Nance-Horan syndrome: linkage analysis in a family from The Netherlands

A. A. Bergen, J. ten Brink, E. J. Schuurman, E. M. Bleeker-Wagemakers

Research output: Contribution to journalComment/Letter to the editorAcademic

10 Citations (Scopus)


Linkage analysis was carried out in a Dutch family with Nance-Horan (NH) syndrome. Close linkage without recombination between NH and the Xp loci DXS207, DXS43, and DXS365 (zmax = 3.23) was observed. Multipoint linkage analysis and the analysis of recombinations in multiple informative meioses suggest the genetic order Xcen-DMD (exon 49)-DXS451-(NH, DXS207, DXS365, DXS43)-(STS, DXF30)-Xpter. These data refine the localization of the NH locus on the distal Xp
Original languageEnglish
Pages (from-to)238-240
Issue number1
Publication statusPublished - 1994

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