TY - JOUR
T1 - Molecular regulation of the hepatic bile acid uptake transporter and HBV entry receptor NTCP
AU - Appelman, Monique D.
AU - Wettengel, Jochen M.
AU - Protzer, Ulrike
AU - Oude Elferink, Ronald P. J.
AU - van de Graaf, Stan F. J.
N1 - Funding Information: SFJvdG is supported by the Amsterdam University Medical Centers (AGEM innovation grant). UP is supported by the German Research Foundation (DFG) TRR179 , TP14 . ROE is supported by the Dutch Cancer Foundation (KWF; Unique High risk project # 11652 ), by the Dioraphte Foundation and by the Amsterdam University Medical Centers (AUMC, PhD Scholarships). We thank Imogen Morris for help with revising the English language of this manuscript. Publisher Copyright: © 2021 The Author(s)
PY - 2021/8/1
Y1 - 2021/8/1
N2 - Transporters expressed by hepatocytes and enterocytes play a critical role in maintaining the enterohepatic circulation of bile acids. The sodium taurocholate cotransporting polypeptide (NTCP), exclusively expressed at the basolateral side of hepatocytes, mediates the uptake of conjugated bile acids. In conditions where bile flow is impaired (cholestasis), pharmacological inhibition of NTCP-mediated bile acid influx is suggested to reduce hepatocellular damage due to bile acid overload. Furthermore, NTCP has been shown to play an important role in hepatitis B virus (HBV) and hepatitis Delta virus (HDV) infection by functioning as receptor for viral entry into hepatocytes. This review provides a summary of current molecular insight into the regulation of NTCP expression at the plasma membrane, hepatic bile acid transport, and NTCP-mediated viral infection.
AB - Transporters expressed by hepatocytes and enterocytes play a critical role in maintaining the enterohepatic circulation of bile acids. The sodium taurocholate cotransporting polypeptide (NTCP), exclusively expressed at the basolateral side of hepatocytes, mediates the uptake of conjugated bile acids. In conditions where bile flow is impaired (cholestasis), pharmacological inhibition of NTCP-mediated bile acid influx is suggested to reduce hepatocellular damage due to bile acid overload. Furthermore, NTCP has been shown to play an important role in hepatitis B virus (HBV) and hepatitis Delta virus (HDV) infection by functioning as receptor for viral entry into hepatocytes. This review provides a summary of current molecular insight into the regulation of NTCP expression at the plasma membrane, hepatic bile acid transport, and NTCP-mediated viral infection.
KW - ASBT
KW - BSEP
KW - Cholestasis
KW - HBV
KW - HDV
UR - http://www.scopus.com/inward/record.url?scp=85105361214&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.bbalip.2021.158960
DO - https://doi.org/10.1016/j.bbalip.2021.158960
M3 - Review article
C2 - 33932583
SN - 1388-1981
VL - 1866
JO - BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
JF - BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
IS - 8
M1 - 158960
ER -