Moderate alcohol consumption and lipoprotein-associated phospholipase A2 activity

Joline W.J. Beulens, Robin van den Berg, Frans J. Kok, Anders Helander, Susan H.F. Vermunt, Henk F.J. Hendriks

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Background and aims: To investigate the effect of moderate alcohol consumption on lipoprotein-associated phospholipase A2 activity, markers of inflammation and oxidative stress and whether these effects are modified by BMI. Methods and results: Eleven lean (BMI: 18.5-25 kg/m2) and 9 overweight (BMI > 27 kg/m2) men participated in a randomized controlled crossover trial. After consuming 3 cans of beer (40 g ethanol) or alcohol-free beer daily during 3 weeks, fasting blood samples were taken. HDL cholesterol increased by 18.2% (p < 0.001) after beer compared to alcohol-free beer, while LDL cholesterol decreased by 7.8% (p = 0.008). Lipoprotein-associated phospholipase A2 activity was not different (p = 0.23) between beer (47.5 ± 0.8) and alcohol-free beer (48.9 ± 0.8). High-sensitive C-reactive protein was unaffected, but urinary isoprostanes tended to increase (p = 0.09) after beer (114.0 ± 6.9) compared to alcohol-free beer (96.9 ± 6.5). An interaction between BMI and treatment (p < 0.05) on liver enzymes was observed, indicating an increase of liver enzymes after moderate alcohol consumption in overweight men only. Conclusion: Despite profound effects on HDL and LDL cholesterol, moderate alcohol consumption did not affect lipoprotein-associated phospholipase A2 activity. Liver enzymes increased after alcohol consumption in overweight men only, suggesting a less favorable response to moderate alcohol consumption in overweight people.

Original languageEnglish
Pages (from-to)539-544
Number of pages6
JournalNutrition, Metabolism and Cardiovascular Diseases
Issue number8
Publication statusPublished - 1 Oct 2008


  • F2-isoprostanes
  • Lipoprotein-associated phospholipase A2
  • Liver enzymes
  • Moderate alcohol consumption
  • Obesity

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