Natural killer cells and anti-cancer therapies: Reciprocal effects on immune function and therapeutic response

Elisa C. Toffoli; Abdolkarim Sheikhi; Yannick D. Höppner; Pita de Kok; Mahsa Yazdanpanah-Samani; Jan Spanholtz; Henk M.W. Verheul; Hans J. van der Vliet; Tanja D. de Gruijl

doi:https://doi.org/10.3390/cancers13040711

Natural killer cells and anti-cancer therapies: Reciprocal effects on immune function and therapeutic response

Elisa C. Toffoli, Abdolkarim Sheikhi, Yannick D. Höppner, Pita de Kok, Mahsa Yazdanpanah-Samani, Jan Spanholtz, Henk M.W. Verheul, Hans J. van der Vliet, Tanja D. de Gruijl

Research output: Contribution to journal › Review article › Academic › peer-review

12 Citations (Scopus)

Abstract

Natural Killer (NK) cells are innate immune cells with the unique ability to recognize and kill virus-infected and cancer cells without prior immune sensitization. Due to their expression of the Fc receptor CD16, effector NK cells can kill tumor cells through antibody-dependent cytotoxicity, making them relevant players in antibody-based cancer therapies. The role of NK cells in other approved and experimental anti-cancer therapies is more elusive. Here, we review the possible role of NK cells in the efficacy of various anti-tumor therapies, including radiotherapy, chemotherapy, and immunotherapy, as well as the impact of these therapies on NK cell function.

Original language	English
Article number	711
Pages (from-to)	1-27
Number of pages	27
Journal	Cancers
Volume	13
Issue number	4
DOIs	https://doi.org/10.3390/cancers13040711
Publication status	Published - 2 Feb 2021

Keywords

Anti-cancer therapies
Cancer
Checkpoint inhibitors
Chemotherapy
Local ablation therapies
NK cells
Oncolytic virus
Protein kinase inhibitors
Radiotherapy

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title = "Natural killer cells and anti-cancer therapies: Reciprocal effects on immune function and therapeutic response",

abstract = "Natural Killer (NK) cells are innate immune cells with the unique ability to recognize and kill virus-infected and cancer cells without prior immune sensitization. Due to their expression of the Fc receptor CD16, effector NK cells can kill tumor cells through antibody-dependent cytotoxicity, making them relevant players in antibody-based cancer therapies. The role of NK cells in other approved and experimental anti-cancer therapies is more elusive. Here, we review the possible role of NK cells in the efficacy of various anti-tumor therapies, including radiotherapy, chemotherapy, and immunotherapy, as well as the impact of these therapies on NK cell function.",

keywords = "Anti-cancer therapies, Cancer, Checkpoint inhibitors, Chemotherapy, Local ablation therapies, NK cells, Oncolytic virus, Protein kinase inhibitors, Radiotherapy",

author = "Toffoli, {Elisa C.} and Abdolkarim Sheikhi and H{\"o}ppner, {Yannick D.} and {de Kok}, Pita and Mahsa Yazdanpanah-Samani and Jan Spanholtz and Verheul, {Henk M.W.} and {van der Vliet}, {Hans J.} and {de Gruijl}, {Tanja D.}",

note = "Funding Information: Funding: This work was supported by a research grant from Glycostem BV and a grant (DUMS-1397-3-19-1121) from the Dezful University of Medical Sciences. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

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doi = "https://doi.org/10.3390/cancers13040711",

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AU - Toffoli, Elisa C.

AU - Sheikhi, Abdolkarim

AU - Höppner, Yannick D.

AU - de Kok, Pita

AU - Yazdanpanah-Samani, Mahsa

AU - Spanholtz, Jan

AU - Verheul, Henk M.W.

AU - van der Vliet, Hans J.

AU - de Gruijl, Tanja D.

N1 - Funding Information: Funding: This work was supported by a research grant from Glycostem BV and a grant (DUMS-1397-3-19-1121) from the Dezful University of Medical Sciences. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/2/2

Y1 - 2021/2/2

N2 - Natural Killer (NK) cells are innate immune cells with the unique ability to recognize and kill virus-infected and cancer cells without prior immune sensitization. Due to their expression of the Fc receptor CD16, effector NK cells can kill tumor cells through antibody-dependent cytotoxicity, making them relevant players in antibody-based cancer therapies. The role of NK cells in other approved and experimental anti-cancer therapies is more elusive. Here, we review the possible role of NK cells in the efficacy of various anti-tumor therapies, including radiotherapy, chemotherapy, and immunotherapy, as well as the impact of these therapies on NK cell function.

AB - Natural Killer (NK) cells are innate immune cells with the unique ability to recognize and kill virus-infected and cancer cells without prior immune sensitization. Due to their expression of the Fc receptor CD16, effector NK cells can kill tumor cells through antibody-dependent cytotoxicity, making them relevant players in antibody-based cancer therapies. The role of NK cells in other approved and experimental anti-cancer therapies is more elusive. Here, we review the possible role of NK cells in the efficacy of various anti-tumor therapies, including radiotherapy, chemotherapy, and immunotherapy, as well as the impact of these therapies on NK cell function.

KW - Anti-cancer therapies

KW - Cancer

KW - Checkpoint inhibitors

KW - Chemotherapy

KW - Local ablation therapies

KW - NK cells

KW - Oncolytic virus

KW - Protein kinase inhibitors

KW - Radiotherapy

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M3 - Review article

C2 - 33572396

SN - 2072-6694

VL - 13

SP - 1

EP - 27

JO - Cancers

JF - Cancers

IS - 4

M1 - 711

ER -

Natural killer cells and anti-cancer therapies: Reciprocal effects on immune function and therapeutic response

Abstract

Keywords

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