Migration history and risk of psychosis: results from the multinational EU-GEI study

Ilaria Tarricone; Giuseppe D'Andrea; Hannah E Jongsma; Sarah Tosato; Charlotte Gayer-Anderson; Simona A Stilo; Federico Suprani; Conrad Iyegbe; Els van der Ven; Diego Quattrone; Marta di Forti; Eva Velthorst; Paulo Rossi Menezes; Celso Arango; Mara Parellada; Antonio Lasalvia; Caterina La Cascia; Laura Ferraro; Julio Bobes; Miguel Bernardo; Iulio Sanjuán; Jose Luis Santos; Manuel Arrojo; Cristina Marta Del-Ben; Giada Tripoli; Pierre-Michel Llorca; Lieuwe de Haan; Jean-Paul Selten; Andrea Tortelli; Andrei Szöke; Roberto Muratori; Bart P Rutten; Jim van Os; Peter B Jones; James B Kirkbride; Domenico Berardi; Robin M Murray; Craig Morgan

doi:https://doi.org/10.1017/S003329172000495X

Migration history and risk of psychosis: results from the multinational EU-GEI study

Ilaria Tarricone, Giuseppe D'Andrea, Hannah E Jongsma, Sarah Tosato, Charlotte Gayer-Anderson, Simona A Stilo, Federico Suprani, Conrad Iyegbe, Els van der Ven, Diego Quattrone, Marta di Forti, Eva Velthorst, Paulo Rossi Menezes, Celso Arango, Mara Parellada, Antonio Lasalvia, Caterina La Cascia, Laura Ferraro, Julio Bobes, Miguel BernardoIulio Sanjuán, Jose Luis Santos, Manuel Arrojo, Cristina Marta Del-Ben, Giada Tripoli, Pierre-Michel Llorca, Lieuwe de Haan, Jean-Paul Selten, Andrea Tortelli, Andrei Szöke, Roberto Muratori, Bart P Rutten, Jim van Os, Peter B Jones, James B Kirkbride, Domenico Berardi, Robin M Murray, Craig Morgan

Research output: Contribution to journal › Article › Academic › peer-review

18 Citations (Scopus)

Abstract

BACKGROUND: Psychosis rates are higher among some migrant groups. We hypothesized that psychosis in migrants is associated with cumulative social disadvantage during different phases of migration.

METHODS: We used data from the EUropean Network of National Schizophrenia Networks studying Gene-Environment Interactions (EU-GEI) case-control study. We defined a set of three indicators of social disadvantage for each phase: pre-migration, migration and post-migration. We examined whether social disadvantage in the pre- and post-migration phases, migration adversities, and mismatch between achievements and expectations differed between first-generation migrants with first-episode psychosis and healthy first-generation migrants, and tested whether this accounted for differences in odds of psychosis in multivariable logistic regression models.

RESULTS: In total, 249 cases and 219 controls were assessed. Pre-migration (OR 1.61, 95% CI 1.06-2.44, p = 0.027) and post-migration social disadvantages (OR 1.89, 95% CI 1.02-3.51, p = 0.044), along with expectations/achievements mismatch (OR 1.14, 95% CI 1.03-1.26, p = 0.014) were all significantly associated with psychosis. Migration adversities (OR 1.18, 95% CI 0.672-2.06, p = 0.568) were not significantly related to the outcome. Finally, we found a dose-response effect between the number of adversities across all phases and odds of psychosis (⩾6: OR 14.09, 95% CI 2.06-96.47, p = 0.007).

CONCLUSIONS: The cumulative effect of social disadvantages before, during and after migration was associated with increased odds of psychosis in migrants, independently of ethnicity or length of stay in the country of arrival. Public health initiatives that address the social disadvantages that many migrants face during the whole migration process and post-migration psychological support may reduce the excess of psychosis in migrants.

Original language	English
Pages (from-to)	1-13
Number of pages	13
Journal	Psychological Medicine
Volume	52
Issue number	14
Early online date	10 Feb 2021
DOIs	https://doi.org/10.1017/S003329172000495X
Publication status	Published - Oct 2022

Keywords

First-episode psychosis
first-generation migrants
migration adversities
migration history
psychosis risk
social disadvantages

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Tarricone, I., D'Andrea, G., Jongsma, H. E., Tosato, S., Gayer-Anderson, C., Stilo, S. A., Suprani, F., Iyegbe, C., van der Ven, E., Quattrone, D., di Forti, M., Velthorst, E., Rossi Menezes, P., Arango, C., Parellada, M., Lasalvia, A., La Cascia, C., Ferraro, L., Bobes, J., ... Morgan, C. (2022). Migration history and risk of psychosis: results from the multinational EU-GEI study. Psychological Medicine, 52(14), 1-13. https://doi.org/10.1017/S003329172000495X

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title = "Migration history and risk of psychosis: results from the multinational EU-GEI study",

abstract = "BACKGROUND: Psychosis rates are higher among some migrant groups. We hypothesized that psychosis in migrants is associated with cumulative social disadvantage during different phases of migration.METHODS: We used data from the EUropean Network of National Schizophrenia Networks studying Gene-Environment Interactions (EU-GEI) case-control study. We defined a set of three indicators of social disadvantage for each phase: pre-migration, migration and post-migration. We examined whether social disadvantage in the pre- and post-migration phases, migration adversities, and mismatch between achievements and expectations differed between first-generation migrants with first-episode psychosis and healthy first-generation migrants, and tested whether this accounted for differences in odds of psychosis in multivariable logistic regression models.RESULTS: In total, 249 cases and 219 controls were assessed. Pre-migration (OR 1.61, 95% CI 1.06-2.44, p = 0.027) and post-migration social disadvantages (OR 1.89, 95% CI 1.02-3.51, p = 0.044), along with expectations/achievements mismatch (OR 1.14, 95% CI 1.03-1.26, p = 0.014) were all significantly associated with psychosis. Migration adversities (OR 1.18, 95% CI 0.672-2.06, p = 0.568) were not significantly related to the outcome. Finally, we found a dose-response effect between the number of adversities across all phases and odds of psychosis (⩾6: OR 14.09, 95% CI 2.06-96.47, p = 0.007).CONCLUSIONS: The cumulative effect of social disadvantages before, during and after migration was associated with increased odds of psychosis in migrants, independently of ethnicity or length of stay in the country of arrival. Public health initiatives that address the social disadvantages that many migrants face during the whole migration process and post-migration psychological support may reduce the excess of psychosis in migrants.",

keywords = "First-episode psychosis, first-generation migrants, migration adversities, migration history, psychosis risk, social disadvantages",

author = "Ilaria Tarricone and Giuseppe D'Andrea and Jongsma, {Hannah E} and Sarah Tosato and Charlotte Gayer-Anderson and Stilo, {Simona A} and Federico Suprani and Conrad Iyegbe and {van der Ven}, Els and Diego Quattrone and {di Forti}, Marta and Eva Velthorst and {Rossi Menezes}, Paulo and Celso Arango and Mara Parellada and Antonio Lasalvia and {La Cascia}, Caterina and Laura Ferraro and Julio Bobes and Miguel Bernardo and Iulio Sanju{\'a}n and Santos, {Jose Luis} and Manuel Arrojo and Del-Ben, {Cristina Marta} and Giada Tripoli and Pierre-Michel Llorca and {de Haan}, Lieuwe and Jean-Paul Selten and Andrea Tortelli and Andrei Sz{\"o}ke and Roberto Muratori and Rutten, {Bart P} and {van Os}, Jim and Jones, {Peter B} and Kirkbride, {James B} and Domenico Berardi and Murray, {Robin M} and Craig Morgan",

year = "2022",

month = oct,

doi = "https://doi.org/10.1017/S003329172000495X",

language = "English",

volume = "52",

pages = "1--13",

journal = "Psychological Medicine",

issn = "0033-2917",

publisher = "Cambridge University Press",

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Tarricone, I, D'Andrea, G, Jongsma, HE, Tosato, S, Gayer-Anderson, C, Stilo, SA, Suprani, F, Iyegbe, C, van der Ven, E, Quattrone, D, di Forti, M, Velthorst, E, Rossi Menezes, P, Arango, C, Parellada, M, Lasalvia, A, La Cascia, C, Ferraro, L, Bobes, J, Bernardo, M, Sanjuán, I, Santos, JL, Arrojo, M, Del-Ben, CM, Tripoli, G, Llorca, P-M, de Haan, L, Selten, J-P, Tortelli, A, Szöke, A, Muratori, R, Rutten, BP, van Os, J, Jones, PB, Kirkbride, JB, Berardi, D, Murray, RM & Morgan, C 2022, 'Migration history and risk of psychosis: results from the multinational EU-GEI study', Psychological Medicine, vol. 52, no. 14, pp. 1-13. https://doi.org/10.1017/S003329172000495X

TY - JOUR

T1 - Migration history and risk of psychosis

T2 - results from the multinational EU-GEI study

AU - Tarricone, Ilaria

AU - D'Andrea, Giuseppe

AU - Jongsma, Hannah E

AU - Tosato, Sarah

AU - Gayer-Anderson, Charlotte

AU - Stilo, Simona A

AU - Suprani, Federico

AU - Iyegbe, Conrad

AU - van der Ven, Els

AU - Quattrone, Diego

AU - di Forti, Marta

AU - Velthorst, Eva

AU - Rossi Menezes, Paulo

AU - Arango, Celso

AU - Parellada, Mara

AU - Lasalvia, Antonio

AU - La Cascia, Caterina

AU - Ferraro, Laura

AU - Bobes, Julio

AU - Bernardo, Miguel

AU - Sanjuán, Iulio

AU - Santos, Jose Luis

AU - Arrojo, Manuel

AU - Del-Ben, Cristina Marta

AU - Tripoli, Giada

AU - Llorca, Pierre-Michel

AU - de Haan, Lieuwe

AU - Selten, Jean-Paul

AU - Tortelli, Andrea

AU - Szöke, Andrei

AU - Muratori, Roberto

AU - Rutten, Bart P

AU - van Os, Jim

AU - Jones, Peter B

AU - Kirkbride, James B

AU - Berardi, Domenico

AU - Murray, Robin M

AU - Morgan, Craig

PY - 2022/10

Y1 - 2022/10

N2 - BACKGROUND: Psychosis rates are higher among some migrant groups. We hypothesized that psychosis in migrants is associated with cumulative social disadvantage during different phases of migration.METHODS: We used data from the EUropean Network of National Schizophrenia Networks studying Gene-Environment Interactions (EU-GEI) case-control study. We defined a set of three indicators of social disadvantage for each phase: pre-migration, migration and post-migration. We examined whether social disadvantage in the pre- and post-migration phases, migration adversities, and mismatch between achievements and expectations differed between first-generation migrants with first-episode psychosis and healthy first-generation migrants, and tested whether this accounted for differences in odds of psychosis in multivariable logistic regression models.RESULTS: In total, 249 cases and 219 controls were assessed. Pre-migration (OR 1.61, 95% CI 1.06-2.44, p = 0.027) and post-migration social disadvantages (OR 1.89, 95% CI 1.02-3.51, p = 0.044), along with expectations/achievements mismatch (OR 1.14, 95% CI 1.03-1.26, p = 0.014) were all significantly associated with psychosis. Migration adversities (OR 1.18, 95% CI 0.672-2.06, p = 0.568) were not significantly related to the outcome. Finally, we found a dose-response effect between the number of adversities across all phases and odds of psychosis (⩾6: OR 14.09, 95% CI 2.06-96.47, p = 0.007).CONCLUSIONS: The cumulative effect of social disadvantages before, during and after migration was associated with increased odds of psychosis in migrants, independently of ethnicity or length of stay in the country of arrival. Public health initiatives that address the social disadvantages that many migrants face during the whole migration process and post-migration psychological support may reduce the excess of psychosis in migrants.

AB - BACKGROUND: Psychosis rates are higher among some migrant groups. We hypothesized that psychosis in migrants is associated with cumulative social disadvantage during different phases of migration.METHODS: We used data from the EUropean Network of National Schizophrenia Networks studying Gene-Environment Interactions (EU-GEI) case-control study. We defined a set of three indicators of social disadvantage for each phase: pre-migration, migration and post-migration. We examined whether social disadvantage in the pre- and post-migration phases, migration adversities, and mismatch between achievements and expectations differed between first-generation migrants with first-episode psychosis and healthy first-generation migrants, and tested whether this accounted for differences in odds of psychosis in multivariable logistic regression models.RESULTS: In total, 249 cases and 219 controls were assessed. Pre-migration (OR 1.61, 95% CI 1.06-2.44, p = 0.027) and post-migration social disadvantages (OR 1.89, 95% CI 1.02-3.51, p = 0.044), along with expectations/achievements mismatch (OR 1.14, 95% CI 1.03-1.26, p = 0.014) were all significantly associated with psychosis. Migration adversities (OR 1.18, 95% CI 0.672-2.06, p = 0.568) were not significantly related to the outcome. Finally, we found a dose-response effect between the number of adversities across all phases and odds of psychosis (⩾6: OR 14.09, 95% CI 2.06-96.47, p = 0.007).CONCLUSIONS: The cumulative effect of social disadvantages before, during and after migration was associated with increased odds of psychosis in migrants, independently of ethnicity or length of stay in the country of arrival. Public health initiatives that address the social disadvantages that many migrants face during the whole migration process and post-migration psychological support may reduce the excess of psychosis in migrants.

KW - First-episode psychosis

KW - first-generation migrants

KW - migration adversities

KW - migration history

KW - psychosis risk

KW - social disadvantages

UR - http://www.scopus.com/inward/record.url?scp=85100781136&partnerID=8YFLogxK

U2 - https://doi.org/10.1017/S003329172000495X

DO - https://doi.org/10.1017/S003329172000495X

M3 - Article

C2 - 33563347

SN - 0033-2917

VL - 52

SP - 1

EP - 13

JO - Psychological Medicine

JF - Psychological Medicine

IS - 14

ER -

Migration history and risk of psychosis: results from the multinational EU-GEI study

Abstract

Keywords

UN SDGs

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