TY - JOUR
T1 - Monitoring local delivery of vancomycin from gelatin nanospheres in zebrafish larvae
AU - Zhang, Xiaolin
AU - Song, Jiankang
AU - Klymov, Alexey
AU - Zhang, Yang
AU - de Boer, Leonie
AU - Jansen, John A.
AU - van den Beucken, Jeroen Jjp
AU - Yang, Fang
AU - Zaat, Sebastian Aj
AU - Leeuwenburgh, Sander Cg
PY - 2018
Y1 - 2018
N2 - Background: Infections such as biomaterial-associated infection and osteomyelitis are often associated with intracellular survival of bacteria (eg, Staphylococcus aureus). Treatment of these infections remains a major challenge due to the low intracellular efficacy of many antibiotics. Therefore, local delivery systems are urgently required to improve the therapeutic efficacy of antibiotics by enabling their intracellular delivery.
AB - Background: Infections such as biomaterial-associated infection and osteomyelitis are often associated with intracellular survival of bacteria (eg, Staphylococcus aureus). Treatment of these infections remains a major challenge due to the low intracellular efficacy of many antibiotics. Therefore, local delivery systems are urgently required to improve the therapeutic efficacy of antibiotics by enabling their intracellular delivery.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85055637372&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30254441
U2 - https://doi.org/10.2147/IJN.S168959
DO - https://doi.org/10.2147/IJN.S168959
M3 - Article
C2 - 30254441
SN - 1176-9114
VL - 13
SP - 5377
EP - 5394
JO - International journal of nanomedicine
JF - International journal of nanomedicine
ER -