TY - JOUR
T1 - Network-based asymmetry of the human auditory system
AU - Mišić, Bratislav
AU - Betzel, Richard F.
AU - Griffa, Alessandra
AU - De Reus, Marcel A.
AU - He, Ye
AU - Zuo, Xi Nian
AU - Van Den Heuvel, Martijn P.
AU - Hagmann, Patric
AU - Sporns, Olaf
AU - Zatorre, Robert J.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Converging evidence from activation, connectivity, and stimulation studies suggests that auditory brain networks are lateralized. Here we show that these findings can be at least partly explained by the asymmetric network embedding of the primary auditory cortices. Using diffusion-weighted imaging in 3 independent datasets, we investigate the propensity for left and right auditory cortex to communicate with other brain areas by quantifying the centrality of the auditory network across a spectrum of communication mechanisms, from shortest path communication to diffusive spreading. Across all datasets, we find that the right auditory cortex is better integrated in the connectome, facilitating more efficient communication with other areas, with much of the asymmetry driven by differences in communication pathways to the opposite hemisphere. Critically, the primacy of the right auditory cortex emerges only when communication is conceptualized as a diffusive process, taking advantage of more than just the topologically shortest paths in the network. Altogether, these results highlight how the network configuration and embedding of a particular region may contribute to its functional lateralization.
AB - Converging evidence from activation, connectivity, and stimulation studies suggests that auditory brain networks are lateralized. Here we show that these findings can be at least partly explained by the asymmetric network embedding of the primary auditory cortices. Using diffusion-weighted imaging in 3 independent datasets, we investigate the propensity for left and right auditory cortex to communicate with other brain areas by quantifying the centrality of the auditory network across a spectrum of communication mechanisms, from shortest path communication to diffusive spreading. Across all datasets, we find that the right auditory cortex is better integrated in the connectome, facilitating more efficient communication with other areas, with much of the asymmetry driven by differences in communication pathways to the opposite hemisphere. Critically, the primacy of the right auditory cortex emerges only when communication is conceptualized as a diffusive process, taking advantage of more than just the topologically shortest paths in the network. Altogether, these results highlight how the network configuration and embedding of a particular region may contribute to its functional lateralization.
KW - Auditory
KW - Connectome
KW - Network
KW - Spreading
UR - http://www.scopus.com/inward/record.url?scp=85049962100&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049962100&partnerID=8YFLogxK
U2 - https://doi.org/10.1093/cercor/bhy101
DO - https://doi.org/10.1093/cercor/bhy101
M3 - Article
C2 - 29722805
SN - 1047-3211
VL - 28
SP - 2655
EP - 2664
JO - Cerebral cortex (New York, N.Y. : 1991)
JF - Cerebral cortex (New York, N.Y. : 1991)
IS - 7
ER -