Nakaseomyces glabrata endocarditis: A therapeutic dilemma

Kin Ki Jim; Joelle J. N. Daems; S. Matthijs Boekholdt; Karin van Dijk

doi:https://doi.org/10.1016/j.mmcr.2023.04.002

Nakaseomyces glabrata endocarditis: A therapeutic dilemma

Kin Ki Jim, Joelle J. N. Daems, S. Matthijs Boekholdt, Karin van Dijk

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Candida infective endocarditis is a rare but serious entity that often requires aggressive treatment. However, treatment can be challenging in patients infected with drug-resistant fungi and/or with substantial comorbidity. Moreover, recommendations in treatment guidelines for these patients are based on limited clinical data due to their rarity. Here we report a case of Nakaseomyces glabrata (Candida glabrata) prosthetic valve endocarditis in a patient with congenital heart disease. This case illustrates a therapeutic dilemma for Nakaseomyces glabrata prosthetic valve endocarditis and the need for novel antifungal drugs and further clinical studies.

Original language	English
Pages (from-to)	54-57
Number of pages	4
Journal	MEDICAL MYCOLOGY CASE REPORTS
Volume	40
DOIs	https://doi.org/10.1016/j.mmcr.2023.04.002
Publication status	Published - 1 Jun 2023

Keywords

Anti-fungal therapy
Candida glabrata
Endocarditis
Invasive candidiasis
Nakaseomyces glabrata

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https://doi.org/10.1016/j.mmcr.2023.04.002

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title = "Nakaseomyces glabrata endocarditis: A therapeutic dilemma",

abstract = "Candida infective endocarditis is a rare but serious entity that often requires aggressive treatment. However, treatment can be challenging in patients infected with drug-resistant fungi and/or with substantial comorbidity. Moreover, recommendations in treatment guidelines for these patients are based on limited clinical data due to their rarity. Here we report a case of Nakaseomyces glabrata (Candida glabrata) prosthetic valve endocarditis in a patient with congenital heart disease. This case illustrates a therapeutic dilemma for Nakaseomyces glabrata prosthetic valve endocarditis and the need for novel antifungal drugs and further clinical studies.",

keywords = "Anti-fungal therapy, Candida glabrata, Endocarditis, Invasive candidiasis, Nakaseomyces glabrata",

author = "Jim, {Kin Ki} and Daems, {Joelle J. N.} and Boekholdt, {S. Matthijs} and {van Dijk}, Karin",

note = "Funding Information: We would like to thank Dr. Jochem Buil, Dr. Roger Br{\"u}ggemann, Dr. Nico Jansen, Dr. M. Erg{\"u}n. and Prof. Paul Verweij (Center of Expertise for Mycology, Radboudumc-CWZ, Nijmegen, The Netherlands) for clinical consultation. Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

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doi = "https://doi.org/10.1016/j.mmcr.2023.04.002",

language = "English",

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T2 - A therapeutic dilemma

AU - Jim, Kin Ki

AU - Daems, Joelle J. N.

AU - Boekholdt, S. Matthijs

AU - van Dijk, Karin

N1 - Funding Information: We would like to thank Dr. Jochem Buil, Dr. Roger Brüggemann, Dr. Nico Jansen, Dr. M. Ergün. and Prof. Paul Verweij (Center of Expertise for Mycology, Radboudumc-CWZ, Nijmegen, The Netherlands) for clinical consultation. Publisher Copyright: © 2023 The Authors

PY - 2023/6/1

Y1 - 2023/6/1

N2 - Candida infective endocarditis is a rare but serious entity that often requires aggressive treatment. However, treatment can be challenging in patients infected with drug-resistant fungi and/or with substantial comorbidity. Moreover, recommendations in treatment guidelines for these patients are based on limited clinical data due to their rarity. Here we report a case of Nakaseomyces glabrata (Candida glabrata) prosthetic valve endocarditis in a patient with congenital heart disease. This case illustrates a therapeutic dilemma for Nakaseomyces glabrata prosthetic valve endocarditis and the need for novel antifungal drugs and further clinical studies.

AB - Candida infective endocarditis is a rare but serious entity that often requires aggressive treatment. However, treatment can be challenging in patients infected with drug-resistant fungi and/or with substantial comorbidity. Moreover, recommendations in treatment guidelines for these patients are based on limited clinical data due to their rarity. Here we report a case of Nakaseomyces glabrata (Candida glabrata) prosthetic valve endocarditis in a patient with congenital heart disease. This case illustrates a therapeutic dilemma for Nakaseomyces glabrata prosthetic valve endocarditis and the need for novel antifungal drugs and further clinical studies.

KW - Anti-fungal therapy

KW - Candida glabrata

KW - Endocarditis

KW - Invasive candidiasis

KW - Nakaseomyces glabrata

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U2 - https://doi.org/10.1016/j.mmcr.2023.04.002

DO - https://doi.org/10.1016/j.mmcr.2023.04.002

M3 - Article

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SN - 2211-7539

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JO - MEDICAL MYCOLOGY CASE REPORTS

JF - MEDICAL MYCOLOGY CASE REPORTS

ER -

Nakaseomyces glabrata endocarditis: A therapeutic dilemma

Abstract

Keywords

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