Neutrophil extracellular traps in patients with pulmonary tuberculosis

Anne Jan van der Meer; Sacha Zeerleder; Dana C. Blok; Liesbeth M. Kager; Ivar O. Lede; Wahid Rahman; Rumana Afroz; Aniruddha Ghose; Caroline E. Visser; Abu Shahed Md Zahed; Md Anwar Husain; Khan Mashrequl Alam; Pravat Chandra Barua; Mahtabuddin Hassan; Md Abu Tayab; Arjen M. Dondorp; Tom van der Poll

doi:https://doi.org/10.1186/s12931-017-0663-1

Neutrophil extracellular traps in patients with pulmonary tuberculosis

Anne Jan van der Meer, Sacha Zeerleder, Dana C. Blok, Liesbeth M. Kager, Ivar O. Lede, Wahid Rahman, Rumana Afroz, Aniruddha Ghose, Caroline E. Visser, Abu Shahed Md Zahed, Md Anwar Husain, Khan Mashrequl Alam, Pravat Chandra Barua, Mahtabuddin Hassan, Md Abu Tayab, Arjen M. Dondorp, Tom van der Poll

Research output: Contribution to journal › Comment/Letter to the editor › Academic

16 Citations (Scopus)

Abstract

Tuberculosis is a devastating infectious disease causing many deaths worldwide. Recent investigations have implicated neutrophil extracellular traps (NETs) in the host response to tuberculosis. The aim of the current study was to obtain evidence for NETs release in the circulation during human tuberculosis. For this we measured the plasma concentrations of nucleosomes in conjunction with neutrophil elastase, in 64 patients with active pulmonary tuberculosis and 32 healthy controls. Patients with active tuberculosis had elevated plasma levels of nucleosomes and elastase when compared with local healthy blood donors. Furthermore nucleosome and elastase levels showed a positive correlation. These findings provide the first evidence for the release of NETs in the circulation of patients with active pulmonary tuberculosis

Original language	English
Pages (from-to)	181
Journal	Respiratory Research
Volume	18
Issue number	1
DOIs	https://doi.org/10.1186/s12931-017-0663-1
Publication status	Published - 2017

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https://doi.org/10.1186/s12931-017-0663-1

Cite this

van der Meer, A. J., Zeerleder, S., Blok, D. C., Kager, L. M., Lede, I. O., Rahman, W., Afroz, R., Ghose, A., Visser, C. E., Zahed, A. S. M., Husain, M. A., Alam, K. M., Barua, P. C., Hassan, M., Tayab, M. A., Dondorp, A. M., & van der Poll, T. (2017). Neutrophil extracellular traps in patients with pulmonary tuberculosis. Respiratory Research, 18(1), 181. https://doi.org/10.1186/s12931-017-0663-1

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title = "Neutrophil extracellular traps in patients with pulmonary tuberculosis",

abstract = "Tuberculosis is a devastating infectious disease causing many deaths worldwide. Recent investigations have implicated neutrophil extracellular traps (NETs) in the host response to tuberculosis. The aim of the current study was to obtain evidence for NETs release in the circulation during human tuberculosis. For this we measured the plasma concentrations of nucleosomes in conjunction with neutrophil elastase, in 64 patients with active pulmonary tuberculosis and 32 healthy controls. Patients with active tuberculosis had elevated plasma levels of nucleosomes and elastase when compared with local healthy blood donors. Furthermore nucleosome and elastase levels showed a positive correlation. These findings provide the first evidence for the release of NETs in the circulation of patients with active pulmonary tuberculosis",

author = "{van der Meer}, {Anne Jan} and Sacha Zeerleder and Blok, {Dana C.} and Kager, {Liesbeth M.} and Lede, {Ivar O.} and Wahid Rahman and Rumana Afroz and Aniruddha Ghose and Visser, {Caroline E.} and Zahed, {Abu Shahed Md} and Husain, {Md Anwar} and Alam, {Khan Mashrequl} and Barua, {Pravat Chandra} and Mahtabuddin Hassan and Tayab, {Md Abu} and Dondorp, {Arjen M.} and {van der Poll}, Tom",

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van der Meer, AJ, Zeerleder, S, Blok, DC, Kager, LM, Lede, IO, Rahman, W, Afroz, R, Ghose, A, Visser, CE, Zahed, ASM, Husain, MA, Alam, KM, Barua, PC, Hassan, M, Tayab, MA, Dondorp, AM & van der Poll, T 2017, 'Neutrophil extracellular traps in patients with pulmonary tuberculosis', Respiratory Research, vol. 18, no. 1, pp. 181. https://doi.org/10.1186/s12931-017-0663-1

TY - JOUR

T1 - Neutrophil extracellular traps in patients with pulmonary tuberculosis

AU - van der Meer, Anne Jan

AU - Zeerleder, Sacha

AU - Blok, Dana C.

AU - Kager, Liesbeth M.

AU - Lede, Ivar O.

AU - Rahman, Wahid

AU - Afroz, Rumana

AU - Ghose, Aniruddha

AU - Visser, Caroline E.

AU - Zahed, Abu Shahed Md

AU - Husain, Md Anwar

AU - Alam, Khan Mashrequl

AU - Barua, Pravat Chandra

AU - Hassan, Mahtabuddin

AU - Tayab, Md Abu

AU - Dondorp, Arjen M.

AU - van der Poll, Tom

PY - 2017

Y1 - 2017

N2 - Tuberculosis is a devastating infectious disease causing many deaths worldwide. Recent investigations have implicated neutrophil extracellular traps (NETs) in the host response to tuberculosis. The aim of the current study was to obtain evidence for NETs release in the circulation during human tuberculosis. For this we measured the plasma concentrations of nucleosomes in conjunction with neutrophil elastase, in 64 patients with active pulmonary tuberculosis and 32 healthy controls. Patients with active tuberculosis had elevated plasma levels of nucleosomes and elastase when compared with local healthy blood donors. Furthermore nucleosome and elastase levels showed a positive correlation. These findings provide the first evidence for the release of NETs in the circulation of patients with active pulmonary tuberculosis

AB - Tuberculosis is a devastating infectious disease causing many deaths worldwide. Recent investigations have implicated neutrophil extracellular traps (NETs) in the host response to tuberculosis. The aim of the current study was to obtain evidence for NETs release in the circulation during human tuberculosis. For this we measured the plasma concentrations of nucleosomes in conjunction with neutrophil elastase, in 64 patients with active pulmonary tuberculosis and 32 healthy controls. Patients with active tuberculosis had elevated plasma levels of nucleosomes and elastase when compared with local healthy blood donors. Furthermore nucleosome and elastase levels showed a positive correlation. These findings provide the first evidence for the release of NETs in the circulation of patients with active pulmonary tuberculosis

U2 - https://doi.org/10.1186/s12931-017-0663-1

DO - https://doi.org/10.1186/s12931-017-0663-1

M3 - Comment/Letter to the editor

C2 - 29084563

SN - 1465-9921

VL - 18

SP - 181

JO - Respiratory Research

JF - Respiratory Research

IS - 1

ER -