TY - JOUR
T1 - New clues regarding the mysterious mechanism of activated thrombin-activatable fibrinolysis inhibitor self-destruction
AU - Plug, T.
AU - Meijers, J. C. M.
PY - 2015
Y1 - 2015
N2 - A new TAFI deletion mutant, constructed by Zhou et al. [1], provides us with new clues on the mysterious mechanism of spontaneous TAFIa self-destruction. Thrombin-Activatable Fibrinolysis Inhibitor (TAFI), also known as procarboxypeptidase U, procarboxypeptidase R and procarboxypeptidase B2, is encoded by the CPB2 gene [2]. TAFI is synthesized in the liver and circulates in plasma as a proenzyme. During coagulation, TAFI is activated by a single proteolytic cleavage at Arg92 that releases the activation peptide from the catalytic domain [3]. This article is protected by copyright. All rights reserved
AB - A new TAFI deletion mutant, constructed by Zhou et al. [1], provides us with new clues on the mysterious mechanism of spontaneous TAFIa self-destruction. Thrombin-Activatable Fibrinolysis Inhibitor (TAFI), also known as procarboxypeptidase U, procarboxypeptidase R and procarboxypeptidase B2, is encoded by the CPB2 gene [2]. TAFI is synthesized in the liver and circulates in plasma as a proenzyme. During coagulation, TAFI is activated by a single proteolytic cleavage at Arg92 that releases the activation peptide from the catalytic domain [3]. This article is protected by copyright. All rights reserved
U2 - https://doi.org/10.1111/jth.12900
DO - https://doi.org/10.1111/jth.12900
M3 - Editorial
C2 - 25777152
SN - 1538-7933
VL - 13
SP - 1081
EP - 1083
JO - Journal of thrombosis and haemostasis
JF - Journal of thrombosis and haemostasis
IS - 6
ER -