Neurological improvement of perineural and leptomeningeal spread of squamous cell carcinoma treated with intrathecal chemotherapy and systemic EGFR inhibition

Vincent Alexander van Vugt; Marlon Garzo Saria; Andres Javier; Navin Kesari; Tiffany Turpin; Santosh Kesari

doi:https://doi.org/10.2217/cns-2017-0010

Neurological improvement of perineural and leptomeningeal spread of squamous cell carcinoma treated with intrathecal chemotherapy and systemic EGFR inhibition

Vincent Alexander van Vugt, Marlon Garzo Saria, Andres Javier, Navin Kesari, Tiffany Turpin, Santosh Kesari

General Practice (VUmc)

Research output: Contribution to journal › Article › Academic › peer-review

5 Citations (Scopus)

Abstract

Squamous cell carcinoma (SCC) is a common cancer of the skin. Risk factors include fair skin, excessive sun and ultraviolet light exposure, and history of xeroderma pigmentosa. Perineural invasion (PNI), an uncommon manifestation of SCC, involves microscopic tumor cells invading various layers of the nerve sheath. It is associated with a poorer prognosis. Standard treatment for PNI includes radiation therapy. Here, we describe a case an older gentleman with a history of SCC with PNI successfully treated with erlotinib and intrathecal chemotherapy.

Original language	English
Pages (from-to)	269-274
Number of pages	6
Journal	CNS oncology
Volume	6
Issue number	4
DOIs	https://doi.org/10.2217/cns-2017-0010
Publication status	Published - Oct 2017

Keywords

Journal Article

Access to Document

https://doi.org/10.2217/cns-2017-0010

Cite this

@article{be5ee1b8c70349de8bd17aef1f8beb22,

title = "Neurological improvement of perineural and leptomeningeal spread of squamous cell carcinoma treated with intrathecal chemotherapy and systemic EGFR inhibition",

abstract = "Squamous cell carcinoma (SCC) is a common cancer of the skin. Risk factors include fair skin, excessive sun and ultraviolet light exposure, and history of xeroderma pigmentosa. Perineural invasion (PNI), an uncommon manifestation of SCC, involves microscopic tumor cells invading various layers of the nerve sheath. It is associated with a poorer prognosis. Standard treatment for PNI includes radiation therapy. Here, we describe a case an older gentleman with a history of SCC with PNI successfully treated with erlotinib and intrathecal chemotherapy.",

keywords = "Journal Article",

author = "{van Vugt}, {Vincent Alexander} and Saria, {Marlon Garzo} and Andres Javier and Navin Kesari and Tiffany Turpin and Santosh Kesari",

year = "2017",

month = oct,

doi = "https://doi.org/10.2217/cns-2017-0010",

language = "English",

volume = "6",

pages = "269--274",

journal = "CNS oncology",

issn = "2045-0907",

publisher = "Future Medicine Ltd.",

number = "4",

}

TY - JOUR

T1 - Neurological improvement of perineural and leptomeningeal spread of squamous cell carcinoma treated with intrathecal chemotherapy and systemic EGFR inhibition

AU - van Vugt, Vincent Alexander

AU - Saria, Marlon Garzo

AU - Javier, Andres

AU - Kesari, Navin

AU - Turpin, Tiffany

AU - Kesari, Santosh

PY - 2017/10

Y1 - 2017/10

N2 - Squamous cell carcinoma (SCC) is a common cancer of the skin. Risk factors include fair skin, excessive sun and ultraviolet light exposure, and history of xeroderma pigmentosa. Perineural invasion (PNI), an uncommon manifestation of SCC, involves microscopic tumor cells invading various layers of the nerve sheath. It is associated with a poorer prognosis. Standard treatment for PNI includes radiation therapy. Here, we describe a case an older gentleman with a history of SCC with PNI successfully treated with erlotinib and intrathecal chemotherapy.

AB - Squamous cell carcinoma (SCC) is a common cancer of the skin. Risk factors include fair skin, excessive sun and ultraviolet light exposure, and history of xeroderma pigmentosa. Perineural invasion (PNI), an uncommon manifestation of SCC, involves microscopic tumor cells invading various layers of the nerve sheath. It is associated with a poorer prognosis. Standard treatment for PNI includes radiation therapy. Here, we describe a case an older gentleman with a history of SCC with PNI successfully treated with erlotinib and intrathecal chemotherapy.

KW - Journal Article

U2 - https://doi.org/10.2217/cns-2017-0010

DO - https://doi.org/10.2217/cns-2017-0010

M3 - Article

C2 - 28984139

SN - 2045-0907

VL - 6

SP - 269

EP - 274

JO - CNS oncology

JF - CNS oncology

IS - 4

ER -