N-ras mutations in human cutaneous melanoma from sun-exposed body sites

L. J. van 't Veer; B. M. Burgering; R. Versteeg; A. J. Boot; D. J. Ruiter; S. Osanto; P. I. Schrier; J. L. Bos

doi:https://doi.org/10.1128/MCB.9.7.3114

N-ras mutations in human cutaneous melanoma from sun-exposed body sites

L. J. van 't Veer, B. M. Burgering, R. Versteeg, A. J. Boot, D. J. Ruiter, S. Osanto, P. I. Schrier, J. L. Bos

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Research output: Contribution to journal › Comment/Letter to the editor › Academic

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Abstract

In 7 of 37 patients with cutaneous melanoma, mutations in the N-ras gene were found. The primary tumors of these seven patients were exclusively localized on body sites continuously exposed to sunlight. Moreover, the ras mutations were all at or near dipyrimidine sites known to be targets of UV damage. Two primary tumors were biclonal with respect to ras mutation. An active role for UV irradiation in induction of the mutations is suggested

Original language	English
Pages (from-to)	3114-3116
Journal	Molecular and Cellular Biology
Volume	9
Issue number	7
DOIs	https://doi.org/10.1128/MCB.9.7.3114
Publication status	Published - 1989

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https://doi.org/10.1128/MCB.9.7.3114

Cite this

@article{36f0e836c8624c8abc1b352cbb9f1d4f,

title = "N-ras mutations in human cutaneous melanoma from sun-exposed body sites",

abstract = "In 7 of 37 patients with cutaneous melanoma, mutations in the N-ras gene were found. The primary tumors of these seven patients were exclusively localized on body sites continuously exposed to sunlight. Moreover, the ras mutations were all at or near dipyrimidine sites known to be targets of UV damage. Two primary tumors were biclonal with respect to ras mutation. An active role for UV irradiation in induction of the mutations is suggested",

author = "{van 't Veer}, {L. J.} and Burgering, {B. M.} and R. Versteeg and Boot, {A. J.} and Ruiter, {D. J.} and S. Osanto and Schrier, {P. I.} and Bos, {J. L.}",

year = "1989",

doi = "https://doi.org/10.1128/MCB.9.7.3114",

language = "English",

volume = "9",

pages = "3114--3116",

journal = "Molecular and Cellular Biology",

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publisher = "American Society for Microbiology",

number = "7",

}

TY - JOUR

T1 - N-ras mutations in human cutaneous melanoma from sun-exposed body sites

AU - van 't Veer, L. J.

AU - Burgering, B. M.

AU - Versteeg, R.

AU - Boot, A. J.

AU - Ruiter, D. J.

AU - Osanto, S.

AU - Schrier, P. I.

AU - Bos, J. L.

PY - 1989

Y1 - 1989

N2 - In 7 of 37 patients with cutaneous melanoma, mutations in the N-ras gene were found. The primary tumors of these seven patients were exclusively localized on body sites continuously exposed to sunlight. Moreover, the ras mutations were all at or near dipyrimidine sites known to be targets of UV damage. Two primary tumors were biclonal with respect to ras mutation. An active role for UV irradiation in induction of the mutations is suggested

AB - In 7 of 37 patients with cutaneous melanoma, mutations in the N-ras gene were found. The primary tumors of these seven patients were exclusively localized on body sites continuously exposed to sunlight. Moreover, the ras mutations were all at or near dipyrimidine sites known to be targets of UV damage. Two primary tumors were biclonal with respect to ras mutation. An active role for UV irradiation in induction of the mutations is suggested

U2 - https://doi.org/10.1128/MCB.9.7.3114

DO - https://doi.org/10.1128/MCB.9.7.3114

M3 - Comment/Letter to the editor

C2 - 2674680

SN - 0270-7306

VL - 9

SP - 3114

EP - 3116

JO - Molecular and Cellular Biology

JF - Molecular and Cellular Biology

IS - 7

ER -