Mineralocorticoid receptor haplotypes sex-dependently moderate depression susceptibility following childhood maltreatment

C.H. Vinkers; M. Joels; Y. Milaneschi; L. Gerritsen; R. S. Kahn; B.W.J.H. Penninx; M.P.M. Boks

doi:https://doi.org/10.1016/j.psyneuen.2015.01.018

Mineralocorticoid receptor haplotypes sex-dependently moderate depression susceptibility following childhood maltreatment

C.H. Vinkers, M. Joels, Y. Milaneschi, L. Gerritsen, R. S. Kahn, B.W.J.H. Penninx, M.P.M. Boks

Psychiatry (VUmc)

Research output: Contribution to journal › Article › Academic › peer-review

66 Citations (Scopus)

Abstract

The MR is an important regulator of the hypothalamic-pituitary-adrenal (HPA) axis and a prime target for corticosteroids. There is increasing evidence from both clinical and preclinical studies that the MR has different effects on behavior and mood in males and females. To investigate the hypothesis that the MR sex-dependently influences the relation between childhood maltreatment and depression, we investigated three common and functional MR haplotypes (GA, CA, and CG haplotype, based on rs5522 and rs2070951) in a population-based cohort (N=665) and an independent clinical cohort from the Netherlands Study of Depression and Anxiety (NESDA) (N=1639). The CA haplotype sex-dependently moderated the relation between childhood maltreatment and depressive symptoms both in the population-based sample (sex×maltreatment×haplotype: β=-4.07, P=0.029) and in the clinical sample (sex×maltreatment×haplotype, β=-2.40, P=0.011). Specifically, female individuals in the population-based sample were protected (β=-4.58, P=2.0e

Original language	English
Pages (from-to)	90-102
Number of pages	13
Journal	Psychoneuroendocrinology
Volume	54
DOIs	https://doi.org/10.1016/j.psyneuen.2015.01.018
Publication status	Published - Apr 2015

Keywords

Adolescent
Adult
Child Abuse
Depression/genetics
Disease Susceptibility
Female
Genetic Predisposition to Disease
Haplotypes
Humans
Male
Polymorphism, Single Nucleotide
Receptors, Mineralocorticoid/genetics
Sex Factors
Young Adult

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

https://doi.org/10.1016/j.psyneuen.2015.01.018

Cite this

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title = "Mineralocorticoid receptor haplotypes sex-dependently moderate depression susceptibility following childhood maltreatment",

abstract = "The MR is an important regulator of the hypothalamic-pituitary-adrenal (HPA) axis and a prime target for corticosteroids. There is increasing evidence from both clinical and preclinical studies that the MR has different effects on behavior and mood in males and females. To investigate the hypothesis that the MR sex-dependently influences the relation between childhood maltreatment and depression, we investigated three common and functional MR haplotypes (GA, CA, and CG haplotype, based on rs5522 and rs2070951) in a population-based cohort (N=665) and an independent clinical cohort from the Netherlands Study of Depression and Anxiety (NESDA) (N=1639). The CA haplotype sex-dependently moderated the relation between childhood maltreatment and depressive symptoms both in the population-based sample (sex×maltreatment×haplotype: β=-4.07, P=0.029) and in the clinical sample (sex×maltreatment×haplotype, β=-2.40, P=0.011). Specifically, female individuals in the population-based sample were protected (β=-4.58, P=2.0e",

keywords = "Adolescent, Adult, Child Abuse, Depression/genetics, Disease Susceptibility, Female, Genetic Predisposition to Disease, Haplotypes, Humans, Male, Polymorphism, Single Nucleotide, Receptors, Mineralocorticoid/genetics, Sex Factors, Young Adult",

author = "C.H. Vinkers and M. Joels and Y. Milaneschi and L. Gerritsen and Kahn, {R. S.} and B.W.J.H. Penninx and M.P.M. Boks",

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doi = "https://doi.org/10.1016/j.psyneuen.2015.01.018",

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T1 - Mineralocorticoid receptor haplotypes sex-dependently moderate depression susceptibility following childhood maltreatment

AU - Vinkers, C.H.

AU - Joels, M.

AU - Milaneschi, Y.

AU - Gerritsen, L.

AU - Kahn, R. S.

AU - Penninx, B.W.J.H.

AU - Boks, M.P.M.

PY - 2015/4

Y1 - 2015/4

N2 - The MR is an important regulator of the hypothalamic-pituitary-adrenal (HPA) axis and a prime target for corticosteroids. There is increasing evidence from both clinical and preclinical studies that the MR has different effects on behavior and mood in males and females. To investigate the hypothesis that the MR sex-dependently influences the relation between childhood maltreatment and depression, we investigated three common and functional MR haplotypes (GA, CA, and CG haplotype, based on rs5522 and rs2070951) in a population-based cohort (N=665) and an independent clinical cohort from the Netherlands Study of Depression and Anxiety (NESDA) (N=1639). The CA haplotype sex-dependently moderated the relation between childhood maltreatment and depressive symptoms both in the population-based sample (sex×maltreatment×haplotype: β=-4.07, P=0.029) and in the clinical sample (sex×maltreatment×haplotype, β=-2.40, P=0.011). Specifically, female individuals in the population-based sample were protected (β=-4.58, P=2.0e

AB - The MR is an important regulator of the hypothalamic-pituitary-adrenal (HPA) axis and a prime target for corticosteroids. There is increasing evidence from both clinical and preclinical studies that the MR has different effects on behavior and mood in males and females. To investigate the hypothesis that the MR sex-dependently influences the relation between childhood maltreatment and depression, we investigated three common and functional MR haplotypes (GA, CA, and CG haplotype, based on rs5522 and rs2070951) in a population-based cohort (N=665) and an independent clinical cohort from the Netherlands Study of Depression and Anxiety (NESDA) (N=1639). The CA haplotype sex-dependently moderated the relation between childhood maltreatment and depressive symptoms both in the population-based sample (sex×maltreatment×haplotype: β=-4.07, P=0.029) and in the clinical sample (sex×maltreatment×haplotype, β=-2.40, P=0.011). Specifically, female individuals in the population-based sample were protected (β=-4.58, P=2.0e

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KW - Disease Susceptibility

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KW - Genetic Predisposition to Disease

KW - Haplotypes

KW - Humans

KW - Male

KW - Polymorphism, Single Nucleotide

KW - Receptors, Mineralocorticoid/genetics

KW - Sex Factors

KW - Young Adult

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