Molecular typing of human platelet and neutrophil antigens (HPA and HNA)

Barbera Veldhuisen, Leendert Porcelijn, C. Ellen van der Schoot, Masja de Haas

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Genotyping is an important tool in the diagnosis of disorders involving allo-immunisation to antigens present on the membranes of platelets and neutrophils. To date 28 human platelet antigens (HPAs) have been indentified on six polymorphic glycoproteins on the surface of platelets. Antibodies against HPAs play a role in foetal and neonatal alloimmune thrombocytopenia (FNAIT), post-transfusion purpura (PTP) and refractoriness to donor platelets. The 11 human neutrophil antigens (HNAs) described to date have been indentified on five polymorphic proteins on the surface of granulocytes. Antibodies to HNAs are implicated with foetal and neonatal alloimmune neutropenia (FNAIN), autoimmune neutropenia (AIN) and transfusion related acute lung injury (TRALI). In this report, we will review the molecular basis and techniques currently available for the genotyping of human platelet and neutrophil antigens
Original languageEnglish
Pages (from-to)189-199
JournalTransfusion and apheresis science : official journal of the World Apheresis Association
Volume50
Issue number2
DOIs
Publication statusPublished - 2014

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