TY - JOUR
T1 - Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis
AU - Osuchowski, Marcin F.
AU - Ayala, Alfred
AU - Bahrami, Soheyl
AU - Bauer, Michael
AU - Boros, Mihaly
AU - Cavaillon, Jean-Marc
AU - Chaudry, Irshad H.
AU - Coopersmith, Craig M.
AU - Deutschman, Clifford S.
AU - Drechsler, Susanne
AU - Efron, Philip
AU - Frostell, Claes
AU - Fritsch, Gerhard
AU - Gozdzik, Waldemar
AU - Hellman, Judith
AU - Huber-Lang, Markus
AU - Inoue, Shigeaki
AU - Knapp, Sylvia
AU - Kozlov, Andrey V.
AU - Libert, Claude
AU - Marshall, John C.
AU - Moldawer, Lyle L.
AU - Radermacher, Peter
AU - Redl, Heinz
AU - Remick, Daniel G.
AU - Singer, Mervyn
AU - Thiemermann, Christoph
AU - Wang, Ping
AU - Wiersinga, W. Joost
AU - Xiao, Xianzhong
AU - Zingarelli, Basilia
PY - 2018
Y1 - 2018
N2 - Preclinical animal studies precede the majority of clinical trials. While the clinical definitions of sepsis and recommended treatments are regularly updated, a systematic review of preclinical models of sepsis has not been done and clear modeling guidelines are lacking. To address this deficit, a Wiggers-Bernard Conference on preclinical sepsis modeling was held in Vienna in May, 2017. The goal of the conference was to identify limitations of preclinical sepsis models and to propose a set of guidelines, defined as the "Minimum Quality Threshold in Preclinical Sepsis Studies" (MQTiPSS), to enhance translational value of these models. A total of 31 experts from 13 countries participated and were divided into six thematic Working Groups: Study Design, Humane modeling, Infection types, Organ failure/dysfunction, Fluid resuscitation, and Antimicrobial therapy endpoints. As basis for the MQTiPSS discussions, the participants conducted a literature review of the 260 most highly cited scientific articles on sepsis models (2002-2013). Overall, the participants reached consensus on 29 points; 20 at "recommendation" and nine at "consideration" strength. This Executive Summary provides a synopsis of the MQTiPSS consensus. We believe that these recommendations and considerations will serve to bring a level of standardization to preclinical models of sepsis and ultimately improve translation of preclinical findings. These guideline points are proposed as "best practices" for animal models of sepsis that should be implemented. To encourage its wide dissemination, this article is freely accessible on the Intensive Care Medicine Experimental and Infection journal websites. In order to encourage its wide dissemination, this article is freely accessible in Shock, Infection, and Intensive Care Medicine Experimental.
AB - Preclinical animal studies precede the majority of clinical trials. While the clinical definitions of sepsis and recommended treatments are regularly updated, a systematic review of preclinical models of sepsis has not been done and clear modeling guidelines are lacking. To address this deficit, a Wiggers-Bernard Conference on preclinical sepsis modeling was held in Vienna in May, 2017. The goal of the conference was to identify limitations of preclinical sepsis models and to propose a set of guidelines, defined as the "Minimum Quality Threshold in Preclinical Sepsis Studies" (MQTiPSS), to enhance translational value of these models. A total of 31 experts from 13 countries participated and were divided into six thematic Working Groups: Study Design, Humane modeling, Infection types, Organ failure/dysfunction, Fluid resuscitation, and Antimicrobial therapy endpoints. As basis for the MQTiPSS discussions, the participants conducted a literature review of the 260 most highly cited scientific articles on sepsis models (2002-2013). Overall, the participants reached consensus on 29 points; 20 at "recommendation" and nine at "consideration" strength. This Executive Summary provides a synopsis of the MQTiPSS consensus. We believe that these recommendations and considerations will serve to bring a level of standardization to preclinical models of sepsis and ultimately improve translation of preclinical findings. These guideline points are proposed as "best practices" for animal models of sepsis that should be implemented. To encourage its wide dissemination, this article is freely accessible on the Intensive Care Medicine Experimental and Infection journal websites. In order to encourage its wide dissemination, this article is freely accessible in Shock, Infection, and Intensive Care Medicine Experimental.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85055735150&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30106875
U2 - https://doi.org/10.1097/SHK.0000000000001212
DO - https://doi.org/10.1097/SHK.0000000000001212
M3 - Article
C2 - 30106875
SN - 1073-2322
VL - 50
SP - 377
EP - 380
JO - Shock (Augusta, Ga.)
JF - Shock (Augusta, Ga.)
IS - 4
ER -