Munc18-1 Regulates First-phase Insulin Release by Promoting Granule Docking to Multiple Syntaxin Isoforms

E. Oh, M.A. Kalwat, M.J. Kim, M. Verhage, D.C. Thurmond

Research output: Contribution to journalArticleAcademicpeer-review

58 Citations (Scopus)

Abstract

Attenuated levels of the Sec1/Munc18 (SM) protein Munc18-1 in human islet β-cells is coincident with type 2 diabetes, although how Munc18-1 facilitates insulin secretion remains enigmatic. Herein, using conventional Munc18-1
Original languageEnglish
Pages (from-to)25821-25833
JournalJournal of Biological Chemistry
Volume287
Issue number31
DOIs
Publication statusPublished - 2012

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