MUC1 in human milk blocks transmission of human immunodeficiency virus from dendritic cells to T cells

E. Saeland; M.A.W.P. de Jong; A. Nabatov; H. Kalay; Y. van Kooyk; T.B.H. Geijtenbeek

doi:https://doi.org/10.1016/j.molimm.2009.03.025

MUC1 in human milk blocks transmission of human immunodeficiency virus from dendritic cells to T cells

E. Saeland, M.A.W.P. de Jong, A. Nabatov, H. Kalay, Y. van Kooyk, T.B.H. Geijtenbeek

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Mother-to-child transmission of human immunodeficiency virus-1 (HIV-1) occurs frequently via breast-feeding. HIV-1 targets DC-SIGN+ dendritic cells (DCs) in mucosal areas that allow efficient transmission of the virus to T cells. Here, we demonstrate that the epithelial mucin MUC1, abundant in milk, efficiently bound to DC-SIGN on DC. The O-linked glycans within the mucin domain contained Lewis X structures, that were specifically recognized by the receptor. Interestingly, MUC1 prevented DC-SIGN-mediated transmission of HIV-1 from DCs to CD4+ T cells. We hypothesize that repetitive units of Lewis X, within the mucin domain, play an important role in inhibiting transmission of HIV-1 from mother to child. (C) 2009 Elsevier Ltd. All rights reserved

Original language	Undefined/Unknown
Pages (from-to)	2309-2316
Journal	Molecular immunology
Volume	46
Issue number	11-12
DOIs	https://doi.org/10.1016/j.molimm.2009.03.025
Publication status	Published - 2009

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https://doi.org/10.1016/j.molimm.2009.03.025

Cite this

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title = "MUC1 in human milk blocks transmission of human immunodeficiency virus from dendritic cells to T cells",

abstract = "Mother-to-child transmission of human immunodeficiency virus-1 (HIV-1) occurs frequently via breast-feeding. HIV-1 targets DC-SIGN+ dendritic cells (DCs) in mucosal areas that allow efficient transmission of the virus to T cells. Here, we demonstrate that the epithelial mucin MUC1, abundant in milk, efficiently bound to DC-SIGN on DC. The O-linked glycans within the mucin domain contained Lewis X structures, that were specifically recognized by the receptor. Interestingly, MUC1 prevented DC-SIGN-mediated transmission of HIV-1 from DCs to CD4+ T cells. We hypothesize that repetitive units of Lewis X, within the mucin domain, play an important role in inhibiting transmission of HIV-1 from mother to child. (C) 2009 Elsevier Ltd. All rights reserved",

author = "E. Saeland and {de Jong}, M.A.W.P. and A. Nabatov and H. Kalay and {van Kooyk}, Y. and T.B.H. Geijtenbeek",

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T1 - MUC1 in human milk blocks transmission of human immunodeficiency virus from dendritic cells to T cells

AU - Saeland, E.

AU - de Jong, M.A.W.P.

AU - Nabatov, A.

AU - Kalay, H.

AU - van Kooyk, Y.

AU - Geijtenbeek, T.B.H.

PY - 2009

Y1 - 2009

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AB - Mother-to-child transmission of human immunodeficiency virus-1 (HIV-1) occurs frequently via breast-feeding. HIV-1 targets DC-SIGN+ dendritic cells (DCs) in mucosal areas that allow efficient transmission of the virus to T cells. Here, we demonstrate that the epithelial mucin MUC1, abundant in milk, efficiently bound to DC-SIGN on DC. The O-linked glycans within the mucin domain contained Lewis X structures, that were specifically recognized by the receptor. Interestingly, MUC1 prevented DC-SIGN-mediated transmission of HIV-1 from DCs to CD4+ T cells. We hypothesize that repetitive units of Lewis X, within the mucin domain, play an important role in inhibiting transmission of HIV-1 from mother to child. (C) 2009 Elsevier Ltd. All rights reserved

U2 - https://doi.org/10.1016/j.molimm.2009.03.025

DO - https://doi.org/10.1016/j.molimm.2009.03.025

M3 - Article

C2 - 19406479

SN - 0161-5890

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