of this syndrome may lead to new treatments. This paper has reviewed the evidence for an important role for the microcirculation as a possible link between obesity, insulin resistance and hypertension.

Original languageEnglish
Pages (from-to)252-260
Number of pages9
Issue number4
Publication statusPublished - 1 Aug 2007

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