Nerve ultrasound shows subclinical peripheral nerve involvement in neurofibromatosis type 2

Johan A. Telleman, Menno D. Stellingwerff, Geert J. Brekelmans, Leo H. Visser

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Introduction: Neurofibromatosis type 2 (NF2) is mainly associated with central nervous system (CNS) tumors. Peripheral nerve involvement is described in symptomatic patients, but evidence of subclinical peripheral nerve involvement is scarce. Methods: We conducted a cross-sectional pilot study in 2 asymptomatic and 3 minimally symptomatic patients with NF2 to detect subclinical peripheral nerve involvement. Patients underwent clinical examination, nerve conduction studies (NCS), and high-resolution ultrasonography (HRUS). Results: A total of 30 schwannomas were found, divided over 20 nerve segments (33.9% of all investigated nerve segments). All patients had at least 1 schwannoma. Schwannomas were identified with HRUS in 37% of clinically unaffected nerve segments and 50% of nerve segments with normal NCS findings. Discussion: HRUS shows frequent subclinical peripheral nerve involvement in NF2. Clinicians should consider peripheral nerve involvement as a cause of weakness and sensory loss in the extremities in patients with this disease. Muscle Nerve 57: 312–316, 2018.

Original languageEnglish
Pages (from-to)312-316
Number of pages5
JournalMuscle and Nerve
Issue number2
Publication statusPublished - 1 Feb 2018


  • asymptomatic
  • neurofibromatosis type 2
  • neuropathy
  • peripheral nerve sheath tumors
  • sonography
  • subclinical

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