New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

Alcohol Genome-Wide Consortium; Juha Auvinen; Chunyu Liu; Minna Männikkö; Lorenz Risch; Jerome I. Rotter; Harold Snieder; Juha Veijola; Alexandra I. Blakemore; Michael Boehnke; Harry Campbell; David Conen; Johan G. Eriksson; Hans J. Grabe; Xiuqing Guo; Pim van der Harst; Catharina A. Hartman; Caroline Hayward; Andrew C. Heath; Marjo-Riitta Jarvelin; Mika Kähönen; Sharon L. R. Kardia; Michael Kühne; Johanna Kuusisto; Markku Laakso; Jari Lahti; Terho Lehtimäki; Andrew M. McIntosh; Karen L. Mohlke; Alanna C. Morrison; Nicholas G. Martin; Albertine J. Oldehinkel; Bruce M. Psaty; Olli T. Raitakari; Igor Rudan; Nilesh J. Samani; Laura J. Scott; Tim D. Spector; Niek Verweij; David R. Weir; James F. Wilson; Daniel Levy; Ioanna Tzoulaki; Jimmy D. Bell; Paul M. Matthews; Adrian Rothenfluh; Sylvane Desrivières; Gunter Schumann; Paul Elliott

doi:https://doi.org/10.1038/s41562-019-0653-z

New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

Alcohol Genome-Wide Consortium, Juha Auvinen, Chunyu Liu, Minna Männikkö, Lorenz Risch, Jerome I. Rotter, Harold Snieder, Juha Veijola, Alexandra I. Blakemore, Michael Boehnke, Harry Campbell, David Conen, Johan G. Eriksson, Hans J. Grabe, Xiuqing Guo, Pim van der Harst, Catharina A. Hartman, Caroline Hayward, Andrew C. Heath, Marjo-Riitta JarvelinMika Kähönen, Sharon L. R. Kardia, Michael Kühne, Johanna Kuusisto, Markku Laakso, Jari Lahti, Terho Lehtimäki, Andrew M. McIntosh, Karen L. Mohlke, Alanna C. Morrison, Nicholas G. Martin, Albertine J. Oldehinkel, Bruce M. Psaty, Olli T. Raitakari, Igor Rudan, Nilesh J. Samani, Laura J. Scott, Tim D. Spector, Niek Verweij, David R. Weir, James F. Wilson, Daniel Levy, Ioanna Tzoulaki, Jimmy D. Bell, Paul M. Matthews, Adrian Rothenfluh, Sylvane Desrivières, Gunter Schumann, Paul Elliott

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d⁻¹) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 new common loci and investigated their potential functional importance using magnetic resonance imaging data and gene expression studies. We identify genetic pathways associated with alcohol consumption and suggest genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia.

Original language	English
Pages (from-to)	950-961
Number of pages	12
Journal	Nature Human Behaviour
Volume	3
Issue number	9
DOIs	https://doi.org/10.1038/s41562-019-0653-z
Publication status	Published - 1 Sept 2019

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Alcohol Genome-Wide Consortium, Auvinen, J., Liu, C., Männikkö, M., Risch, L., Rotter, J. I., Snieder, H., Veijola, J., Blakemore, A. I., Boehnke, M., Campbell, H., Conen, D., Eriksson, J. G., Grabe, H. J., Guo, X., van der Harst, P., Hartman, C. A., Hayward, C., Heath, A. C., ... Elliott, P. (2019). New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders. Nature Human Behaviour, 3(9), 950-961. https://doi.org/10.1038/s41562-019-0653-z

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title = "New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders",

abstract = "Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d−1) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 new common loci and investigated their potential functional importance using magnetic resonance imaging data and gene expression studies. We identify genetic pathways associated with alcohol consumption and suggest genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia.",

author = "Evangelos Evangelou and {Alcohol Genome-Wide Consortium} and He Gao and Congying Chu and Georgios Ntritsos and Paul Blakeley and Butts, {Andrew R.} and Raha Pazoki and Hideaki Suzuki and Fotios Koskeridis and Yiorkas, {Andrianos M.} and Ibrahim Karaman and Joshua Elliott and Qiang Luo and Stefanie Aeschbacher and Bartz, {Traci M.} and Baumeister, {Sebastian E.} and Braund, {Peter S.} and Brown, {Michael R.} and Brody, {Jennifer A.} and Clarke, {Toni Kim} and Niki Dimou and Faul, {Jessica D.} and Georg Homuth and Jackson, {Anne U.} and Kentistou, {Katherine A.} and Joshi, {Peter K.} and Lemaitre, {Rozenn N.} and Lind, {Penelope A.} and Lyytik{\"a}inen, {Leo Pekka} and Massimo Mangino and Yuri Milaneschi and Nelson, {Christopher P.} and Nolte, {Ilja M.} and Per{\"a}l{\"a}, {Mia Maria} and Ozren Polasek and David Porteous and Ratliff, {Scott M.} and Smith, {Jennifer A.} and Alena Stan{\v c}{\'a}kov{\'a} and Alexander Teumer and Samuli Tuominen and S{\'e}bastien Th{\'e}riault and Jagadish Vangipurapu and Whitfield, {John B.} and Alexis Wood and Jie Yao and Bing Yu and Wei Zhao and Arking, {Dan E.} and BWJH Penninx and Juha Auvinen and Chunyu Liu and Minna M{\"a}nnikk{\"o} and Lorenz Risch and Rotter, {Jerome I.} and Harold Snieder and Juha Veijola and Blakemore, {Alexandra I.} and Michael Boehnke and Harry Campbell and David Conen and Eriksson, {Johan G.} and Grabe, {Hans J.} and Xiuqing Guo and {van der Harst}, Pim and Hartman, {Catharina A.} and Caroline Hayward and Heath, {Andrew C.} and Marjo-Riitta Jarvelin and Mika K{\"a}h{\"o}nen and Kardia, {Sharon L. R.} and Michael K{\"u}hne and Johanna Kuusisto and Markku Laakso and Jari Lahti and Terho Lehtim{\"a}ki and McIntosh, {Andrew M.} and Mohlke, {Karen L.} and Morrison, {Alanna C.} and Martin, {Nicholas G.} and Oldehinkel, {Albertine J.} and Psaty, {Bruce M.} and Raitakari, {Olli T.} and Igor Rudan and Samani, {Nilesh J.} and Scott, {Laura J.} and Spector, {Tim D.} and Niek Verweij and Weir, {David R.} and Wilson, {James F.} and Daniel Levy and Ioanna Tzoulaki and Bell, {Jimmy D.} and Matthews, {Paul M.} and Adrian Rothenfluh and Sylvane Desrivi{\`e}res and Gunter Schumann and Paul Elliott",

year = "2019",

month = sep,

day = "1",

doi = "https://doi.org/10.1038/s41562-019-0653-z",

language = "English",

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pages = "950--961",

journal = "Nature Human Behaviour",

issn = "2397-3374",

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Alcohol Genome-Wide Consortium, Auvinen, J, Liu, C, Männikkö, M, Risch, L, Rotter, JI, Snieder, H, Veijola, J, Blakemore, AI, Boehnke, M, Campbell, H, Conen, D, Eriksson, JG, Grabe, HJ, Guo, X, van der Harst, P, Hartman, CA, Hayward, C, Heath, AC, Jarvelin, M-R, Kähönen, M, Kardia, SLR, Kühne, M, Kuusisto, J, Laakso, M, Lahti, J, Lehtimäki, T, McIntosh, AM, Mohlke, KL, Morrison, AC, Martin, NG, Oldehinkel, AJ, Psaty, BM, Raitakari, OT, Rudan, I, Samani, NJ, Scott, LJ, Spector, TD, Verweij, N, Weir, DR, Wilson, JF, Levy, D, Tzoulaki, I, Bell, JD, Matthews, PM, Rothenfluh, A, Desrivières, S, Schumann, G & Elliott, P 2019, 'New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders', Nature Human Behaviour, vol. 3, no. 9, pp. 950-961. https://doi.org/10.1038/s41562-019-0653-z

TY - JOUR

T1 - New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

AU - Evangelou, Evangelos

AU - Alcohol Genome-Wide Consortium

AU - Gao, He

AU - Chu, Congying

AU - Ntritsos, Georgios

AU - Blakeley, Paul

AU - Butts, Andrew R.

AU - Pazoki, Raha

AU - Suzuki, Hideaki

AU - Koskeridis, Fotios

AU - Yiorkas, Andrianos M.

AU - Karaman, Ibrahim

AU - Elliott, Joshua

AU - Luo, Qiang

AU - Aeschbacher, Stefanie

AU - Bartz, Traci M.

AU - Baumeister, Sebastian E.

AU - Braund, Peter S.

AU - Brown, Michael R.

AU - Brody, Jennifer A.

AU - Clarke, Toni Kim

AU - Dimou, Niki

AU - Faul, Jessica D.

AU - Homuth, Georg

AU - Jackson, Anne U.

AU - Kentistou, Katherine A.

AU - Joshi, Peter K.

AU - Lemaitre, Rozenn N.

AU - Lind, Penelope A.

AU - Lyytikäinen, Leo Pekka

AU - Mangino, Massimo

AU - Milaneschi, Yuri

AU - Nelson, Christopher P.

AU - Nolte, Ilja M.

AU - Perälä, Mia Maria

AU - Polasek, Ozren

AU - Porteous, David

AU - Ratliff, Scott M.

AU - Smith, Jennifer A.

AU - Stančáková, Alena

AU - Teumer, Alexander

AU - Tuominen, Samuli

AU - Thériault, Sébastien

AU - Vangipurapu, Jagadish

AU - Whitfield, John B.

AU - Wood, Alexis

AU - Yao, Jie

AU - Yu, Bing

AU - Zhao, Wei

AU - Arking, Dan E.

AU - Penninx, BWJH

AU - Auvinen, Juha

AU - Liu, Chunyu

AU - Männikkö, Minna

AU - Risch, Lorenz

AU - Rotter, Jerome I.

AU - Snieder, Harold

AU - Veijola, Juha

AU - Blakemore, Alexandra I.

AU - Boehnke, Michael

AU - Campbell, Harry

AU - Conen, David

AU - Eriksson, Johan G.

AU - Grabe, Hans J.

AU - Guo, Xiuqing

AU - van der Harst, Pim

AU - Hartman, Catharina A.

AU - Hayward, Caroline

AU - Heath, Andrew C.

AU - Jarvelin, Marjo-Riitta

AU - Kähönen, Mika

AU - Kardia, Sharon L. R.

AU - Kühne, Michael

AU - Kuusisto, Johanna

AU - Laakso, Markku

AU - Lahti, Jari

AU - Lehtimäki, Terho

AU - McIntosh, Andrew M.

AU - Mohlke, Karen L.

AU - Morrison, Alanna C.

AU - Martin, Nicholas G.

AU - Oldehinkel, Albertine J.

AU - Psaty, Bruce M.

AU - Raitakari, Olli T.

AU - Rudan, Igor

AU - Samani, Nilesh J.

AU - Scott, Laura J.

AU - Spector, Tim D.

AU - Verweij, Niek

AU - Weir, David R.

AU - Wilson, James F.

AU - Levy, Daniel

AU - Tzoulaki, Ioanna

AU - Bell, Jimmy D.

AU - Matthews, Paul M.

AU - Rothenfluh, Adrian

AU - Desrivières, Sylvane

AU - Schumann, Gunter

AU - Elliott, Paul

PY - 2019/9/1

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AB - Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d−1) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 new common loci and investigated their potential functional importance using magnetic resonance imaging data and gene expression studies. We identify genetic pathways associated with alcohol consumption and suggest genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia.

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SN - 2397-3374

VL - 3

SP - 950

EP - 961

JO - Nature Human Behaviour

JF - Nature Human Behaviour

IS - 9

ER -

New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

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