The aim of this study is to analyze the relation between myocardial oxygen consumption (MVO2) and end-systolic volume (ESV) in dependence of adrenergic stimulation or blockade in the normal left ventricle. We analyzed MVO2 and volumetric data of five chronically instrumented dogs measured during rest and exercise, while protocols were performed with and without beta-blockade. Then we constructed their overall Alternative Starling Curve (ASC) by plotting ESV versus end-diastolic volume (EDV). Subsequently, we carried out an analysis, while employing an extended model compared with the Pressure-Volume-Area (PVA) for MVO2 prediction as originally proposed by Suga. This mathematical model is validated by comparison with pertinent data obtained by labeled C-acetate PET studies in healthy humans. Our results indicate a close resemblance between theoretically predicted MVO2 data and actual measurements performed in humans and dogs. In addition, this study suggests neural modulation of the MVO2-ESV relationship by illustrating the effects of various adrenergic interventions.
|Number of pages||2|
|Publication status||Published - 1 Dec 1995|
|Event||Proceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2) - Montreal, Can|
Duration: 20 Sept 1995 → 23 Sept 1995
|Conference||Proceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2)|
|Period||20/09/1995 → 23/09/1995|