TY - JOUR
T1 - Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation
AU - van Gisbergen, Klaas P. J. M.
AU - Kragten, Natasja A. M.
AU - Hertoghs, Kirsten M. L.
AU - Wensveen, Felix M.
AU - Jonjic, Stipan
AU - Hamann, Jörg
AU - Nolte, Martijn A.
AU - van Lier, Rene A. W.
PY - 2012
Y1 - 2012
N2 - The transcriptional repressor Blimp-1 mediates the terminal differentiation of many cell types, including T cells. Here we identified Hobit (Znf683) as a previously unrecognized homolog of Blimp-1 that was specifically expressed in mouse natural killer T cells (NKT cells). Through studies of Hobit-deficient mice, we found that Hobit was essential for the formation of mature thymic NKT cells. In the periphery, Hobit repressed the accumulation of interferon-gamma (IFN-gamma)-producing NK1.1(lo) NKT cells at steady state. After antigenic stimulation, Hobit repressed IFN-gamma expression, whereas after innate stimulation, Hobit induced granzyme B expression. Thus, reminiscent of the function of Blimp-1 in other lymphocytes, Hobit controlled the maintenance of quiescent, fully differentiated NKT cells and regulated their immediate effector functions
AB - The transcriptional repressor Blimp-1 mediates the terminal differentiation of many cell types, including T cells. Here we identified Hobit (Znf683) as a previously unrecognized homolog of Blimp-1 that was specifically expressed in mouse natural killer T cells (NKT cells). Through studies of Hobit-deficient mice, we found that Hobit was essential for the formation of mature thymic NKT cells. In the periphery, Hobit repressed the accumulation of interferon-gamma (IFN-gamma)-producing NK1.1(lo) NKT cells at steady state. After antigenic stimulation, Hobit repressed IFN-gamma expression, whereas after innate stimulation, Hobit induced granzyme B expression. Thus, reminiscent of the function of Blimp-1 in other lymphocytes, Hobit controlled the maintenance of quiescent, fully differentiated NKT cells and regulated their immediate effector functions
U2 - https://doi.org/10.1038/ni.2393
DO - https://doi.org/10.1038/ni.2393
M3 - Article
C2 - 22885984
SN - 1529-2908
VL - 13
SP - 864
EP - 871
JO - Nature immunology
JF - Nature immunology
IS - 9
ER -