Modelling the leptomeningeal collateral circulation during acute ischaemic stroke

Raymond M. Padmos; Nerea Arrarte Terreros; Tamás I. Józsa; Gábor Závodszky; Henk A. Marquering; Charles B.L.M. Majoie; Alfons G. Hoekstra

doi:https://doi.org/10.1016/j.medengphy.2021.03.003

Modelling the leptomeningeal collateral circulation during acute ischaemic stroke

Raymond M. Padmos, Nerea Arrarte Terreros, Tamás I. Józsa, Gábor Závodszky, Henk A. Marquering, Charles B.L.M. Majoie, Alfons G. Hoekstra

Research output: Contribution to journal › Article › Academic › peer-review

9 Citations (Scopus)

Abstract

A novel model of the leptomeningeal collateral circulation is created by combining data from multiple sources with statistical scaling laws. The extent of the collateral circulation is varied by defining a collateral vessel probability. Blood flow and pressure are simulated using a one-dimensional steady state blood flow model. The leptomeningeal collateral vessels provide significant flow during a stroke. The pressure drop over an occlusion predicted by the model ranges between 60 and 85 mmHg depending on the extent of the collateral circulation. The linear transport of contrast material was simulated in the circulatory network. The time delay of peak contrast over an occlusion is 3.3 s in the model, and 2.1 s (IQR 0.8–4.0 s) when measured in dynamic CTA data of acute ischaemic stroke patients. Modelling the leptomeningeal collateral circulation could lead to better estimates of infarct volume and patient outcome.

Original language	English
Pages (from-to)	1-11
Number of pages	11
Journal	Medical Engineering and Physics
Volume	91
Early online date	17 Mar 2021
DOIs	https://doi.org/10.1016/j.medengphy.2021.03.003
Publication status	Published - 1 May 2021

Keywords

1D blood flow model
Acute ischaemic stroke
Cerebral contrast transport
Collateral flow simulation
Leptomeningeal collateral circulation

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title = "Modelling the leptomeningeal collateral circulation during acute ischaemic stroke",

abstract = "A novel model of the leptomeningeal collateral circulation is created by combining data from multiple sources with statistical scaling laws. The extent of the collateral circulation is varied by defining a collateral vessel probability. Blood flow and pressure are simulated using a one-dimensional steady state blood flow model. The leptomeningeal collateral vessels provide significant flow during a stroke. The pressure drop over an occlusion predicted by the model ranges between 60 and 85 mmHg depending on the extent of the collateral circulation. The linear transport of contrast material was simulated in the circulatory network. The time delay of peak contrast over an occlusion is 3.3 s in the model, and 2.1 s (IQR 0.8–4.0 s) when measured in dynamic CTA data of acute ischaemic stroke patients. Modelling the leptomeningeal collateral circulation could lead to better estimates of infarct volume and patient outcome.",

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AU - Marquering, Henk A.

AU - Majoie, Charles B.L.M.

AU - Hoekstra, Alfons G.

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N2 - A novel model of the leptomeningeal collateral circulation is created by combining data from multiple sources with statistical scaling laws. The extent of the collateral circulation is varied by defining a collateral vessel probability. Blood flow and pressure are simulated using a one-dimensional steady state blood flow model. The leptomeningeal collateral vessels provide significant flow during a stroke. The pressure drop over an occlusion predicted by the model ranges between 60 and 85 mmHg depending on the extent of the collateral circulation. The linear transport of contrast material was simulated in the circulatory network. The time delay of peak contrast over an occlusion is 3.3 s in the model, and 2.1 s (IQR 0.8–4.0 s) when measured in dynamic CTA data of acute ischaemic stroke patients. Modelling the leptomeningeal collateral circulation could lead to better estimates of infarct volume and patient outcome.

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Modelling the leptomeningeal collateral circulation during acute ischaemic stroke

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Keywords

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