TY - JOUR
T1 - Multivariate analysis reveals anatomical correlates of naming errors in primary progressive aphasia
AU - Bruffaerts, Rose
AU - Schaeverbeke, Jolien
AU - de Weer, An-Sofie
AU - Nelissen, Natalie
AU - Dries, Eva
AU - van Bouwel, Karen
AU - Sieben, Anne
AU - Bergmans, Bruno
AU - Swinnen, Charlotte
AU - Pijnenburg, Yolande
AU - Sunaert, Stefan
AU - Vandenbulcke, Mathieu
AU - Vandenberghe, Rik
PY - 2020/4/1
Y1 - 2020/4/1
N2 - Primary progressive aphasia (PPA) is an overarching term for a heterogeneous group of neurodegenerative diseases which affect language processing. Impaired picture naming has been linked to atrophy of the anterior temporal lobe in the semantic variant of PPA. Although atrophy of the anterior temporal lobe proposedly impairs picture naming by undermining access to semantic knowledge, picture naming also entails object recognition and lexical retrieval. Using multivariate analysis, we investigated whether cortical atrophy relates to different types of naming errors generated during picture naming in 43 PPA patients (13 semantic, 9 logopenic, 11 nonfluent, and 10 mixed variant). Omissions were associated with atrophy of the anterior temporal lobes. Semantic errors, for example, mistaking a rhinoceros for a hippopotamus, were associated with atrophy of the left mid and posterior fusiform cortex and the posterior middle and inferior temporal gyrus. Semantic errors and atrophy in these regions occurred in each PPA subtype, without major between-subtype differences. We propose that pathological changes to neural mechanisms associated with semantic errors occur across the PPA spectrum.
AB - Primary progressive aphasia (PPA) is an overarching term for a heterogeneous group of neurodegenerative diseases which affect language processing. Impaired picture naming has been linked to atrophy of the anterior temporal lobe in the semantic variant of PPA. Although atrophy of the anterior temporal lobe proposedly impairs picture naming by undermining access to semantic knowledge, picture naming also entails object recognition and lexical retrieval. Using multivariate analysis, we investigated whether cortical atrophy relates to different types of naming errors generated during picture naming in 43 PPA patients (13 semantic, 9 logopenic, 11 nonfluent, and 10 mixed variant). Omissions were associated with atrophy of the anterior temporal lobes. Semantic errors, for example, mistaking a rhinoceros for a hippopotamus, were associated with atrophy of the left mid and posterior fusiform cortex and the posterior middle and inferior temporal gyrus. Semantic errors and atrophy in these regions occurred in each PPA subtype, without major between-subtype differences. We propose that pathological changes to neural mechanisms associated with semantic errors occur across the PPA spectrum.
KW - Language
KW - Picture naming
KW - Primary progressive aphasia
KW - Semantic dementia
KW - Semantic errors
KW - Volumetric analysis
UR - http://www.scopus.com/inward/record.url?scp=85078058744&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.neurobiolaging.2019.12.016
DO - https://doi.org/10.1016/j.neurobiolaging.2019.12.016
M3 - Article
C2 - 31955981
SN - 0197-4580
VL - 88
SP - 71
EP - 82
JO - Neurobiology of Aging
JF - Neurobiology of Aging
ER -