TY - JOUR
T1 - Molecular characterization of colorectal cancer related peritoneal metastatic disease
AU - Lenos, Kristiaan J.
AU - Bach, Sander
AU - Ferreira Moreno, Leandro
AU - ten Hoorn, Sanne
AU - Sluiter, Nina R.
AU - Bootsma, Sanne
AU - Vieira Braga, Felipe A.
AU - Nijman, Lisanne E.
AU - van den Bosch, Tom
AU - Miedema, Daniel M.
AU - van Dijk, Erik
AU - Ylstra, Bauke
AU - Kulicke, Ruth
AU - Davis, Fred P.
AU - Stransky, Nicolas
AU - Smolen, Gromoslaw A.
AU - Coebergh van den Braak, Robert R. J.
AU - IJzermans, Jan N. M.
AU - Martens, John W. M.
AU - Hallam, Sally
AU - Beggs, Andrew D.
AU - Kops, Geert J. P. L.
AU - Lansu, Nico
AU - Bastiaenen, Vivian P.
AU - Klaver, Charlotte E. L.
AU - Lecca, Maria C.
AU - el Makrini, Khalid
AU - Elbers, Clara C.
AU - Dings, Mark P. G.
AU - van Noesel, Carel J. M.
AU - Kranenburg, Onno
AU - Medema, Jan Paul
AU - Koster, Jan
AU - Koens, Lianne
AU - Punt, Cornelis J. A.
AU - Tanis, Pieter J.
AU - de Hingh, Ignace H.
AU - Bijlsma, Maarten F.
AU - Tuynman, Jurriaan B.
AU - Vermeulen, Louis
N1 - Funding Information: This work is supported by Oncode Institute, The New York Stem Cell Foundation, grants from KWF (10529 to L.V. and 13435 to M.F.B.), the European Research Council (ERC-StG 638193) and ZonMw (Vidi 016.156.308) to L.V. L.V. is a New York Stem Cell Foundation – Robertson Investigator. Publisher Copyright: © 2022, The Author(s).
PY - 2022/12/1
Y1 - 2022/12/1
N2 - A significant proportion of colorectal cancer (CRC) patients develop peritoneal metastases (PM) in the course of their disease. PMs are associated with a poor quality of life, significant morbidity and dismal disease outcome. To improve care for this patient group, a better understanding of the molecular characteristics of CRC-PM is required. Here we present a comprehensive molecular characterization of a cohort of 52 patients. This reveals that CRC-PM represent a distinct CRC molecular subtype, CMS4, but can be further divided in three separate categories, each presenting with unique features. We uncover that the CMS4-associated structural protein Moesin plays a key role in peritoneal dissemination. Finally, we define specific evolutionary features of CRC-PM which indicate that polyclonal metastatic seeding underlies these lesions. Together our results suggest that CRC-PM should be perceived as a distinct disease entity.
AB - A significant proportion of colorectal cancer (CRC) patients develop peritoneal metastases (PM) in the course of their disease. PMs are associated with a poor quality of life, significant morbidity and dismal disease outcome. To improve care for this patient group, a better understanding of the molecular characteristics of CRC-PM is required. Here we present a comprehensive molecular characterization of a cohort of 52 patients. This reveals that CRC-PM represent a distinct CRC molecular subtype, CMS4, but can be further divided in three separate categories, each presenting with unique features. We uncover that the CMS4-associated structural protein Moesin plays a key role in peritoneal dissemination. Finally, we define specific evolutionary features of CRC-PM which indicate that polyclonal metastatic seeding underlies these lesions. Together our results suggest that CRC-PM should be perceived as a distinct disease entity.
UR - http://www.scopus.com/inward/record.url?scp=85135431694&partnerID=8YFLogxK
U2 - https://doi.org/10.1038/s41467-022-32198-z
DO - https://doi.org/10.1038/s41467-022-32198-z
M3 - Article
C2 - 35927254
SN - 2041-1723
VL - 13
JO - Nature communications
JF - Nature communications
IS - 1
M1 - 4443
ER -