New aspects of signal transduction in the Xenopus laevis melanotrope cell

E. W. Roubos, W. J.J.M. Scheenen, P. M.J.M. Cruijsen, L. N. Cornelisse, H. J. Leenders, B. G. Jenks

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)


Light and temperature stimuli act via various brain centers and neurochemical messengers on the pituitary melanotrope cells of Xenopus laevis to control distinct subcellular activities such as the biosynthesis, processing, and release of α-melanophore-stimulating hormone (αMSH). The melanotrope signal transduction involves the action of a large repertoire of neurotransmitter and neuropeptide receptors and the second messengers cAMP and Ca2+. Here we briefly review this signaling mechanism and then present new data on two aspects of this process, viz. the presence of a stimulatory β-adrenergic receptor acting via cAMP and the egress of cAMP from the melanotrope upon a change of αMSH release activity.

Original languageEnglish
Pages (from-to)255-260
Number of pages6
JournalGeneral and comparative endocrinology
Issue number3
Publication statusPublished - 1 Jan 2002
Externally publishedYes

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