Monitoring local delivery of vancomycin from gelatin nanospheres in zebrafish larvae

Xiaolin Zhang, Jiankang Song, Alexey Klymov, Yang Zhang, Leonie de Boer, John A. Jansen, Jeroen Jjp van den Beucken, Fang Yang, Sebastian Aj Zaat, Sander Cg Leeuwenburgh

Research output: Contribution to JournalArticleAcademicpeer-review

9 Citations (Scopus)

Abstract

Background: Infections such as biomaterial-associated infection and osteomyelitis are often associated with intracellular survival of bacteria (eg, Staphylococcus aureus). Treatment of these infections remains a major challenge due to the low intracellular efficacy of many antibiotics. Therefore, local delivery systems are urgently required to improve the therapeutic efficacy of antibiotics by enabling their intracellular delivery.
Original languageEnglish
Pages (from-to)5377-5394
JournalInternational journal of nanomedicine
Volume13
DOIs
Publication statusPublished - 2018

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