TY - JOUR
T1 - Multiple biomarkers at admission are associated with angiographic, electrocardiographic, and imaging cardiovascular mechanistic markers of outcomes in patients undergoing primary percutaneous coronary intervention for acute ST-elevation myocardial infarction
AU - Damman, Peter
AU - Kuijt, Wichert J.
AU - Woudstra, Pier
AU - Haeck, Joost D. E.
AU - Koch, Karel T.
AU - Gu, Youlan L.
AU - van Straalen, Jan P.
AU - Fischer, Johan
AU - Tijssen, Jan G. P.
AU - Krucoff, Mitchell W.
AU - de Winter, Robbert J.
PY - 2012
Y1 - 2012
N2 - Background The multimarker risk score, based on estimated glomerular filtration rate, glucose, and N-terminal probrain natriuretic peptide (NT-proBNP), has been shown to predict mortality in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). In this study, we investigated the relation between the multimarker risk score and cardiovascular mechanistic markers of outcomes in STEMI patients undergoing PPCI. Methods Complete biomarkers were available in 197 patients with STEMI. Angiographic Thrombolysis In Myocardial Infarction flow grade and myocardial blush grade at the end of the PPCI, electrocardiographic ST-segment resolution (STR) at the time of last contrast injection and 240 minutes after last contrast, and cardiac magnetic resonance (CMR) left ventricular ejection fraction (LVEF) and infarct size at 4 to 6 months after the index event were available. Results In linear regression models, higher multimarker scores were associated with worse angiographic (P <.01 for both outcomes), electrocardiographic (P <.001 for the association with STR at last contrast, and P <.01 for STR at 240 minutes), and CMR outcomes (P <.01 for both). Conlusions The multimarker risk score is associated with angiographic, electrocardiographic, and CMR mechanistic markers of outcomes. These data support the ability of the multimarker risk score to identify patients at high risk for suboptimal reperfusion and CMR outcomes and may aid in the early triage of patients who stand to benefit most of adjuvant treatments in STEMI. (Am Heart J 2012;163:783-9.)
AB - Background The multimarker risk score, based on estimated glomerular filtration rate, glucose, and N-terminal probrain natriuretic peptide (NT-proBNP), has been shown to predict mortality in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). In this study, we investigated the relation between the multimarker risk score and cardiovascular mechanistic markers of outcomes in STEMI patients undergoing PPCI. Methods Complete biomarkers were available in 197 patients with STEMI. Angiographic Thrombolysis In Myocardial Infarction flow grade and myocardial blush grade at the end of the PPCI, electrocardiographic ST-segment resolution (STR) at the time of last contrast injection and 240 minutes after last contrast, and cardiac magnetic resonance (CMR) left ventricular ejection fraction (LVEF) and infarct size at 4 to 6 months after the index event were available. Results In linear regression models, higher multimarker scores were associated with worse angiographic (P <.01 for both outcomes), electrocardiographic (P <.001 for the association with STR at last contrast, and P <.01 for STR at 240 minutes), and CMR outcomes (P <.01 for both). Conlusions The multimarker risk score is associated with angiographic, electrocardiographic, and CMR mechanistic markers of outcomes. These data support the ability of the multimarker risk score to identify patients at high risk for suboptimal reperfusion and CMR outcomes and may aid in the early triage of patients who stand to benefit most of adjuvant treatments in STEMI. (Am Heart J 2012;163:783-9.)
U2 - https://doi.org/10.1016/j.ahj.2012.01.004
DO - https://doi.org/10.1016/j.ahj.2012.01.004
M3 - Article
C2 - 22607855
SN - 0002-8703
VL - 163
SP - 783
EP - 789
JO - American Heart Journal
JF - American Heart Journal
IS - 5
ER -