TY - JOUR
T1 - No genetic association between attention-deficit/hyperactivity disorder (ADHD) and Parkinson’s disease in nine ADHD candidate SNPs
AU - International Parkinson Disease Genomics Consortium members
AU - Geissler, Julia M.
AU - Nalls, Mike
AU - Plagnol, Vincent
AU - Hernandez, Dena G.
AU - Sharma, Manu
AU - Sheerin, Una Marie
AU - Saad, Mohamad
AU - Simón-Sánchez, Javier
AU - Schulte, Claudia
AU - Lesage, Suzanne
AU - Sveinbjörnsdóttir, Sigurlaug
AU - Arepalli, Sampath
AU - Barker, Roger
AU - Ben-Shlomo, Yoav
AU - Berendse, Henk W.
AU - Berg, Daniela
AU - Bhatia, Kailash
AU - deBie, Rob M.A.
AU - Biffi, Alessandro
AU - Bloem, Bas
AU - Bochdanovits, Zoltan
AU - Bonin, Michael
AU - Bras, Jose M.
AU - Brockmann, Kathrin
AU - Brooks, Janet
AU - Burn, David J.
AU - Charlesworth, Gavin
AU - Chen, Honglei
AU - Chinnery, Patrick F.
AU - Chong, Sean
AU - Clarke, Carl E.
AU - Cookson, Mark R.
AU - Cooper, J. Mark
AU - Corvol, Jean Christophe
AU - Counsell, Carl
AU - Damier, Philippe
AU - Dartigues, Jean François
AU - Deloukas, Panos
AU - Deuschl, Günther
AU - Dexter, David T.
AU - vanDijk, Karin D.
AU - Dillman, Allissa
AU - Durif, Frank
AU - Dürr, Alexandra
AU - Edkins, Sarah
AU - Evans, Jonathan R.
AU - Foltynie, Thomas
AU - Gao, Jianjun
AU - Gardner, Michelle
AU - Heutink, Peter
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Attention-deficit/hyperactivity disorder (ADHD) and Parkinson’s disease (PD) involve pathological changes in brain structures such as the basal ganglia, which are essential for the control of motor and cognitive behavior and impulsivity. The cause of ADHD and PD remains unknown, but there is increasing evidence that both seem to result from a complicated interplay of genetic and environmental factors affecting numerous cellular processes and brain regions. To explore the possibility of common genetic pathways within the respective pathophysiologies, nine ADHD candidate single nucleotide polymorphisms (SNPs) in seven genes were tested for association with PD in 5333 cases and 12,019 healthy controls: one variant, respectively, in the genes coding for synaptosomal-associated protein 25k (SNAP25), the dopamine (DA) transporter (SLC6A3; DAT1), DA receptor D4 (DRD4), serotonin receptor 1B (HTR1B), tryptophan hydroxylase 2 (TPH2), the norepinephrine transporter SLC6A2 and three SNPs in cadherin 13 (CDH13). Information was extracted from a recent meta-analysis of five genome-wide association studies, in which 7,689,524 SNPs in European samples were successfully imputed. No significant association was observed after correction for multiple testing. Therefore, it is reasonable to conclude that candidate variants implicated in the pathogenesis of ADHD do not play a substantial role in PD.
AB - Attention-deficit/hyperactivity disorder (ADHD) and Parkinson’s disease (PD) involve pathological changes in brain structures such as the basal ganglia, which are essential for the control of motor and cognitive behavior and impulsivity. The cause of ADHD and PD remains unknown, but there is increasing evidence that both seem to result from a complicated interplay of genetic and environmental factors affecting numerous cellular processes and brain regions. To explore the possibility of common genetic pathways within the respective pathophysiologies, nine ADHD candidate single nucleotide polymorphisms (SNPs) in seven genes were tested for association with PD in 5333 cases and 12,019 healthy controls: one variant, respectively, in the genes coding for synaptosomal-associated protein 25k (SNAP25), the dopamine (DA) transporter (SLC6A3; DAT1), DA receptor D4 (DRD4), serotonin receptor 1B (HTR1B), tryptophan hydroxylase 2 (TPH2), the norepinephrine transporter SLC6A2 and three SNPs in cadherin 13 (CDH13). Information was extracted from a recent meta-analysis of five genome-wide association studies, in which 7,689,524 SNPs in European samples were successfully imputed. No significant association was observed after correction for multiple testing. Therefore, it is reasonable to conclude that candidate variants implicated in the pathogenesis of ADHD do not play a substantial role in PD.
KW - ADHD
KW - CDH13
KW - Dopamine transporter
KW - GWAS
KW - Parkinson’s disease
KW - SNPs
UR - http://www.scopus.com/inward/record.url?scp=85011887445&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/s12402-017-0219-8
DO - https://doi.org/10.1007/s12402-017-0219-8
M3 - Article
SN - 1866-6116
VL - 9
SP - 121
EP - 127
JO - ADHD Attention Deficit and Hyperactivity Disorders
JF - ADHD Attention Deficit and Hyperactivity Disorders
IS - 2
ER -