Mitochondrial fission: firing up mitochondria in brown adipose tissue

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    Abstract

    Brown adipose tissue (BAT) is an important site for energy expenditure, for instance to generate heat in times of cold exposure. BAT expansion and activation can increase energy dissipation of an organism. This involves the coordinated activation of mitochondrial metabolism and heat generation through uncoupling of oxidative phosphorylation. In this issue of The EMBO Journal, the Shirihai group uncovers a novel potentiation pathway for BAT energy expenditure. Changes in mitochondrial dynamics, in particular mitochondrial fission, act in synergy with fatty acid-induced uncoupling to activate BAT metabolism in response to the hormone norepinephrine
    Original languageEnglish
    Pages (from-to)401-402
    JournalEMBO Journal
    Volume33
    Issue number5
    DOIs
    Publication statusPublished - 2014

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