Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR

Christine Verbrugge; Marjon Al; Yehuda. G. Assaraf; Sarah Kammerer; Durga M. S. H. Chandrupatla; R.J. Honeywell; Rene P. J. Musters; Elisa Giovannetti; Tom O'Toole; George L. Scheffer; David Krige; Tanja D. de Gruijl; Johannes Niessen; Willem F. Lems; Pieternella A. Kramer; Rik J. Scheper; Jacqueline Cloos; Gert J. Ossenkoppele; Godefridus J. Peters; Gerrit Jansen

Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR

Christine Verbrugge, Marjon Al, Yehuda. G. Assaraf, Sarah Kammerer, Durga M. S. H. Chandrupatla, R.J. Honeywell, Rene P. J. Musters, Elisa Giovannetti, Tom O'Toole, George L. Scheffer, David Krige, Tanja D. de Gruijl, Johannes Niessen, Willem F. Lems, Pieternella A. Kramer, Rik J. Scheper, Jacqueline Cloos, Gert J. Ossenkoppele, Godefridus J. Peters, Gerrit Jansen

Research output: Contribution to journal › Article › Academic › peer-review

22 Citations (Scopus)

Original language	English
Pages (from-to)	5240-5257
Journal	Oncotarget
Volume	7
Issue number	5
Publication status	Published - 2 Feb 2016

Keywords

aminopeptidase
carboxylesterase
lipid droplets
mTOR
rapamycin

Cite this

Verbrugge, C., Al, M., Assaraf, Y. G., Kammerer, S., Chandrupatla, D. M. S. H., Honeywell, R. J., Musters, R. P. J., Giovannetti, E., O'Toole, T., Scheffer, G. L., Krige, D., de Gruijl, T. D., Niessen, J., Lems, W. F., Kramer, P. A., Scheper, R. J., Cloos, J., Ossenkoppele, G. J., Peters, G. J., & Jansen, G. (2016). Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR. Oncotarget, 7(5), 5240-5257.

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title = "Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR",

keywords = "aminopeptidase, carboxylesterase, lipid droplets, mTOR, rapamycin",

author = "Christine Verbrugge and Marjon Al and Assaraf, {Yehuda. G.} and Sarah Kammerer and Chandrupatla, {Durga M. S. H.} and R.J. Honeywell and Musters, {Rene P. J.} and Elisa Giovannetti and Tom O'Toole and Scheffer, {George L.} and David Krige and {de Gruijl}, {Tanja D.} and Johannes Niessen and Lems, {Willem F.} and Kramer, {Pieternella A.} and Scheper, {Rik J.} and Jacqueline Cloos and Ossenkoppele, {Gert J.} and Peters, {Godefridus J.} and Gerrit Jansen",

year = "2016",

month = feb,

day = "2",

language = "English",

volume = "7",

pages = "5240--5257",

journal = "Oncotarget",

issn = "1949-2553",

publisher = "Impact Journals",

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}

Verbrugge, C, Al, M, Assaraf, YG, Kammerer, S, Chandrupatla, DMSH, Honeywell, RJ, Musters, RPJ, Giovannetti, E, O'Toole, T, Scheffer, GL, Krige, D, de Gruijl, TD , Niessen, J , Lems, WF, Kramer, PA, Scheper, RJ , Cloos, J , Ossenkoppele, GJ , Peters, GJ & Jansen, G 2016, 'Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR', Oncotarget, vol. 7, no. 5, pp. 5240-5257.

Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR. / Verbrugge, Christine; Al, Marjon; Assaraf, Yehuda. G. et al.
In: Oncotarget, Vol. 7, No. 5, 02.02.2016, p. 5240-5257.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR

AU - Verbrugge, Christine

AU - Al, Marjon

AU - Assaraf, Yehuda. G.

AU - Kammerer, Sarah

AU - Chandrupatla, Durga M. S. H.

AU - Honeywell, R.J.

AU - Musters, Rene P. J.

AU - Giovannetti, Elisa

AU - O'Toole, Tom

AU - Scheffer, George L.

AU - Krige, David

AU - de Gruijl, Tanja D.

AU - Niessen, Johannes

AU - Lems, Willem F.

AU - Kramer, Pieternella A.

AU - Scheper, Rik J.

AU - Cloos, Jacqueline

AU - Ossenkoppele, Gert J.

AU - Peters, Godefridus J.

AU - Jansen, Gerrit

PY - 2016/2/2

Y1 - 2016/2/2

KW - aminopeptidase

KW - carboxylesterase

KW - lipid droplets

KW - mTOR

KW - rapamycin

M3 - Article

SN - 1949-2553

VL - 7

SP - 5240

EP - 5257

JO - Oncotarget

JF - Oncotarget

IS - 5

ER -