mRNA-based SARS-CoV-2 vaccination is associated with reduced ICU admission rate and disease severity in critically ill COVID-19 patients treated in Switzerland

the RISC-19-ICU Investigators for Switzerland

doi:https://doi.org/10.1007/s00134-021-06610-z

mRNA-based SARS-CoV-2 vaccination is associated with reduced ICU admission rate and disease severity in critically ill COVID-19 patients treated in Switzerland

the RISC-19-ICU Investigators for Switzerland

Research output: Contribution to journal › Comment/Letter to the editor › Academic

16 Citations (Scopus)

Original language	English
Pages (from-to)	362-365
Number of pages	4
Journal	Intensive care medicine
Volume	48
Issue number	3
Early online date	2022
DOIs	https://doi.org/10.1007/s00134-021-06610-z
Publication status	Published - Mar 2022

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https://doi.org/10.1007/s00134-021-06610-z

Cite this

@article{319454482b04458ca647c155c5f8aded,

title = "mRNA-based SARS-CoV-2 vaccination is associated with reduced ICU admission rate and disease severity in critically ill COVID-19 patients treated in Switzerland",

author = "Hilty, {Matthias Peter} and Stefanie Keiser and {Wendel Garcia}, {Pedro D.} and Andr{\'e} Moser and Schuepbach, {Reto A.} and {the RISC-19-ICU Investigators for Switzerland} and Hilty, {Matthias P.} and Sch{\"u}pbach, {Reto A.} and Garcia, {Pedro D. Wendel} and Thierry Fumeaux and Philippe Guerci and Jonathan Montomoli and Sch{\"u}pbach, {Reto A.} and Silvio Brugger and Jan Bartussek and Sascha David and Anne-Aylin Sigg and Annelies Zinkernagel and Mallory Moret-Bochatay and Bernd Yuen and Thomas Hillermann and Anette Ristic and Michael Sepulcri and Miodrag Filipovic and Urs Pietsch and Petra Salomon and Iris Drvaric and Peter Schott and Severin Urech and Adriana Lambert and Lukas Merki and Marcus Laube and Frank Hillgaertner and Marianne Sieber and Alexander Dullenkopf and Lina Petersen and Serge Grazioli and Rimensberger, {Peter C.} and Isabelle Fleisch and Jerome Lavanchy and Marie-Helene Perez and Katharina Marquardt and Karim Shaikh and Hermann Redecker and Michael Stephan and Jan Brem and Bjarte Rogdo and Andre Birkenmaier and {Meyer zu Bentrup}, Friederike and Patricia Fodor and Pascal Locher",

note = "Funding Information: This work is endorsed by the Swiss Society of Intensive Care Medicine. We want to thank all nurses, physicians and other healthcare workers in our collaborating centers for their tireless and brave efforts in the care of their patients, without you this health care emergency could not be overcome. We thank Stephan M. Jakob, Yok-Ai Que, Anne-Aylin Sigg, Thierry Fumeaux, Philippe Guerci, Jonathan Montomoli, and Tanja Stadler for their invaluable help with this manuscript. The members of RISC-19-ICU Investigators for Switzerland: RISC-19-ICU Board (Matthias P. Hilty, MD; Reto A. Sch{\"u}pbach, MD; Pedro D. Wendel Garcia, MSc; Thierry Fumeaux, MD; Philippe Guerci, MD Ph.D.; Jonathan Montomoli, MD Ph.D.); Institute of Intensive Care Medicine, University Hospital Zurich, Zurich (Reto A. Sch{\"u}pbach MD; Silvio Brugger, MD, Ph.D.; Jan Bartussek, Ph.D.; Sascha David, MD; Stefanie Keiser, Ph.D.; Anne-Aylin Sigg; Annelies Zinkernagel, MD, Ph.D.); Soins intensifs, Groupement Hospitalier de l'Ouest L{\'e}manique—Hopital de Nyon, Nyon (Mallory Moret-Bochatay, MD); Interdisziplinaere Intensivstation, Spital Buelach, Buelach (Bernd Yuen, MD; Thomas Hillermann, MD); Department for Intensive Care Medicine, Kantonsspital Nidwalden, Stans (Anette Ristic, MD; Michael Sepulcri, MD); Department of Anesthesiology and Intensive Care Medicine, Cantonal Hospital St. Gallen, St. Gallen (Miodrag Filipovic, MD; Urs Pietsch, MD); Intensivstation, Regionalspital Emmental AG, Burgdorf (Petra Salomon, MD; Iris Drvaric, MD); Institut fuer Anesthaesie und Intensivmedizin, Zuger Kantonsspital AG, Baar (Peter Schott, MD; Severin Urech, MD); Intensivmedizin, St. Claraspital, Basel (Adriana Lambert, MD; Lukas Merki, MD); Department Intensive Care Medicine, Spitalzentrum Biel, Biel (Marcus Laube, MD); Intensivmedizin, Kantonsspital Graub{\"u}nden, Chur (Frank Hillgaertner, MD; Marianne Sieber); Institut fuer Anaesthesie und Intensivmedizin, Spital Thurgau, Frauenfeld (Alexander Dullenkopf, MD; Lina Petersen, MD); Division of Neonatal and Pediatric Intensive Care, Geneva University Hospitals, Geneva (Serge Grazioli, MD; Peter C. Rimensberger, MD); Soins Intensifs, Hirslanden Clinique Cecil, Lausanne (Isabelle Fleisch, MD; Jerome Lavanchy, MD); Pediatric Intensive Care Unit, University Hospital Lausanne, Lausanne (Marie-Helene Perez, MD); Interdisziplinaere Intensivstation, Spital Maennedorf AG, Maennedorf (Katharina Marquardt, MD; Karim Shaikh, MD); Intensivmedizin, Schweizer Paraplegikerzentrum Nottwil, Nottwil (Hermann Redecker, MD); Intensivmedizin, Spital Oberengadin, Samedan (Michael Stephan, MD; Jan Brem, MD); Paediatric Intensive Care Unit, Children{\textquoteright}s Hospital of Eastern Switzerland, St. Gallen (Bjarte Rogdo, MD; Andre Birkenmaier, MD); Klinik f{\"u}r Anaesthesie und Intensivmedizin, Spitalzentrum Oberwallis, Visp (Friederike Meyer zu Bentrup, MD, MBA); Interdisziplinaere Intensivstation, Stadtspital Triemli, Zurich (Patricia Fodor, MD; Pascal Locher, MD); Department Intensivmedizin, Universitaetsspital Basel, Basel (Martin Siegemund, MD; Nuria Zellweger); Department of Intensive Care Medicine, University Hospital Bern—Inselspital, Bern (Stephan M Jakob, MD; Yok-Ai Que, MD Ph.D.; Marie-Madlen Jeitziner, RN, Ph.D.; Beatrice Jenni-Moser, RN, MSc); Interdisziplinaere Intensivmedizin, Lindenhofspital, Bern, Switzerland (Jan Wiegand, MD); Intensivstation, Spital Grabs, Grabs (Christian B{\"u}rkle, MD); Medical ICU, Cantonal Hospital St.Gallen, St. Gallen (Gian-Reto Kleger, MD); Service d'Anesthesiologie, EHNV, Yverdon-les-Bains (Marilene Franchitti Laurent, MD; Jean-Christophe Laurent, MD); Abteilung f{\"u}r Anaesthesiologie und Intensivmedizin, Hirslanden Klinik Im Park, Z{\"u}rich (Tomislav Gaspert, MD; Marija Jovic, MD); Intensivmedizin & Intermediate Care, Kantonsspital Olten, Olten (Michael Studhalter, MD); Institut f{\"u}r Anaesthesiologie und Intensivmedizin, Klinik Hirslanden, Zurich (Christoph Haberthuer, MD; Roger F. Lussman, MD); Anaesthesie Intensivmedizin Schmerzmedizin, Spital Schwyz, Schwyz (Daniela Selz, MD; Didier Naon, MD); Dipartimento Area Critica, Clinica Luganese Moncucco, Lugano (Andrea Glotta, MD; Samuele Ceruti, MD); Institut f{\"u}r Anaesthesiologie Intensivmedizin & Rettungsmedizin, See-Spital Horgen & Kilchberg, Horgen (Julien Marrel, MD; Mirko Brenni, MD); Klinik f{\"u}r Operative Intensivmedizin, Kantonsspital Aarau, Aarau (Rolf Ensner, MD; Marc Michot, MD); Intensivstation, Kantonsspital Schaffhausen, Schaffhausen (Nadine Gehring, MD); Intensivstation, Spital Simmental-Thun-Saanenland AG, Thun (Antje Heise, MD); Klinik f{\"u}r Anaesthesie Intensivmedizin Operationszentrum und Schmerzmedizin, Kantonsspital Muensterlingen, Muensterlingen (Tobias Huebner, MD; Thomas A. Neff, MD); Division of Intensive Care, University Hospitals of Geneva, Geneva (Sara Cereghetti, MD; Filippo Boroli, MD; Jerome Pugin, MD, Ph.D.). Funding Information: This work is funded and endorsed by the Swiss Society of Intensive Care Medicine and unrestricted research grants by the Institute of Intensive Care Medicine at the University Hospital of Zurich, CytoSorbents Europe GmbH, Berlin, Germany, and Union Bancaire Priv{\'e}e, Geneva, Switzerland. The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.",

year = "2022",

month = mar,

doi = "https://doi.org/10.1007/s00134-021-06610-z",

language = "English",

volume = "48",

pages = "362--365",

journal = "Intensive care medicine",

issn = "0342-4642",

publisher = "Springer Verlag",

number = "3",

}

TY - JOUR

T1 - mRNA-based SARS-CoV-2 vaccination is associated with reduced ICU admission rate and disease severity in critically ill COVID-19 patients treated in Switzerland

AU - Hilty, Matthias Peter

AU - Keiser, Stefanie

AU - Wendel Garcia, Pedro D.

AU - Moser, André

AU - Schuepbach, Reto A.

AU - the RISC-19-ICU Investigators for Switzerland

AU - Hilty, Matthias P.

AU - Schüpbach, Reto A.

AU - Garcia, Pedro D. Wendel

AU - Fumeaux, Thierry

AU - Guerci, Philippe

AU - Montomoli, Jonathan

AU - Schüpbach, Reto A.

AU - Brugger, Silvio

AU - Bartussek, Jan

AU - David, Sascha

AU - Sigg, Anne-Aylin

AU - Zinkernagel, Annelies

AU - Moret-Bochatay, Mallory

AU - Yuen, Bernd

AU - Hillermann, Thomas

AU - Ristic, Anette

AU - Sepulcri, Michael

AU - Filipovic, Miodrag

AU - Pietsch, Urs

AU - Salomon, Petra

AU - Drvaric, Iris

AU - Schott, Peter

AU - Urech, Severin

AU - Lambert, Adriana

AU - Merki, Lukas

AU - Laube, Marcus

AU - Hillgaertner, Frank

AU - Sieber, Marianne

AU - Dullenkopf, Alexander

AU - Petersen, Lina

AU - Grazioli, Serge

AU - Rimensberger, Peter C.

AU - Fleisch, Isabelle

AU - Lavanchy, Jerome

AU - Perez, Marie-Helene

AU - Marquardt, Katharina

AU - Shaikh, Karim

AU - Redecker, Hermann

AU - Stephan, Michael

AU - Brem, Jan

AU - Rogdo, Bjarte

AU - Birkenmaier, Andre

AU - Meyer zu Bentrup, Friederike

AU - Fodor, Patricia

AU - Locher, Pascal

N1 - Funding Information: This work is endorsed by the Swiss Society of Intensive Care Medicine. We want to thank all nurses, physicians and other healthcare workers in our collaborating centers for their tireless and brave efforts in the care of their patients, without you this health care emergency could not be overcome. We thank Stephan M. Jakob, Yok-Ai Que, Anne-Aylin Sigg, Thierry Fumeaux, Philippe Guerci, Jonathan Montomoli, and Tanja Stadler for their invaluable help with this manuscript. The members of RISC-19-ICU Investigators for Switzerland: RISC-19-ICU Board (Matthias P. Hilty, MD; Reto A. Schüpbach, MD; Pedro D. Wendel Garcia, MSc; Thierry Fumeaux, MD; Philippe Guerci, MD Ph.D.; Jonathan Montomoli, MD Ph.D.); Institute of Intensive Care Medicine, University Hospital Zurich, Zurich (Reto A. Schüpbach MD; Silvio Brugger, MD, Ph.D.; Jan Bartussek, Ph.D.; Sascha David, MD; Stefanie Keiser, Ph.D.; Anne-Aylin Sigg; Annelies Zinkernagel, MD, Ph.D.); Soins intensifs, Groupement Hospitalier de l'Ouest Lémanique—Hopital de Nyon, Nyon (Mallory Moret-Bochatay, MD); Interdisziplinaere Intensivstation, Spital Buelach, Buelach (Bernd Yuen, MD; Thomas Hillermann, MD); Department for Intensive Care Medicine, Kantonsspital Nidwalden, Stans (Anette Ristic, MD; Michael Sepulcri, MD); Department of Anesthesiology and Intensive Care Medicine, Cantonal Hospital St. Gallen, St. Gallen (Miodrag Filipovic, MD; Urs Pietsch, MD); Intensivstation, Regionalspital Emmental AG, Burgdorf (Petra Salomon, MD; Iris Drvaric, MD); Institut fuer Anesthaesie und Intensivmedizin, Zuger Kantonsspital AG, Baar (Peter Schott, MD; Severin Urech, MD); Intensivmedizin, St. Claraspital, Basel (Adriana Lambert, MD; Lukas Merki, MD); Department Intensive Care Medicine, Spitalzentrum Biel, Biel (Marcus Laube, MD); Intensivmedizin, Kantonsspital Graubünden, Chur (Frank Hillgaertner, MD; Marianne Sieber); Institut fuer Anaesthesie und Intensivmedizin, Spital Thurgau, Frauenfeld (Alexander Dullenkopf, MD; Lina Petersen, MD); Division of Neonatal and Pediatric Intensive Care, Geneva University Hospitals, Geneva (Serge Grazioli, MD; Peter C. Rimensberger, MD); Soins Intensifs, Hirslanden Clinique Cecil, Lausanne (Isabelle Fleisch, MD; Jerome Lavanchy, MD); Pediatric Intensive Care Unit, University Hospital Lausanne, Lausanne (Marie-Helene Perez, MD); Interdisziplinaere Intensivstation, Spital Maennedorf AG, Maennedorf (Katharina Marquardt, MD; Karim Shaikh, MD); Intensivmedizin, Schweizer Paraplegikerzentrum Nottwil, Nottwil (Hermann Redecker, MD); Intensivmedizin, Spital Oberengadin, Samedan (Michael Stephan, MD; Jan Brem, MD); Paediatric Intensive Care Unit, Children’s Hospital of Eastern Switzerland, St. Gallen (Bjarte Rogdo, MD; Andre Birkenmaier, MD); Klinik für Anaesthesie und Intensivmedizin, Spitalzentrum Oberwallis, Visp (Friederike Meyer zu Bentrup, MD, MBA); Interdisziplinaere Intensivstation, Stadtspital Triemli, Zurich (Patricia Fodor, MD; Pascal Locher, MD); Department Intensivmedizin, Universitaetsspital Basel, Basel (Martin Siegemund, MD; Nuria Zellweger); Department of Intensive Care Medicine, University Hospital Bern—Inselspital, Bern (Stephan M Jakob, MD; Yok-Ai Que, MD Ph.D.; Marie-Madlen Jeitziner, RN, Ph.D.; Beatrice Jenni-Moser, RN, MSc); Interdisziplinaere Intensivmedizin, Lindenhofspital, Bern, Switzerland (Jan Wiegand, MD); Intensivstation, Spital Grabs, Grabs (Christian Bürkle, MD); Medical ICU, Cantonal Hospital St.Gallen, St. Gallen (Gian-Reto Kleger, MD); Service d'Anesthesiologie, EHNV, Yverdon-les-Bains (Marilene Franchitti Laurent, MD; Jean-Christophe Laurent, MD); Abteilung für Anaesthesiologie und Intensivmedizin, Hirslanden Klinik Im Park, Zürich (Tomislav Gaspert, MD; Marija Jovic, MD); Intensivmedizin & Intermediate Care, Kantonsspital Olten, Olten (Michael Studhalter, MD); Institut für Anaesthesiologie und Intensivmedizin, Klinik Hirslanden, Zurich (Christoph Haberthuer, MD; Roger F. Lussman, MD); Anaesthesie Intensivmedizin Schmerzmedizin, Spital Schwyz, Schwyz (Daniela Selz, MD; Didier Naon, MD); Dipartimento Area Critica, Clinica Luganese Moncucco, Lugano (Andrea Glotta, MD; Samuele Ceruti, MD); Institut für Anaesthesiologie Intensivmedizin & Rettungsmedizin, See-Spital Horgen & Kilchberg, Horgen (Julien Marrel, MD; Mirko Brenni, MD); Klinik für Operative Intensivmedizin, Kantonsspital Aarau, Aarau (Rolf Ensner, MD; Marc Michot, MD); Intensivstation, Kantonsspital Schaffhausen, Schaffhausen (Nadine Gehring, MD); Intensivstation, Spital Simmental-Thun-Saanenland AG, Thun (Antje Heise, MD); Klinik für Anaesthesie Intensivmedizin Operationszentrum und Schmerzmedizin, Kantonsspital Muensterlingen, Muensterlingen (Tobias Huebner, MD; Thomas A. Neff, MD); Division of Intensive Care, University Hospitals of Geneva, Geneva (Sara Cereghetti, MD; Filippo Boroli, MD; Jerome Pugin, MD, Ph.D.). Funding Information: This work is funded and endorsed by the Swiss Society of Intensive Care Medicine and unrestricted research grants by the Institute of Intensive Care Medicine at the University Hospital of Zurich, CytoSorbents Europe GmbH, Berlin, Germany, and Union Bancaire Privée, Geneva, Switzerland. The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

PY - 2022/3

Y1 - 2022/3

UR - http://www.scopus.com/inward/record.url?scp=85123414721&partnerID=8YFLogxK

U2 - https://doi.org/10.1007/s00134-021-06610-z

DO - https://doi.org/10.1007/s00134-021-06610-z

M3 - Comment/Letter to the editor

C2 - 35050384

SN - 0342-4642

VL - 48

SP - 362

EP - 365

JO - Intensive care medicine

JF - Intensive care medicine

IS - 3

ER -

mRNA-based SARS-CoV-2 vaccination is associated with reduced ICU admission rate and disease severity in critically ill COVID-19 patients treated in Switzerland

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