Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR

Christine Verbrugge, Marjon Al, Yehuda. G. Assaraf, Sarah Kammerer, Durga M. S. H. Chandrupatla, R.J. Honeywell, Rene P. J. Musters, Elisa Giovannetti, Tom O'Toole, George L. Scheffer, David Krige, Tanja D. de Gruijl, Johannes Niessen, Willem F. Lems, Pieternella A. Kramer, Rik J. Scheper, Jacqueline Cloos, Gert J. Ossenkoppele, Godefridus J. Peters, Gerrit Jansen

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Scopus)
Original languageEnglish
Pages (from-to)5240-5257
JournalOncotarget
Volume7
Issue number5
Publication statusPublished - 2 Feb 2016

Keywords

  • aminopeptidase
  • carboxylesterase
  • lipid droplets
  • mTOR
  • rapamycin

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