Morphological transformation by early region human polyomavirus BK DNA of human fibroblasts with deletions in the short arm of one chromosome 11

A. de Ronde; M. Mannens; R. M. Slater; J. Hoovers; C. Heyting; E. M. Bleeker-Wagemakers; N. J. Leschot; A. van Strien; C. J. Sol; J. ter Schegget

doi:https://doi.org/10.1099/0022-1317-69-2-467

Morphological transformation by early region human polyomavirus BK DNA of human fibroblasts with deletions in the short arm of one chromosome 11

A. de Ronde, M. Mannens, R. M. Slater, J. Hoovers, C. Heyting, E. M. Bleeker-Wagemakers, N. J. Leschot, A. van Strien, C. J. Sol, J. ter Schegget

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Abstract

Human fibroblasts derived from four individuals with various deletions in the short arm of one chromosome 11 were susceptible to morphological transformation by early region BK virus DNA, whereas diploid human fibroblasts were not. This difference in susceptibility to transformation by early region BK virus DNA might be explained by a putative 'transformation suppressor' locus situated within the deleted region on the short arm of chromosome 11

Original language	English
Pages (from-to)	467-471
Journal	Journal of general virology
Volume	69
Issue number	2
DOIs	https://doi.org/10.1099/0022-1317-69-2-467
Publication status	Published - 1988

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https://doi.org/10.1099/0022-1317-69-2-467

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de Ronde, A., Mannens, M., Slater, R. M., Hoovers, J., Heyting, C., Bleeker-Wagemakers, E. M., Leschot, N. J., van Strien, A., Sol, C. J., & ter Schegget, J. (1988). Morphological transformation by early region human polyomavirus BK DNA of human fibroblasts with deletions in the short arm of one chromosome 11. Journal of general virology, 69(2), 467-471. https://doi.org/10.1099/0022-1317-69-2-467

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abstract = "Human fibroblasts derived from four individuals with various deletions in the short arm of one chromosome 11 were susceptible to morphological transformation by early region BK virus DNA, whereas diploid human fibroblasts were not. This difference in susceptibility to transformation by early region BK virus DNA might be explained by a putative 'transformation suppressor' locus situated within the deleted region on the short arm of chromosome 11",

author = "{de Ronde}, A. and M. Mannens and Slater, {R. M.} and J. Hoovers and C. Heyting and Bleeker-Wagemakers, {E. M.} and Leschot, {N. J.} and {van Strien}, A. and Sol, {C. J.} and {ter Schegget}, J.",

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de Ronde, A, Mannens, M, Slater, RM, Hoovers, J, Heyting, C, Bleeker-Wagemakers, EM, Leschot, NJ, van Strien, A, Sol, CJ & ter Schegget, J 1988, 'Morphological transformation by early region human polyomavirus BK DNA of human fibroblasts with deletions in the short arm of one chromosome 11', Journal of general virology, vol. 69, no. 2, pp. 467-471. https://doi.org/10.1099/0022-1317-69-2-467

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T1 - Morphological transformation by early region human polyomavirus BK DNA of human fibroblasts with deletions in the short arm of one chromosome 11

AU - de Ronde, A.

AU - Mannens, M.

AU - Slater, R. M.

AU - Hoovers, J.

AU - Heyting, C.

AU - Bleeker-Wagemakers, E. M.

AU - Leschot, N. J.

AU - van Strien, A.

AU - Sol, C. J.

AU - ter Schegget, J.

PY - 1988

Y1 - 1988

N2 - Human fibroblasts derived from four individuals with various deletions in the short arm of one chromosome 11 were susceptible to morphological transformation by early region BK virus DNA, whereas diploid human fibroblasts were not. This difference in susceptibility to transformation by early region BK virus DNA might be explained by a putative 'transformation suppressor' locus situated within the deleted region on the short arm of chromosome 11

AB - Human fibroblasts derived from four individuals with various deletions in the short arm of one chromosome 11 were susceptible to morphological transformation by early region BK virus DNA, whereas diploid human fibroblasts were not. This difference in susceptibility to transformation by early region BK virus DNA might be explained by a putative 'transformation suppressor' locus situated within the deleted region on the short arm of chromosome 11

U2 - https://doi.org/10.1099/0022-1317-69-2-467

DO - https://doi.org/10.1099/0022-1317-69-2-467

M3 - Article

C2 - 2828520

SN - 0022-1317

VL - 69

SP - 467

EP - 471

JO - Journal of general virology

JF - Journal of general virology

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