Minimally invasive approach compared to resternotomy for mitral valve surgery in patients with prior cardiac surgery: retrospective multicentre study based on the Netherlands Heart Registration

Jules R. Olsthoorn, Samuel Heuts, Saskia Houterman, Jos G. Maessen, Peyman Sardari Nia, S. Bramer, W. J. P. van Boven, A. B. A. Vonk, B. M. J. A. Koene, J. A. Bekkers, G. J. F. Hoohenkerk, A. L. P. Markou, A. de Weger, P. Segers, F. Porta, R. G. H. Speekenbrink, W. Stooker, W. W. L. Li, E. J. Daeter, N. P. van der KaaijY. Douglas

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OBJECTIVES: Mitral valve (MV) surgery after prior cardiac surgery is conventionally performed through resternotomy and associated with increased morbidity and mortality. Alternatively, MV can be approached minimally invasively [minimally invasive mitral valve surgery (MIMVS)], but longer-term follow-up of this approach for MV surgery after prior cardiac surgery is lacking. Therefore, the aim of the current study is to evaluate short- and mid-term outcomes of MIMVS versus MV surgery through resternotomy in patients with prior sternotomy, using a nationwide registry. METHODS: Patients undergoing isolated MV surgery after prior cardiac surgery between 2013 and 2018 were included. Primary outcomes were short-term morbidity and mortality and mid-term survival. Cox proportional hazard analysis was used to investigate the association between surgical approach and mortality. Propensity score matching was used to correct for potential confounders. RESULTS: In total, 290 patients underwent MV surgery after prior cardiac surgery, of whom 205 patients were operated through resternotomy and 85 patients through MIMVS. No significant differences in 30-day mortality (3.4% vs 2%, P = 0.99) were observed between both groups. Five-year survival was 86.3% in the resternotomy group, compared to 89.4% in the MIMVS group (log-rank P = 0.45). In the multivariable analysis, surgical approach showed no relation with mid-term mortality [hazard ratio 0.73 (0.34-1.60); P = 0.44]. A lower incidence of prolonged intubation and new-onset arrhythmia was observed in MIMVS. CONCLUSIONS: MV surgery after prior cardiac surgery has excellent short- and mid-term results in the Netherlands, and MIMVS and resternotomy appear to be equally efficacious. MIMVS is associated with a lower incidence of new-onset arrhythmia and prolonged intubation.
Original languageEnglish
Article numberezac420
JournalEuropean journal of cardio-thoracic surgery
Issue number5
Publication statusPublished - 1 Nov 2022


  • Minimally invasive mitral valve surgery
  • Mitral valve surgery
  • Nationwide registry
  • Reoperation
  • Resternotomy

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