Neural modulation of myocardial oxygen consumption: experiments and model study based on the alternative starling curve description

P. L.M. Kerkhof; M. F. Weber; J. L.J. Vanoverschelde; C. P. Cheng

Neural modulation of myocardial oxygen consumption: experiments and model study based on the alternative starling curve description

P. L.M. Kerkhof, M. F. Weber, J. L.J. Vanoverschelde, C. P. Cheng

Radiology and Nuclear Medicine (VUmc)

Research output: Contribution to conference › Paper › Academic

4 Citations (Scopus)

Abstract

The aim of this study is to analyze the relation between myocardial oxygen consumption (MVO₂) and end-systolic volume (ESV) in dependence of adrenergic stimulation or blockade in the normal left ventricle. We analyzed MVO₂ and volumetric data of five chronically instrumented dogs measured during rest and exercise, while protocols were performed with and without beta-blockade. Then we constructed their overall Alternative Starling Curve (ASC) by plotting ESV versus end-diastolic volume (EDV). Subsequently, we carried out an analysis, while employing an extended model compared with the Pressure-Volume-Area (PVA) for MVO₂ prediction as originally proposed by Suga. This mathematical model is validated by comparison with pertinent data obtained by labeled C-acetate PET studies in healthy humans. Our results indicate a close resemblance between theoretically predicted MVO₂ data and actual measurements performed in humans and dogs. In addition, this study suggests neural modulation of the MVO₂-ESV relationship by illustrating the effects of various adrenergic interventions.

Original language	English
Pages	115-116
Number of pages	2
Publication status	Published - 1 Dec 1995
Event	Proceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2) - Montreal, Can Duration: 20 Sept 1995 → 23 Sept 1995

Conference

Conference	Proceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2)
City	Montreal, Can
Period	20/09/1995 → 23/09/1995

Cite this

Kerkhof, P. L. M., Weber, M. F., Vanoverschelde, J. L. J., & Cheng, C. P. (1995). Neural modulation of myocardial oxygen consumption: experiments and model study based on the alternative starling curve description. 115-116. Paper presented at Proceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2), Montreal, Can.

Kerkhof, P. L.M. ; Weber, M. F. ; Vanoverschelde, J. L.J. et al. / Neural modulation of myocardial oxygen consumption : experiments and model study based on the alternative starling curve description. Paper presented at Proceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2), Montreal, Can.2 p.

@conference{b53d904b08744717865900501cedbdd7,

title = "Neural modulation of myocardial oxygen consumption: experiments and model study based on the alternative starling curve description",

abstract = "The aim of this study is to analyze the relation between myocardial oxygen consumption (MVO2) and end-systolic volume (ESV) in dependence of adrenergic stimulation or blockade in the normal left ventricle. We analyzed MVO2 and volumetric data of five chronically instrumented dogs measured during rest and exercise, while protocols were performed with and without beta-blockade. Then we constructed their overall Alternative Starling Curve (ASC) by plotting ESV versus end-diastolic volume (EDV). Subsequently, we carried out an analysis, while employing an extended model compared with the Pressure-Volume-Area (PVA) for MVO2 prediction as originally proposed by Suga. This mathematical model is validated by comparison with pertinent data obtained by labeled C-acetate PET studies in healthy humans. Our results indicate a close resemblance between theoretically predicted MVO2 data and actual measurements performed in humans and dogs. In addition, this study suggests neural modulation of the MVO2-ESV relationship by illustrating the effects of various adrenergic interventions.",

author = "Kerkhof, {P. L.M.} and Weber, {M. F.} and Vanoverschelde, {J. L.J.} and Cheng, {C. P.}",

year = "1995",

month = dec,

day = "1",

language = "English",

pages = "115--116",

note = "Proceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2) ; Conference date: 20-09-1995 Through 23-09-1995",

}

Kerkhof, PLM, Weber, MF, Vanoverschelde, JLJ & Cheng, CP 1995, 'Neural modulation of myocardial oxygen consumption: experiments and model study based on the alternative starling curve description', Paper presented at Proceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2), Montreal, Can, 20/09/1995 - 23/09/1995 pp. 115-116.

Neural modulation of myocardial oxygen consumption: experiments and model study based on the alternative starling curve description. / Kerkhof, P. L.M.; Weber, M. F.; Vanoverschelde, J. L.J. et al.
1995. 115-116 Paper presented at Proceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2), Montreal, Can.

Research output: Contribution to conference › Paper › Academic

TY - CONF

T1 - Neural modulation of myocardial oxygen consumption

T2 - Proceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2)

AU - Kerkhof, P. L.M.

AU - Weber, M. F.

AU - Vanoverschelde, J. L.J.

AU - Cheng, C. P.

PY - 1995/12/1

Y1 - 1995/12/1

N2 - The aim of this study is to analyze the relation between myocardial oxygen consumption (MVO2) and end-systolic volume (ESV) in dependence of adrenergic stimulation or blockade in the normal left ventricle. We analyzed MVO2 and volumetric data of five chronically instrumented dogs measured during rest and exercise, while protocols were performed with and without beta-blockade. Then we constructed their overall Alternative Starling Curve (ASC) by plotting ESV versus end-diastolic volume (EDV). Subsequently, we carried out an analysis, while employing an extended model compared with the Pressure-Volume-Area (PVA) for MVO2 prediction as originally proposed by Suga. This mathematical model is validated by comparison with pertinent data obtained by labeled C-acetate PET studies in healthy humans. Our results indicate a close resemblance between theoretically predicted MVO2 data and actual measurements performed in humans and dogs. In addition, this study suggests neural modulation of the MVO2-ESV relationship by illustrating the effects of various adrenergic interventions.

AB - The aim of this study is to analyze the relation between myocardial oxygen consumption (MVO2) and end-systolic volume (ESV) in dependence of adrenergic stimulation or blockade in the normal left ventricle. We analyzed MVO2 and volumetric data of five chronically instrumented dogs measured during rest and exercise, while protocols were performed with and without beta-blockade. Then we constructed their overall Alternative Starling Curve (ASC) by plotting ESV versus end-diastolic volume (EDV). Subsequently, we carried out an analysis, while employing an extended model compared with the Pressure-Volume-Area (PVA) for MVO2 prediction as originally proposed by Suga. This mathematical model is validated by comparison with pertinent data obtained by labeled C-acetate PET studies in healthy humans. Our results indicate a close resemblance between theoretically predicted MVO2 data and actual measurements performed in humans and dogs. In addition, this study suggests neural modulation of the MVO2-ESV relationship by illustrating the effects of various adrenergic interventions.

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M3 - Paper

SP - 115

EP - 116

Y2 - 20 September 1995 through 23 September 1995

ER -

Kerkhof PLM, Weber MF, Vanoverschelde JLJ, Cheng CP. Neural modulation of myocardial oxygen consumption: experiments and model study based on the alternative starling curve description. 1995. Paper presented at Proceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2), Montreal, Can.

Neural modulation of myocardial oxygen consumption: experiments and model study based on the alternative starling curve description

Abstract

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